The role of selected flavonols in tumor necrosis factor-related apoptosis-inducing ligand receptor-1 (TRAIL-R1) expression on activated RAW 264.7 macrophages.
Authors: Warat M, Sadowski T, Szliszka E, Krol W, Czuba Z
Molecules, 2015;20(1):900-12.
Species: Mouse
Sample Type: Whole Cells
Application: Flow
Potential application of temozolomide in mesenchymal stem cell-based TRAIL gene therapy against malignant glioma.
Authors: Kim, Seong Mu, Woo, Ji Sun, Jeong, Chang Hy, Ryu, Chung He, Jang, Jae-Deog, Jeun, Sin-Soo
Stem Cells Transl Med, 2014;3(2):172-82.

Smad7 protein induces interferon regulatory factor 1-dependent transcriptional activation of caspase 8 to restore tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-mediated apoptosis.
Authors: Hong S, Kim H, Kim J, Ha H, Kim Y, Bae E, Kim T, Lee K, Kim S
J Biol Chem, 2013;288(5):3560-70.
Species: Human
Sample Type: whole cells
Application: Flow
Azadirone, a limonoid tetranortriterpene, induces death receptors and sensitizes human cancer cells to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) through a p53 protein-independent mechanism: evidence for the role of the ROS-ERK-CHOP-death receptor pathway.
Authors: Gupta, Subash C, Francis, Sajin K, Nair, Mangalam, Mo, Yin-Yuan, Aggarwal, Bharat B
J Biol Chem, 2013;288(45):32343-56.
Species: Human
Sample Type: Whole Cells
Application: Flow
TRAIL(+) human plasmacytoid dendritic cells kill tumor cells in vitro: mechanisms of imiquimod- and IFN-alpha-mediated antitumor reactivity.
Authors: Kalb ML, Glaser A, Stary G, Koszik F, Stingl G
J. Immunol., 2012;188(4):1583-91.
Species: Human
Sample Type: Whole Cells
Application: Flow
The dietary flavonol fisetin enhances the apoptosis-inducing potential of TRAIL in prostate cancer cells.
Authors: Szliszka E, Helewski KJ, Mizgala E, Krol W
Int. J. Oncol., 2011;39(4):771-9.
Species: Human
Sample Type: Whole Cells
Application: Flow
Drozitumab, a human antibody to death receptor 5, has potent antitumor activity against rhabdomyosarcoma with the expression of caspase-8 predictive of response.
Authors: Kang Z, Chen J, Yu Y, Li B, Sun S, Zhang B, Cao L
Clin Cancer Res, 2011;17(10):3181-92.
Species: Human
Sample Type: Whole Cells
Application: Flow
Epigenetic silencing of death receptor 4 mediates tumor necrosis factor-related apoptosis-inducing ligand resistance in gliomas.
Authors: Elias A, Siegelin MD, Steinmuller A, von Deimling A, Lass U, Korn B, Mueller W
Clin. Cancer Res., 2009;15(17):5457-65.
Species: Human
Sample Type: Whole Cells
Application: Flow
TRAIL recombinant adenovirus triggers robust apoptosis in multidrug-resistant HL-60/Vinc cells preferentially through death receptor DR5.
Authors: Wu CH, Kao CH, Safa AR
Hum. Gene Ther., 2008;19(7):731-43.
Species: Human
Sample Type: Whole Cells
Application: Flow
Tumor necrosis factor-related apoptosis-inducing ligand promotes migration of human bone marrow multipotent stromal cells.
Authors: Secchiero P, Melloni E, Corallini F, Beltrami AP, Alviano F, Milani D, DAurizio F, di Iasio MG, Cesselli D, Bagnara GP, Zauli G
Stem Cells, 2008;26(11):2955-63.
Species: Human
Sample Type: Whole Cells
Application: Flow
Gene therapy using TRAIL-secreting human umbilical cord blood-derived mesenchymal stem cells against intracranial glioma.
Authors: Kim SM, Lim JY, Park SI, Jeong CH, Oh JH, Jeong M, Oh W, Park SH, Sung YC, Jeun SS
Cancer Res., 2008;68(23):9614-23.
Species: Human
Sample Type: Whole Cells
Application: Flow
Cytokines induced during chronic hepatitis B virus infection promote a pathway for NK cell-mediated liver damage.
Authors: Dunn C, Brunetto M, Reynolds G, Christophides T, Kennedy PT, Lampertico P, Das A, Lopes AR, Borrow P, Williams K, Humphreys E, Afford S, Adams DH, Bertoletti A, Maini MK
J. Exp. Med., 2007;204(3):667-80.
Species: Human
Sample Type: Serum
Application: Flow

Human TRAIL R1, also called DR4, is a type 1, TNF R family, membrane protein which is a receptor for TRAIL (APO2 ligand). In the TNF superfamily nomenclature, TRAIL RI is referred to as TNFRSF10A. TRAIL R1 cDNA encodes a 468 amino acid precursor protein containing extracellular cysteine-rich domains, a transmembrane domain and a cytoplasmic death domain. Among the TNF receptor family proteins, TRAIL R1 is most closely related to TRAIL R2/DR5, sharing 55% amino acid sequence identity. Binding of trimeric TRAIL to TRAIL R1 induces apoptosis. The induction of apoptosis likely requires oligomerization of the receptor. The human TRAIL R1/Fc chimera neutralizes the ability of TRAIL to induce apoptosis. Besides TRAIL R1, an additional TRAIL R2/DR5, which tranduces apoptosis signal, and two TRAIL decoy receptors, which antagonize TRAIL-induced apoptosis, have been reported.

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