Human TRAIL R3/TNFRSF10C Phycoerythrin MAb (Clone 90906) (100 TESTS)【科瑞奥博】

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Human TRAIL R3/TNFRSF10C Phycoerythrin MAb (Clone 90906) (100 TESTS)

货号： FAB6302P 基本售价： 4243.4 元规格： 100 Tests

产品信息

概述
货号	FAB6302P
别名	Antagonist decoy receptor for TRAIL/Apo-2L; CD263 antigen; CD263; cytotoxic TRAIL receptor-3; DcR1; DCR1MGC149502; Decoy receptor 1; Decoy TRAIL receptor without death domain; LITMGC149501; Lymphocyte inhibitor of TRAIL; TNFRSF10C; TRAIL receptor 3; TRAIL receptor without an intracellular domain; TRAIL-R3; TRAILR3TNF-related apoptosis-inducing ligand receptor 3; TRIDDCR1-TNFR; tumor necrosis factor receptor superfamily member 10C; tumor necrosis factor receptor superfamily, member 10c, decoy without anintracellular domain
全称	TRAIL Receptor 3
反应种属	Human
应用	Flow Cytometry(10 µL/10⁶cells)
目标/特异性	Detects human TRAIL R3/TNFRSF10C in direct ELISAs and Western blots. In direct ELISAs and Western blots, no cross-reactivity with recombinant human (rh) TRAIL R2, rhTRAIL R1, or rhTRAIL R4 is observed.
使用方法	Flow Cytometry: 10 µL/10⁶cells
来源	The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
产品组分

性能
供应商	R&D Systems
Entrez Gene IDs	8794 (Human)
应用文献
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions. Potential application of temozolomide in mesenchymal stem cell-based TRAIL gene therapy against malignant glioma. Authors: Kim, Seong Mu, Woo, Ji Sun, Jeong, Chang Hy, Ryu, Chung He, Jang, Jae-Deog, Jeun, Sin-Soo Stem Cells Transl Med, 2014;3(2):172-82. Species: Human Sample Type: Whole Cells Application: Flow TRAIL(+) human plasmacytoid dendritic cells kill tumor cells in vitro: mechanisms of imiquimod- and IFN-alpha-mediated antitumor reactivity. Authors: Kalb ML, Glaser A, Stary G, Koszik F, Stingl G J. Immunol., 2012;188(4):1583-91. Species: Human Sample Type: Whole Cells Application: Flow Tumor necrosis factor-related apoptosis-inducing ligand promotes migration of human bone marrow multipotent stromal cells. Authors: Secchiero P, Melloni E, Corallini F, Beltrami AP, Alviano F, Milani D, DAurizio F, di Iasio MG, Cesselli D, Bagnara GP, Zauli G Stem Cells, 2008;26(11):2955-63. Species: Human Sample Type: Whole Cells Application: Flow TRAIL recombinant adenovirus triggers robust apoptosis in multidrug-resistant HL-60/Vinc cells preferentially through death receptor DR5. Authors: Wu CH, Kao CH, Safa AR Hum. Gene Ther., 2008;19(7):731-43. Species: Human Sample Type: Whole Cells Application: Flow Gene therapy using TRAIL-secreting human umbilical cord blood-derived mesenchymal stem cells against intracranial glioma. Authors: Kim SM, Lim JY, Park SI, Jeong CH, Oh JH, Jeong M, Oh W, Park SH, Sung YC, Jeun SS Cancer Res., 2008;68(23):9614-23. Species: Human Sample Type: Whole Cells Application: Flow Cytokines induced during chronic hepatitis B virus infection promote a pathway for NK cell-mediated liver damage. Authors: Dunn C, Brunetto M, Reynolds G, Christophides T, Kennedy PT, Lampertico P, Das A, Lopes AR, Borrow P, Williams K, Humphreys E, Afford S, Adams DH, Bertoletti A, Maini MK J. Exp. Med., 2007;204(3):667-80. Species: Human Sample Type: Serum Application: Flow
纯化方式	Protein A or G purified from hybridoma culture supernatant
免疫原	Mouse myeloma cell line NS0-derived recombinant human TRAIL R3/TNFRSF10C Met1-Ala221 Accession # O14798
生物活性	Human
标记	Phycoerythrin
背景	Human TRAIL R3, also known as DcR1 (Decoy Receptor 1), LIT, and TRID, is a glycosyl-phosphatidylinositol-linked membrane protein which binds TRAIL (Apo2 Ligand) with high affinity. In the new TNF superfamily nomenclature, TRAIL R3 is referred to as TNFRSF10C. TRAIL R3 has the TRAIL-binding extracellular cysteine-rich domains but lacks the intracellular signalling domain. As a result, binding of TRAIL to TRAIL R3 does not transduce an apoptosis signal. Expression of TRAIL R3 has been shown to protect cells bearing TRAIL R1 and/or TRAIL R2 from TRAIL-induced apoptosis. A second TRAIL decoy receptor, which binds TRAIL with high-affinity but antagonizes TRAIL-induced apoptosis, named TRAIL R4, DcR2 or TRUNDD, has also been reported. The human soluble TRAIL R3/Fc chimera neutralizes the ability of TRAIL to induce apoptosis.
运输条件	Blue Ice
存放说明	4℃
参考文献	Sheridan, J.P.et al. (1997) Science 277:818. Golstein, P. (1997) Curr. Biol. 7:R750.

参考图片

Detection of TRAIL R3/TNFRSF10C in Human Blood Granulocytes by Flow Cytometry. Human peripheral blood granulocytes were stained with Mouse Anti-Human TRAIL R3/TNFRSF10C PE‑conjugated Monoclonal Antibody (Catalog # FAB6302P, filled histogram) or isotype control antibody (Catalog # IC002P, open histogram). View our protocol for Staining Membrane-associated Proteins.