Human IL-10 R alpha Phycoerythrin Affinity Purified PAb (100 TESTS)【科瑞奥博】

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Human IL-10 R alpha Phycoerythrin Affinity Purified PAb (100 TESTS)

货号： FAB6280P 基本售价： 4243.4 元规格： 100 Tests

产品信息

概述
货号	FAB6280P
别名	CD210 antigen; CDw210a; HIL-10R; IBD28; IL-10 receptor subunit alpha; IL-10R subunit 1; IL-10R1; IL10RA; IL-10RA; IL10RIL-10R subunit alpha; interleukin 10 receptor, alpha; interleukin-10 receptor alpha chain; Interleukin-10 receptor subunit 1; interleukin-10 receptor subunit alpha
全称	Interleukin 10 Receptor alpha
反应种属	Human
应用	Flow Cytometry(10 µL/10⁶cells)
目标/特异性	Detects human IL‑10 R alpha in direct ELISAs and Western blots. In direct ELISAs and Western blots, less than 10% cross-reactivity with recombinant mouse IL-10 R alpha and less than 5% cross-reactivity with recombinant human (rh) CNTF sR alpha and rhIL-2 sR gamma is observed.
使用方法	Flow Cytometry: 10 µL/10⁶cells
来源	The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
产品组分

性能
供应商	R&D Systems
Entrez Gene IDs	3587 (Human); 16154 (Mouse)
应用文献
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions. cmvIL-10 stimulates the invasive potential of MDA-MB-231 breast cancer cells. Authors: Valle Oseguera, Cendy A, Spencer, Juliet V PLoS ONE, 2014;9(2):e88708. Species: Human Sample Type: Whole Cells Application: Flow
纯化方式	Antigen Affinity-purified
免疫原	S. frugiperda insect ovarian cell line Sf 21-derived recombinant human IL‑10 R alpha His22-Asn235 Accession # Q13651
生物活性	Human
标记	Phycoerythrin
背景	IL-10, initially designated cytokine synthesis inhibitory factor (CSIF), is a potent immunosuppressant of macrophage functions. IL-10 is also a pleiotropic cytokine with multiple immunostimulatory as well as immunosuppressive effects on a variety of other cell types. IL-10 binds specifically and with high affinity to cell-surface receptors. Mouse and human cDNA clones encoding the ligand-binding IL-10 receptor (IL-10 R) have been isolated. The IL-10 R mRNA has been detected in all cell types that are known to respond to IL-10. Human and mouse IL-10 receptors are structurally related to the IFN-gamma receptor. These receptors are members of the class II subgroup of the cytokine receptor superfamily. The deduced amino acid sequence of human IL-10 R is approximately 60% identical to mouse IL-10 R. Although human IL-10 has cross-species activities and is active on mouse cells, mouse IL-10 is species-specific in its actions and does not bind to the human IL-10 receptor. The human IL-10 R gene has been mapped to chromosome 11q23.3. Recombinant IL-10 soluble receptor, consisting of the extracellular domain of IL-10 R, binds IL-10 with high affinity in solution and is a potent IL-10 antagonist.
运输条件	Blue Ice
存放说明	4℃
参考文献	B Cell Development and Differentiation Cytokines and Receptors in Allergy and Asthma Cytokines and Receptors in Angiogenesis Cytokines and Receptors in Tfh Cell Differentiation and Function Human CD Marker Products ICC / IHC Images: IL-10 R alpha IL-10/Interferon Family Monocyte Markers Neuroinflammation Receptors in the Jak/STAT Pathway Regulatory T Cells (Tregs)

参考图片

Detection of IL‑10 R alpha in Human PBMCs by Flow Cytometry. Human peripheral blood mononuclear cells (PBMCs) were stained with Mouse Anti-Human CD19 APC‑conjugated Monoclonal Antibody (Catalog # FAB4867A) and either (A) Goat Anti-Human
IL‑10 R alpha PE‑conjugated Antigen Affinity-purified Polyclonal Antibody (Catalog # FAB6280P) or (B) Normal Goat IgG Phycoerythrin Control (Catalog # IC108P). View our protocol for Staining Membrane-associated Proteins.