| 货号 | IC8999G-100UG |
| 别名 | CD288 antigen; CD288; MGC119599; MGC119600; TLR8; toll-like receptor 8 | 全称 | Toll-like Receptor 8 |
| 应用 | Intracellular Staining by Flow Cytometry |
| 目标/特异性 | Detects human TLR8 in direct ELISAs. |
| 使用方法 | Intracellular Staining by Flow Cytometry: 0.25-1 µg/106cells |
| 来源 | Store the unopened product at 2 - 8 °C. Do not use past expiration date. |
| 产品组分 |
| 供应商 | R&D Systems |
| Entrez Gene IDs | 51311 (Human); 170744 (Mouse) |
| 免疫原 | Chinese hamster ovary cell line CHO-derived recombinant human TLR8 Glu27-Thr827 Accession # Q9NR97 |
| 生物活性 | Human |
| 标记 | Alexa Fluor 488 |
| 背景 | TLR8, also designated as CD288 (cluster of differentiation 288),is a member of the toll-like receptor (TLR) family. TLRs make up a family of pattern recognition receptors that playimportant roles in the innate immune response. Broad classes of pathogens (e.g.viruses, bacteria, and fungi) constitutively express a set ofmutation-resistant molecules called pathogen-associated molecular patterns(PAMPs). These microbial molecular markers may be composed of proteins,carbohydrates, lipids, nucleic acids and/or combinations thereof. IndividualTLRs recognize distinct pathogen-associated PAMPs, initiating signaling cascadesthat promote the immune response. Structurally, TLRs are type I transmembranereceptors that possess varying numbers of extracellular N-terminal leucine-richrepeat (LRR) motifs, followed by a cysteine-rich region, a TM domain, and anintracellular Toll/IL-1 R (TIR) motif. The TIR motif is common to the largerIL-1 R/TLR superfamily. Human TLR8 is an endosomal receptor that recognizes singlestranded RNA (ssRNA), and can recognize ssRNA viruses such as Influenza,Sendai, and Coxsackie B viruses. TLR8 binding to the viral RNA recruits MyD88and leads to activation of the transcription factor NF-kB and an antiviralresponse. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 参考文献 |
|