Human TLR5 Alexa Fluor 488 MAb (Clone 624915) (100 TESTS)【科瑞奥博】

产品中心

当前位置：首页>产品中心

Human TLR5 Alexa Fluor 488 MAb (Clone 624915) (100 TESTS)

货号： FAB6704G 基本售价： 4521.0 元规格： 100 Tests

产品信息

概述
货号	FAB6704G
别名	MGC126430; MGC126431; SLEB1FLJ10052; TIL-3; TIL3Toll/interleukin-1 receptor-like protein 3; toll-like receptor 5
全称	Toll-like Receptor 5
反应种属	Human
应用	Flow Cytometry(5 µL/10⁶cells)
目标/特异性	Detects human TLR5 in direct ELISAs and Western blots. In Western blots, less than 5% cross-reactivity withrecombinant human (rh) TLR1, 2, 3, 4, 7, 8, recombinant mouse TLR5, 6, orrhTIRAP is observed.
使用方法	Flow Cytometry: 5 µL/10⁶cells
来源	The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
产品组分

性能
供应商	R&D Systems
Entrez Gene IDs	7100 (Human); 53791 (Mouse); 289337 (Rat)
纯化方式	Protein A or G purified from hybridoma culture supernatant
免疫原	E. coli-derived recombinant human TLR5 Ile21-Phe115 Accession # O60602
生物活性	Human
标记	Alexa Fluor 488
背景	TLR5 is an ~100 kDa type I transmembrane glycoprotein of the Toll-like receptor family. It is expressed on mucosal epithelia in the gastrointestinal tract, airways, and other areas of potential bacterial contact and recognizes bacterial flagellin. Expression is also reported on monocytes, immature dendritic cells, and CD4⁺ T lymphocytes. The region of human TLR5 used as an immunogen includes the first 2 of 16 leucine-rich repeats and shares 72% amino acid identity with mouse and rat TLR5. This region is outside of the flagellin binding region. Flagellin engagement induces dimerization and intracellular signaling via MyD88.
运输条件	Blue Ice
存放说明	4℃
参考文献	BIObrief: Pattern Recognition Receptors & the Innate Immune Response ICC / IHC Images: TLR5 IL-1 Family Innate Immunity and the Toll-like Receptor Family Interactive Pathway: Inflammasome Activation Pathways Interactive Pathway: Toll-Like receptor Signaling Pathways Mini-review: The Toll-like Receptor Family Neuroinflammation NFkB Pathway NOD-like Receptors and the Inflammasome Parturition & Surfactant Protein A Pattern Recognition Receptors TLR4: Contributing to Metabolic Syndrome in Multiple Tissues Toll-Like Receptors

参考图片

Detection of TLR5 in Human Blood Monocytes by Flow Cytometry. Human peripheral blood monocytes were stained with Mouse Anti-Human TLR5 Alexa Fluor® 488‑conjugated Monoclonal Antibody (Catalog # FAB6704G, filled histogram) or isotype control antibody (Catalog # IC002G, open histogram). View our protocol for Staining Membrane-associated Proteins.