Human IL-3 R alpha/CD123 PerCP MAb (Clone 32703) (100 TESTS)【科瑞奥博】

产品中心

当前位置：首页>产品中心

Human IL-3 R alpha/CD123 PerCP MAb (Clone 32703) (100 TESTS)

货号： FAB301C 基本售价： 4382.2 元规格： 100 Tests

产品信息

概述
货号	FAB301C
别名	CD123 antigen; CD123; hIL3Ra; hIL-3Ra; IL-3 receptor subunit alpha; IL-3R subunit alpha; IL3R; IL3RA; IL-3RA; IL-3R-alpha; IL3RAY; IL3RX; IL3RY; interleukin 3 receptor, alpha (low affinity); interleukin-3 receptor subunit alpha; MGC34174
全称	Interleukin 3 Receptor alpha
反应种属	Human
应用	Flow Cytometry(10 µL/10⁶cells)
目标/特异性	Detects human IL‑3 R alpha /CD123 in direct ELISAs and Western blots.
使用方法	Flow Cytometry: 10 µL/10⁶cells
来源	The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
产品组分

性能
供应商	R&D Systems
Entrez Gene IDs	3563 (Human); 16188 (Mouse)
应用文献
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions. A role for IL-25 and IL-33-driven type-2 innate lymphoid cells in atopic dermatitis. Authors: Salimi M, Barlow J, Saunders S, Xue L, Gutowska-Owsiak D, Wang X, Huang L, Johnson D, Scanlon S, McKenzie A, Fallon P, Ogg G J Exp Med, 2013;210(13):2939-50. Species: Human Sample Type: Whole Cells Application: Flow
纯化方式	Protein A or G purified from hybridoma culture supernatant
免疫原	S. frugiperda insect ovarian cell line Sf 21-derived recombinant human IL‑3 R alpha /CD123 Lys20-Arg305, predicted Accession # P26951
生物活性	Human
标记	PerCP
背景	IL-3 is a pleiotropic cytokine that can stimulate proliferation and differentiation of pluripotent hematopoietic stem cells as well as various lineage committed progenitors (1, 2). IL-3 exerts its activity through binding to a specific cell surface receptor known as IL-3 R. IL-3 R is a heterodimeric structure composed of a 70 kDa IL-3 R alpha subunit (CD123) and a 120-140 kDa IL-3 R beta subunit (CD131) (3, 4). IL-3 R alpha binds IL-3 with relatively low affinity. In the presence of IL-3 R beta, however, IL-3 R alpha has a much higher affinity for IL-3. It is not clear how signal transduction occurs following IL-3 binding. The IL-3 R alpha chain has a very short intracellular domain while the IL‑3 R beta chain has a very large cytoplasmic domain. The IL‑3 R beta chain is also shared by the receptors for IL-5 and GM-CSF. Cells known to express IL-3 receptors include hematopoietic progenitors, epithelial cells, double negative T cells, mast cells, basophils and blood monocytes (5).
运输条件	Blue Ice
存放说明	4℃
参考文献	Moore, M.A.S. et al. (1991) Blood 72:944. Warren, D.J. et al. (1988) J. Immunol.140:94. Plant M. et al. (1989) Nature 339:150. Budel, L.M. et al. (1990) Blood 75:1439. Schrader, J.W. et al. (1988) In Interleukin-3: The Panspecific hemopoietin (ed. J.W. Schrader), Academic Press, San Diego, CA.

参考图片

Detection of IL‑3 R alpha /CD123 in Human Blood Lymphocytes by Flow Cytometry. Human peripheral blood lymphocytes were stained with Mouse Anti-Human HLA‑DR PE‑conjugated Monoclonal Antibody (Catalog # FAB4869P) and either (A) Mouse Anti-Human IL‑3 R alpha /CD123 PerCP‑conjugated Monoclonal Antibody (Catalog # FAB301C) or (B) Mouse IgG₁ PerCP Isotype Control (Catalog # IC002C). View our protocol for Staining Membrane-associated Proteins.