Th17-related cytokines contribute to recall-like expansion/effector function of HMBPP-specific Vgamma2Vdelta2 T cells after Mycobacterium tuberculosis infection or vaccination.
Authors: Shen H, Wang Y, Chen C, Frencher J, Huang D, Yang E, Ryan-Payseur B, Chen Z
Eur J Immunol, 2015;45(2):442-51.
Species: Primate - Macaca fascicularis (Crab-eating or Cynomolgus macaque)
Sample Type: Whole Cells
Application: Flow
CX(3)CR1(+) mononuclear phagocytes support colitis-associated innate lymphoid cell production of IL-22.
Authors: Longman R, Diehl G, Victorio D, Huh J, Galan C, Miraldi E, Swaminath A, Bonneau R, Scherl E, Littman D
J Exp Med, 2014;211(8):1571-83.
Species: Human
Sample Type: Whole Cells
Application: Flow
A higher frequency of circulating IL-22(+)CD4(+) T cells in Chinese patients with newly diagnosed Hashimoto's thyroiditis.
Authors: Guo H, Peng D, Yang X, Wang Y, Xu B, Ni J, Meng W, Jiang Y
PLoS ONE, 2014;9(1):e84545.
Species: Human
Sample Type: Whole Cells
Application: Flow
A novel data mining system points out hidden relationships between immunological markers in multiple sclerosis.
Authors: Gironi, Maira, Saresella, Marina, Rovaris, Marco, Vaghi, Matilde, Nemni, Raffaell, Clerici, Mario, Grossi, Enzo
Immun Ageing, 2013;10(1):1.
Species: Human
Sample Type: whole cells
Application: Flow
IL-26 Is Overexpressed in Rheumatoid Arthritis and Induces Proinflammatory Cytokine Production and Th17 Cell Generation.
Authors: Corvaisier M, Delneste Y, Jeanvoine H, Preisser L, Blanchard S, Garo E, Hoppe E, Barre B, Audran M, Bouvard B, Saint-Andre J, Jeannin P
PLoS Biol, 2012;10(9):e1001395.
Species: Human
Sample Type: Whole Cells
Application: Flow
Functionally distinct subsets of human FOXP3+ Treg cells that phenotypically mirror effector Th cells.
Authors: Duhen T, Duhen R, Lanzavecchia A
Blood, 2012;119(19):4430-40.
Species: Human
Sample Type: Whole Cells
Application: Flow
Interleukin-21 induces the differentiation of human Tc22 cells via phosphorylation of signal transducers and activators of transcription.
Authors: Liu Y, Yang B, Ma J, Wang H, Huang F, Zhang J, Chen H, Wu C
Immunology, 2011;132(4):540-8.
Species: Human
Sample Type: Whole Cells
Application: Flow
ESAT-6- and CFP-10-specific Th1, Th22 and Th17 cells in tuberculous pleurisy may contribute to the local immune response against Mycobacterium tuberculosis infection.
Authors: Qiao D, Yang BY, Li L, Ma JJ, Zhang XL, Lao SH, Wu CY
Scand. J. Immunol., 2011;73(4):330-7.
Species: Human
Sample Type: Whole Cells
Application: Flow
IL-22, but not IL-17, dominant environment in cutaneous T-cell lymphoma.
Authors: Miyagaki T, Sugaya M, Suga H, Kamata M, Ohmatsu H, Fujita H, Asano Y, Tada Y, Kadono T, Sato S
Clin. Cancer Res., 2011;17(24):7529-38.
Species: Human
Sample Type: Whole Cells
Application: Flow
Overrepresentation of IL-17A and IL-22 producing CD8 T cells in lesional skin suggests their involvement in the pathogenesis of psoriasis.
Authors: Res PC, Piskin G, de Boer OJ, van der Loos CM, Teeling P, Bos JD, Teunissen MB
PLoS ONE, 2010;5(11):e14108.
Species: Human
Sample Type: Whole Cells
Application: Flow
CD56highCD16-CD62L- NK cells accumulate in allergic contact dermatitis and contribute to the expression of allergic responses.
Authors: Carbone T, Nasorri F, Pennino D
J. Immunol., 2010;184(2):1102-10.
Species: Human
Sample Type: Whole Cells
Application: Flow
Chronic mucocutaneous candidiasis in APECED or thymoma patients correlates with autoimmunity to Th17-associated cytokines.
