Human Integrin alpha 2b/CD41 Allophycocyanin MAb (Cl 745201) (100 TESTS)
货号：
FAB7616A 基本售价：
4521.0 元 规格：
100 Tests
产品信息
概述| 货号 | FAB7616A |
| 别名 | CD41 antigen; CD41; CD41BHPA3; GP2B; GP2Bintegrin alpha-IIb; GPalpha IIb; GPIIb; GTA; HPA3; integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigenCD41); integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigenCD41B); ITGA2b; ITGAB; platelet fibrinogen receptor, alpha subunit; Platelet membrane glycoprotein IIb; platelet-specific antigen BAK |
| 反应种属 | Human |
| 应用 | Flow Cytometry |
| 目标/特异性 | Detects human Integrin alpha 2b/CD41 in direct ELISAs.In direct ELISAs, no cross-reactivitywith recombinant human Integrin alpha 5, alpha 8, alpha V, beta 3, beta 5, beta 6, recombinant mouse Integrin beta 2b or beta 3 is observed. |
| 使用方法 | Flow Cytometry: 10 µL/106cells
|
| 来源 | The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below. |
| 产品组分 | |
性能| 供应商 | R&D Systems |
| Entrez Gene IDs | 3674 (Human); 16399 (Mouse); 29350 (Rat) |
| 纯化方式 | Protein A or G purified from hybridoma culture supernatant |
| 免疫原 | heterodimer of human Integrin alpha 2B (Leu32-Arg993; R887L) Accession P08514 + human Integrin beta 3 (Gly27-Asp718) Accession P05106
|
| 生物活性 | Human |
| 标记 | Allophycocyanin |
| 背景 | Integrin alpha 2b (ITGA2b), also known as CD41 and GPIIb, is a transmembrane glycoprotein that is expressed by megakaryocytes and platelets. It is cleaved into two disulfide-linked chains (114 kDa and 22 kDa) during transit through the Golgi. Integrin alpha 2b associates with Integrin beta 3 to form complexes that interact with Fibrinogen, von Willebrand factor, Fibronectin, and Vitronectin. Integrin alpha 2b is required for platelet aggregation, and defects lead to disorders of coagulation. Within the extracellular domain, human Integrin alpha 2b shares 80% and 78% amino acid sequence identity with mouse and rat Integrin alpha 2b, respectively. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 参考文献 | - Actin Stress Fibers and Focal Adhesions During EMT
- Adhesion Molecules
- HGF/SF Activation of Integrins
- Human CD Marker Products
- Integrin Ligands at a Glance (J. Cell. Sci.)
- Integrin Subunit Interactions
- Integrins and Associated Molecules
- Megakaryocytes
- Myeloid Lineage Markers
- Platelets
|
参考图片Detection of Integrin alpha 2b/CD41 in Human Blood Platelets by Flow Cytometry. Human peripheral blood platelets were stained with FITC-conjugated Anti-Human Integrin alpha 2b/CD41 Antibody (Clone P2) and either (A) Mouse Anti-Human Integrin alpha 2b/CD41 APC‑conjugated Monoclonal Antibody (Catalog # FAB7616A) or (B) Mouse IgG 1 Allophycocyanin Isotype Control (Catalog # IC002A). FAB7616A stains the same population as Clone P2. View our protocol for Staining Membrane-associated Proteins. |
