Human TM4SF1 Phycoerythrin MAb (Clone 877621) (100 TESTS)【科瑞奥博】

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Human TM4SF1 Phycoerythrin MAb (Clone 877621) (100 TESTS)

货号： FAB8164P 基本售价： 4382.2 元规格： 100 Tests

产品信息

概述
货号	FAB8164P
别名	L6; M3s1; M3S1Tumor-associated antigen L6; Membrane component chromosome 3 surface marker 1; membrane component, chromosome 3, surface marker 1; TAAL6; TAAL6H-L6; transmembrane 4 L six family member 1; transmembrane 4 L6 family member 1; transmembrane 4 superfamily member 1
全称	Transmembrane 4 L Six Family Member 1
反应种属	Human
应用	Flow Cytometry(10 µL/10⁶cells)
目标/特异性	Detects human TM4SF1/L6 in ELISA. Stains human TM4SF1/L6 transfected cells but not irrelevant transfectants.
使用方法	Flow Cytometry: 10 µL/10⁶cells
来源	The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
产品组分

性能

供应商

R&D Systems

Entrez Gene IDs

4071 (Human); 17112 (Mouse)

纯化方式

Protein A or G purified from hybridoma culture supernatant

免疫原

NS0 mouse myeloma cell line transfected with human TM4SF1/L6
Met1-Cys202
Accession # P30408

生物活性

Human

标记

Phycoerythrin

背景

TM4SF1 (Transmembrane 4 L6 family Member 1; also L6 and M3s1) is a 23-28 kDa member of the L6 tetraspanin family of molecules. It is expressed by fibroblasts, endothelial cells and a variety of tumor cells. TM4SF1 is embedded in both the plasma membrane and the membrane of late endocytic organelles. Here, it appears to be ubiquitinated, and to regulate endocytosis, an action that impacts effective cell migration. TM4SF1 is reported to interact with alpha 5 and beta 1 integrins, and this may impact cell motility. It also suppresses the expression of CD63 and CD82, two molecules that impede cell mobility. Human TM4SF1 is a 202 amino acid (aa) 4‑transmembrane (TM) glycoprotein. It contains a short N-terminal cytoplasmic region (aa 1-9), followed by four TM regions and another C-terminal cytoplasmic region (aa 183-202). Human TM4SF1 shares 78% and 80% aa sequence identity with mouse and rat TM4SF1, respectively.

运输条件

Blue Ice

存放说明

4℃

参考文献

Cancer Biomarkers
ICC / IHC Images: TM4SF1/L6

参考图片

Detection of TM4SF1/L6 in A549 Human Cell Line by Flow Cytometry. A549 human lung carcinoma cell line was stained with Mouse Anti-Human TM4SF1/L6 PE‑conjugated Monoclonal Antibody (Catalog # FAB8164P, filled histogram) or isotype control antibody (Catalog # IC002P, open histogram). View our protocol for Staining Membrane-associated Proteins.

Detection of TM4SF1/L6 in HEK293 Human Cell Line Transfected with Human TM4SF1/L6 and eGFP by Flow Cytometry. HEK293 human embryonic kidney cell line transfected with human TM4SF1/L6 and eGFP was stained with either (A) Mouse Anti-Human TM4SF1/L6 PE‑conjugated Monoclonal Antibody (Catalog # FAB8164P) or (B) Mouse IgG₁ Phycoerythrin Isotype Control (Catalog # IC002P). View our protocol for Staining Membrane-associated Proteins.