Human CCL17/TARC Phycoerythrin MAb (Clone 54015) (100 TESTS)【科瑞奥博】

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Human CCL17/TARC Phycoerythrin MAb (Clone 54015) (100 TESTS)

货号： IC3641P 基本售价： 4243.4 元规格： 100 Tests

产品信息

概述
货号	IC3641P
别名	ABCD-2; CC chemokine TARC; C-C motif chemokine 17; chemokine (C-C motif) ligand 17; MGC138273; SCYA17MGC138271; small inducible cytokine subfamily A (Cys-Cys), member 17; Small-inducible cytokine A17; T cell-directed CC chemokine; TARC; TARCA-152E5.3; Thymus and activation-regulated chemokine
反应种属	Human
应用	Intracellular Staining by Flow Cytometry(10 µL/10⁶cells)
目标/特异性	Detects human CCL17/TARC in direct ELISAs and Western blots. In direct ELISAs and Western blots, no cross-reactivity with recombinanthuman CCL1, 2, 3, 4, 5, 7, 8, 11, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24,25, 26, 27, 28, recombinant mouse CCL1, 2, 3, 4, 5, 6, 7, 8, 9, 11, 12, 17, 19,20, 21, 22, 24, 25, 27 or recombinant rat CCL20 is observed.
使用方法	Intracellular Staining by Flow Cytometry: 10 µL/10⁶cells
来源	The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
产品组分

性能
供应商	R&D Systems
Entrez Gene IDs	6361 (Human); 20295 (Mouse)
应用文献
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions. SHP-1 deficiency and increased inflammatory gene expression in PBMCs of multiple sclerosis patients. Authors: Christophi GP, Hudson CA, Gruber RC, Christophi CP, Mihai C, Mejico LJ, Jubelt B, Massa PT Lab. Invest., 2008;88(3):243-55. Species: Human Sample Type: Whole Cells Application: Flow CCL17 and CCL22 chemokines within tumor microenvironment are related to accumulation of Foxp3+ regulatory T cells in gastric cancer. Authors: Mizukami Y, Kono K, Kawaguchi Y, Akaike H, Kamimura K, Sugai H, Fujii H Int. J. Cancer, 2008;122(10):2286-93. Species: Human Sample Type: Whole Cells Application: Flow
纯化方式	Protein A or G purified from ascites
免疫原	E. coli-derived recombinant human CCL17/TARC Ala24-Ser94 Accession # Q92583.1
生物活性	Human
标记	Phycoerythrin
背景	CCL17, also called TARC, is a member of the CC chemokine family. CCL17 cDNA encodes a highly basic 94 amino acid (aa) residue precursor protein with a 23 aa residue signal peptide that is cleaved to generate the 71 aa residue mature secreted protein. Among CC chemokine family members, CCL17 has approximately 24‑29% amino acid sequence identity with CCL1, 2, 3, 4, 5, 7 and 8. The gene for human CCL17 has been mapped to chromosome 16q13 rather than chromosome 17 where the genes for many human CC chemokines are clustered. CCL17 is constitutively expressed in thymus, and at a lower level in lung, colon, and small intestine. CCL17 is also transiently expressed in stimulated peripheral blood mononuclear cells. Recombinant CCL17 has been shown to be chemotactic for T cell lines but not monocytes or neutrophils. CCL17 was identified to be a specific functional ligand for CCR4, a receptor that is selectively expressed on T cells.
运输条件	Blue Ice
存放说明	4℃
参考文献	Imai, T. et al. (1997) J. Biol. Chem. 272:15036. Imai, T.et al. (1996) J. Biol. Chem. 271:21514. Nomiyama, H. et al. (1997) Genomics 40:211.

参考图片

Detection of CCL17/TARC in A549 Human Cell Line by Flow Cytometry. A549 human lung carcinoma cell line was stained with Mouse Anti-Human CCL17/TARC PE‑conjugated Monoclonal Antibody (Catalog # IC3641P, filled histogram) or isotype control antibody (Catalog # IC002P, open histogram). To facilitate intracellular staining, cells were fixed with Flow Cytometry Fixation Buffer (Catalog # FC004) and permeabilized with Flow Cytometry Permeabilization/Wash Buffer I (Catalog # FC005). View our protocol for Staining Intracellular Molecules.