Human B7-H2 Phycoerythrin MAb (Clone 136726) (100 TESTS)【科瑞奥博】

产品中心

当前位置：首页>产品中心

Human B7-H2 Phycoerythrin MAb (Clone 136726) (100 TESTS)

货号： FAB165P 基本售价： 4382.2 元规格： 100 Tests

产品信息

概述
货号	FAB165P
别名	B7H2B7 homolog 2; B7-H2B7-related protein 1; B7RP-1; B7RP1B7-like protein Gl50; B7RP-1LICOS; CD275 antigen; CD275; GL50; GL50transmembrane protein B7-H2 ICOS ligand; ICOSL; ICOS-L; ICOSLG; inducible T-cell co-stimulator ligand; KIAA0653ICOS ligand
全称	B7 Homolog 2
反应种属	Human
应用	Flow Cytometry
目标/特异性	Detects human B7-H2 in direct ELISAs. In direct ELISAs and Western blots, no cross-reactivity with recombinant human (rh) B7-1, rhB7-2, rhB7-H1, rhB7-H3, or recombinant mouse B7-H2 is observed.
使用方法	Flow Cytometry: 10 µL/10⁶cells
来源	The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
产品组分

性能
供应商	R&D Systems
Entrez Gene IDs	23308 (Human); 50723 (Mouse); 102132485 (Cynomolgus Monkey)
应用文献
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions. B7h triggering inhibits the migration of tumor cell lines. Authors: Dianzani C, Minelli R, Gigliotti C, Occhipinti S, Giovarelli M, Conti L, Boggio E, Shivakumar Y, Baldanzi G, Malacarne V, Orilieri E, Cappellano G, Fantozzi R, Sblattero D, Yagi J, Rojo J, Chiocchetti A, Dianzani U J Immunol, 2014;192(10):4921-31. Species: Human Sample Type: Whole Cells Application: Flow
纯化方式	Protein A or G purified from hybridoma culture supernatant
免疫原	Mouse myeloma cell line NS0-derived recombinant human B7-H2 Asp19-Ser258 Accession # O75144
生物活性	Human
标记	Phycoerythrin
背景	Human B7-H2, also called B7RP-1, B7h, LICOS, and GL50, is a 60 kDa member of the B7 family of immune costimulatory proteins, which includes B7-1, B7-2, B7-H1 (PD-L1), PD-L2, and B7-H3. B7 proteins are members of the immunoglobulin (Ig) superfamily, the extracellular domains contain 2 Ig-like domains and all members have short cytoplasmic domains. Family members share about 20‑25% amino acid identity. Within the extracellular domain, human B7-H2 shares 49% and 54% amino acid sequence identity with human and rat B7-H2, respectively. B7-H2 has been identified as the ligand for ICOS, a member of the CD28 family of costimulatory receptors. Human B7-H2 is a 309 amino acid (aa) protein with a putative 18 aa signal peptide, a 239 aa extracellular domain, an 18 aa transmembrane region, and a 33 aa cytoplasmic domain. Human B7-H2 is expressed constitutively on resting B cells, dendritic cells, and at low levels on monocytes. The B7‑H2/ICOS interaction appears to play roles in T cell dependent B cell activation and T_hdifferentiation.
运输条件	Blue Ice
存放说明	4℃
参考文献	Coyle, A.J. and J.C. Gutierrez-Ramos (2001) Nat. Immunol. 2:203. Ling, V. et al. (2000) J. Immunol. 164:1653. Wang, S. et al. (2000) Blood 96:2808. Brodie, D. et al. (2000) Curr. Biol. 10:333. Mages, H.W. et al. (2000) Eur. J. Immunol. 30:1040. Swallow, M.M. et al. (1999) Immunity 11:423. Yoshinaga, S.K. et al. (1999) Nature 402:827.

参考图片

Detection of B7‑H2 in U937 Human Cell Line by Flow Cytometry. U937 human histiocytic lymphoma cell line was stained with Mouse Anti-Human B7‑H2 PE‑conjugated Monoclonal Antibody (Catalog # FAB165P, filled histogram) or isotype control antibody (Catalog # IC0041P, open histogram). View our protocol for Staining Membrane-associated Proteins.