| 货号 | FAB4614P |
| 别名 | calcitonin receptor; CALCR; CRT; CTR; CT-R; CTR1 | 全称 | Calcitonin Receptor |
| 反应种属 | Human |
| 应用 | Flow Cytometry(10 µL/106cells) |
| 目标/特异性 | Detects human Calcitonin R. Stains human Calcitonin R transfectants but not irrelevant transfectants. |
| 使用方法 | Flow Cytometry: 10 µL/106cells |
| 来源 | The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below. |
| 产品组分 |
| 供应商 | R&D Systems |
| Entrez Gene IDs | 799 (Human); 12311 (Mouse); 116506 (Rat) |
| 纯化方式 | Protein A or G purified from hybridoma culture supernatant |
| 免疫原 | HEK293 human embryonic kidney cell line transfected with human Calcitonin R Ala25-Ala474 Accession # NP_001733 |
| 生物活性 | Human |
| 标记 | Phycoerythrin |
| 背景 | Calcitonin Receptor (CALCR) is a glycosylated 55-67 kDa seven-transmembrane G protein-coupled receptor that belongs to the GPCR2 (or Secretin) family of proteins. Alone, CALCR binds Calcitonin, the 32 amino acid (aa) founding member of the 5-member Calcitonin family of peptides. When complexed with RAMP family molecules (RAMP-1, -2, or -3), it serves as a receptor for Amylin. CALCR activation inhibits osteoclast-mediated bone resorption and enhances renal calcium excretion. CALCR polymorphisms and mutations have been associated with several bone disorders. Alternative splicing results in an isoform showing an alternate start at Met19. The construct used for antibody production starts at Ala25 of the short form or Ala43 of the full-length form. Human CALCR shares 70%‑72% aa sequence identity with mouse and rat CACLR. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 参考文献 |
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Detection of Calcitonin R in MCF‑7 Human Cell Line by Flow Cytometry. MCF‑7 human breast cancer cell line was stained with Mouse Anti-Human Calcitonin R PE‑conjugated Monoclonal Antibody (Catalog # FAB4614P, filled histogram) or isotype control antibody (Catalog # IC003P, open histogram). View our protocol for Staining Membrane-associated Proteins. |
