Human TRAIL R4/TNFRSF10D Phycoerythrin MAb (Clone 104918) (100 TESTS)【科瑞奥博】

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Human TRAIL R4/TNFRSF10D Phycoerythrin MAb (Clone 104918) (100 TESTS)

货号： FAB633P 基本售价： 4382.2 元规格： 100 Tests

产品信息

概述
货号	FAB633P
别名	CD264 antigen; CD264; DcR2; DCR2decoy with truncated death domain; Decoy receptor 2; TNF receptor-related receptor for TRAIL; TNF-related apoptosis-inducing ligand receptor 4; TNFRSF10D; TRAIL-R4; TRAILR4TRAIL receptor 4; TRUNDDTRAIL receptor with a truncated death domain; tumor necrosis factor receptor superfamily member 10D; tumor necrosis factor receptor superfamily, member 10d, decoy with truncateddeath domain
全称	TRAIL Receptor 4
反应种属	Human
应用	Flow Cytometry
目标/特异性	Detects human TRAIL R4/TNFRSF10D in ELISAs and Western blots. In sandwich immunoassays, less than 5% cross-reactivity with recombinant human (rh) TRAIL R1, rhTRAIL R2, TRAIL R3, rhTRAIL, rhTNF‑ alpha, and rhTNF-beta is observed.
使用方法	Flow Cytometry: 10 µL/10⁶cells
来源	The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
产品组分

性能
供应商	R&D Systems
Entrez Gene IDs	8793 (Human)
应用文献
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions. Potential application of temozolomide in mesenchymal stem cell-based TRAIL gene therapy against malignant glioma. Authors: Kim, Seong Mu, Woo, Ji Sun, Jeong, Chang Hy, Ryu, Chung He, Jang, Jae-Deog, Jeun, Sin-Soo Stem Cells Transl Med, 2014;3(2):172-82. Species: Human Sample Type: Whole Cells Application: Flow TRAIL(+) human plasmacytoid dendritic cells kill tumor cells in vitro: mechanisms of imiquimod- and IFN-alpha-mediated antitumor reactivity. Authors: Kalb ML, Glaser A, Stary G, Koszik F, Stingl G J. Immunol., 2012;188(4):1583-91. Species: Human Sample Type: Whole Cells Application: Flow Plasmacytoid dendritic cells express TRAIL and induce CD4+ T-cell apoptosis in HIV-1 viremic patients. Authors: Stary G, Klein I, Kohlhofer S, Koszik F, Scherzer T, Mullauer L, Quendler H, Kohrgruber N, Stingl G Blood, 2009;114(18):3854-63. Species: Human Sample Type: Whole Cells Application: Flow Gene therapy using TRAIL-secreting human umbilical cord blood-derived mesenchymal stem cells against intracranial glioma. Authors: Kim SM, Lim JY, Park SI, Jeong CH, Oh JH, Jeong M, Oh W, Park SH, Sung YC, Jeun SS Cancer Res., 2008;68(23):9614-23. Species: Human Sample Type: Whole Cells Application: Flow Tumor necrosis factor-related apoptosis-inducing ligand promotes migration of human bone marrow multipotent stromal cells. Authors: Secchiero P, Melloni E, Corallini F, Beltrami AP, Alviano F, Milani D, DAurizio F, di Iasio MG, Cesselli D, Bagnara GP, Zauli G Stem Cells, 2008;26(11):2955-63. Species: Human Sample Type: Whole Cells Application: Flow Cytokines induced during chronic hepatitis B virus infection promote a pathway for NK cell-mediated liver damage. Authors: Dunn C, Brunetto M, Reynolds G, Christophides T, Kennedy PT, Lampertico P, Das A, Lopes AR, Borrow P, Williams K, Humphreys E, Afford S, Adams DH, Bertoletti A, Maini MK J. Exp. Med., 2007;204(3):667-80. Species: Human Sample Type: Serum Application: Flow
纯化方式	Protein A or G purified from ascites
免疫原	Mouse myeloma cell line NS0-derived recombinant human TRAIL R4/TNFRSF10D Ala56-His211 Accession # Q9UBN6
生物活性	Human
标记	Phycoerythrin
背景	Human TRAIL R4, also called Decoy Receptor 2 (DcR2) and TRUNND (TRAIL Receptor with a Truncated Death Domain), is a type I, TNF R family transmembrane protein, which is a receptor for TRAIL (APO2 Ligand). In the TNF superfamily nomenclature, TRAIL R4 is designated as TNFRSF10D. TRAIL R4 is unique among the TRAIL receptors in that its cytoplasmic domain contains a truncated consensus death domain motif. Binding of TRAIL R4 does not result in an apoptotic signal. Overexpression of TRAIL R4 can protect cells bearing TRAIL R1 and/or TRAIL R2 from TRAIL-mediated apoptosis. The human soluble TRAIL R4/Fc chimera neutralizes the ability of TRAIL to induce apoptosis.
运输条件	Blue Ice
存放说明	4℃
参考文献	Griffith, T.S. et al. (1998) Curr. Opin. Immunol. 10:559. Pan, G. et al. (1998) FEBS lett 424:41. Marsters, S.A. et al. (1997) Cur. Biol. 7:1003. Degli-Esposti, M.A. et al. (1997) Immunity 7:813.

参考图片

Detection of TRAIL R4/TNFRSF10D in Human Blood Granulocytes by Flow Cytometry. Human peripheral blood granulocytes were stained with Mouse Anti-Human TRAIL R4/TNFRSF10D PE‑conjugated Monoclonal Antibody (Catalog # FAB633P, filled histogram) or isotype control antibody (Catalog # IC002P, open histogram). View our protocol for Staining Membrane-associated Proteins.