Human Integrin beta 7 Phycoerythrin MAb (Clone 473207) (100 TESTS)【科瑞奥博】

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Human Integrin beta 7 Phycoerythrin MAb (Clone 473207) (100 TESTS)

货号： FAB4669P 基本售价： 4382.2 元规格： 100 Tests

产品信息

概述
货号	FAB4669P
别名	Gut homing receptor beta subunit; integrin beta 7 subunit; integrin beta-7; integrin, beta 7; ITGB7
反应种属	Human
应用	Flow Cytometry(10 µL/10⁶cells)
目标/特异性	Detects human Integrin beta 7 in direct ELISAs and Western blots. In Western blots, no cross-reactivity with recombinant human Integrin beta 1, beta 2, beta 3, beta 4, beta 5, beta 6, beta 8, recombinant mouse Integrin beta 4, or beta 7 is observed.
使用方法	Flow Cytometry: 10 µL/10⁶cells
来源	The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
产品组分

性能
供应商	R&D Systems
Entrez Gene IDs	3695 (Human); 16421 (Mouse); 25713 (Rat)
纯化方式	Protein A or G purified from hybridoma culture supernatant
免疫原	Chinese hamster ovary cell line CHO-derived recombinant human Integrin beta 7 long isoform Glu20-His723 Accession # P26010
生物活性	Human
标记	Phycoerythrin
背景	Human Integrin beta 7, also known as Integrin beta P and M290 IEL Ag, is a 120 kDa member of the Integrin beta chain family of molecules. It is a type I transmembrane glycoprotein that contains a 704 amino acid (aa) extracellular domain (ECD) (aa 20‑723) and a 52 aa cytoplasmic tail. The ECD contains one von Willebrand factor A domain (aa 150‑389) and four cysteine‑rich EGF‑like repeats. One splice variant exists that shows a deletion of aa 501‑648. Integrin beta 7 forms a nondisulfide linked heterodimer with alpha 4 and alpha E integrins. alpha 4 beta 7 binds fibronectin, VCAM-1 and MADCAM1, while alpha E beta 7 binds E-cadherin. The ECD of human beta 7 is 87% aa identical to the ECD of mouse beta 7.
运输条件	Blue Ice
存放说明	4℃
参考文献	Acute Lymphoblastic Leukemia Adhesion Molecules Adhesive Interactions in Allergy and Asthma HGF/SF Activation of Integrins Integrin Ligands at a Glance (J. Cell. Sci.) Integrin Subunit Interactions Integrins and Associated Molecules

参考图片

Detection of Integrin beta 7 in Human Lymphocytes by Flow Cytometry. Human peripheral blood lymphocytes were stained with Mouse Anti-Human Integrin beta 7 PE‑conjugated Monoclonal Antibody (Catalog # FAB4669P, filled histogram) or isotype control antibody (Catalog # IC002P, open histogram). View our protocol for Staining Membrane-associated Proteins.