Human N-Cadherin Alexa Fluor 488 Affinity Purified PAb (100 TESTS)【科瑞奥博】

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Human N-Cadherin Alexa Fluor 488 Affinity Purified PAb (100 TESTS)

货号： FAB6426G 基本售价： 4521.0 元规格： 100 Tests

产品信息

概述
货号	FAB6426G
别名	cadherin 2, N-cadherin (neuronal); cadherin 2, type 1, N-cadherin (neuronal); Cadherin-2; CD325 antigen; CD325; CDH2; CDHNcalcium-dependent adhesion protein, neuronal; CDw325; N-cadherin; NCADN-cadherin 1; Neural cadherin; neural-cadherin
全称	Neural Cadherin
反应种属	Human
应用	Flow Cytometry(5 µL/10⁶cells)
目标/特异性	Detects human, mouse, and rat N‑Cadherin in Western blots. In direct ELISA, less than 1% cross-reactivity with recombinant human (rh) E-Cadherin, rhR-Cadherin, and rhCadherin-13 is observed.
使用方法	Flow Cytometry: 5 µL/10⁶cells
来源	The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
产品组分

性能
供应商	R&D Systems
Entrez Gene IDs	1000 (Human); 12558 (Mouse); 83501 (Rat)
纯化方式	Antigen Affinity-purified
免疫原	Mouse myeloma cell line NS0-derived recombinant human N‑Cadherin Asp160-Ala724 Accession # P19022
生物活性	Human
标记	Alexa Fluor 488
背景	N-Cadherin (Neural Cadherin), also known as CD325 and Cadherin-2, is a 130-135 kDa member of the "classical" (or type I) cadherin subfamily, cadherin superfamily of proteins. It is expressed on multiple cell types, including neurons, fibroblasts, Schwann cells, endothelial cells and hepatic stellate cells. N-Cadherin mediates homotypic binding, either in cis (same cell) or trans (adjacent cell). proN-Cadherin is expressed as an 881 amino acid (aa) type I transmembrane glycoprotein. It may be initially inserted into the ER, where the 15-20 kDa prodomain (aa 26-159) is cleaved by proprotein convertase, and the mature molecule (aa 160-906) is transported to the surface. Mature N-Cadherin contains a 565 aa extracellular region (aa 160-724) that possesses five cadherin domains (aa 160-714), and a 161 aa cytoplasmic tail that undergoes phosphorylation at Tyr785. There is one splice variant that contains a 10 aa substitution for aa 839-906. Over aa 160-724, human N Cadherin shares 98% aa sequence identity with mouse N-Cadherin.
运输条件	Blue Ice
存放说明	4℃
参考文献	Adhesion Molecules Cadherin Superfamily Early Mesodermal Lineage Markers Endothelial Cell Markers and Adhesion Molecules in Angiogenesis Human CD Marker Products ICC / IHC Images: N-Cadherin Mesenchymal Cells and EMT Mesenchymal Stem Cell Markers Mini-review: Adhesion Molecules II Neural Stem Cell Markers Regulation of VE-Cadherin and VEGF R2 by VEGF Synaptic Adhesion Molecules Synaptic Proteins

参考图片

Detection of N‑Cadherin in HeLa Human Cell Line by Flow Cytometry. HeLa human cervical epithelial carcinoma cell line was stained with Sheep Anti-Human N‑Cadherin Alexa Fluor® 488‑conjugated Antigen Affinity-purified Polyclonal Antibody (Catalog # FAB6426G, filled histogram) or isotype control antibody (Catalog # IC016G, open histogram). View our protocol for Staining Membrane-associated Proteins.