Authors: Kisand K, Boe Wolff AS, Podkrajsek KT, Tserel L, Link M, Kisand KV, Ersvaer E, Perheentupa J, Erichsen MM, Bratanic N, Meloni A, Cetani F, Perniola R, Ergun-Longmire B, Maclaren N, Krohn KJ, Pura M, Schalke B, Strobel P, Leite MI, Battelino T, Husebye ES, Peterson P, Willcox N, Meager A
J. Exp. Med., 2010;207(2):299-308.
Species: Human
Sample Type: Whole Cells
Application: Flow
Activation of the aryl hydrocarbon receptor reveals distinct requirements for IL-22 and IL-17 production by human T helper cells.
Authors: Ramirez JM, Brembilla NC, Sorg O, Chicheportiche R, Matthes T, Dayer JM, Saurat JH, Roosnek E, Chizzolini C
Eur. J. Immunol., 2010;40(9):2450-9.
Species: Human
Sample Type: Whole Cells
Application: Flow
Stage 3 immature human natural killer cells found in secondary lymphoid tissue constitutively and selectively express the TH 17 cytokine interleukin-22.
Authors: Hughes T, Becknell B, McClory S, Briercheck E, Freud AG, Zhang X, Mao H, Nuovo G, Yu J, Caligiuri MA
Blood, 2009;113(17):4008-10.
Species: Human
Sample Type: Whole Cells
Application: Flow
IL-17 in atopic eczema: linking allergen-specific adaptive and microbial-triggered innate immune response.
Authors: Eyerich K, Pennino D, Scarponi C, Foerster S, Nasorri F, Behrendt H, Ring J, Traidl-Hoffmann C, Albanesi C, Cavani A
J. Allergy Clin. Immunol., 2009;123(1):59-66.e4.
Species: Human
Sample Type: Whole Cells
Application: Flow
Production of interleukin 22 but not interleukin 17 by a subset of human skin-homing memory T cells.
Authors: Duhen T, Geiger R, Jarrossay D, Lanzavecchia A, Sallusto F
Nat. Immunol., 2009;10(8):857-63.
Species: Human
Sample Type: Whole Cells
Application: Flow
Interleukin-17-producing T cells are enriched in the joints of children with arthritis, but have a reciprocal relationship to regulatory T cell numbers.
Authors: Nistala K, Moncrieffe H, Newton KR, Varsani H, Hunter P, Wedderburn LR
Arthritis Rheum., 2008;58(3):875-87.
Species: Human
Sample Type: Whole Cells
Application: Flow
Interleukins 1beta and 6 but not transforming growth factor-beta are essential for the differentiation of interleukin 17-producing human T helper cells.
Authors: Acosta-Rodriguez EV, Napolitani G, Lanzavecchia A, Sallusto F
Nat. Immunol., 2007;8(9):942-9.
Species: Human
Sample Type: Whole Cells
Application: Flow

Interleukin-22 (IL-22), also known as IL-10-related T cell-derived inducible factor (IL-TIF) was initially identified as a gene induced by IL-9 in mouse T cells and mast cells. Human IL-22 cDNA encodes a 179 amino acid (aa) residue protein with a putative 33 aa signal peptide that is cleaved to generate a 147 aa mature protein that shares approximately 79% and 22% aa sequence identity with mouse IL-22 and human IL-10, respectively. The human IL-22 gene is localized to chromosome 12q15. Although it exists as a single copy gene in human and in many mouse strains, the mouse IL-22 gene is duplicated in some mouse strains including C57B1/6, FVB and 129. The two mouse genes designated IL-TIF alpha and IL-TIF beta, share greater than 98% sequence homology in their coding region. IL-22 has been shown to activate STAT1 and STAT3 in several hepatoma cell lines and upregulate the production of acute phase proteins. IL-22 is produced by normal T cells upon anti-CD3 stimulation in humans. Mouse IL-22 expression is also induced in various organs upon lipopolysaccharide injection, suggesting that IL-22 may be involved in inflammatory responses. The functional IL-22 receptor complex consists of two receptor subunits, IL-22 R (previously an orphan receptor named CRF2-9) and IL-10R beta (previously known as CRF2-4), belonging to the class II cytokine receptor family.

1. Dumoutier, L. et al. (2000) J. Immunol. 164:1814.
2. Xie, M-H. et al. (2000) J. Biol. Chem. 275:31335.
3. Dumoutier, L. et al. (2000) Proc. Natl. Acad. Sci. USA 97:10144.
4. Kotenko, S.V. et al. (2001) J. Biol. Chem. 276:2725.