Human IL-2 Fluorescein MAb (Clone 5334) (100 TESTS)【科瑞奥博】

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Human IL-2 Fluorescein MAb (Clone 5334) (100 TESTS)

货号： IC202F 基本售价： 4243.4 元规格： 100 Tests

产品信息

概述
货号	IC202F
别名	aldesleukin; IL-2lymphokine; interleukin 2; interleukin-2; involved in regulation of T-cell clonal expansion; T cell growth factor; T-cell growth factor; TCGF
全称	Interleukin 2
反应种属	Human
应用	Intracellular Staining by Flow Cytometry(10 µL/10⁶cells)
目标/特异性	Detects human IL-2 in direct ELISAs. Does not cross-react with recombinant IL-2 from mouse, rat, pig, or cotton rat.
使用方法	Intracellular Staining by Flow Cytometry: 10 µL/10⁶cells
来源	The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
产品组分

性能
供应商	R&D Systems
Entrez Gene IDs	3558 (Human); 16183 (Mouse); 116562 (Rat); 396868 (Porcine); 280822 (Bovine); 403989 (Canine); 100034204 (Equine); 751114 (Feline); 100302458 (Rabbit)
应用文献
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions. Expression of the T cell receptor alpha/beta on a CD123+ BDCA2+ HLA-DR+ subpopulation in head and neck squamous cell carcinoma. Authors: Thiel A, Kesselring R, Pries R, Puzik A, Wittkopf N, Wollenberg B PLoS ONE, 2011;6(1):e15997. Species: Human Sample Type: Whole Cells Application: Flow Analysis of CD4+ T-Cell responses to a novel alpha-fetoprotein-derived epitope in hepatocellular carcinoma patients. Authors: Alisa A, Ives A, Pathan AA, Navarrete CV, Williams R, Bertoletti A, Behboudi S Clin. Cancer Res., 2005;11(18):6686-94. Species: Human Sample Type: Whole Cells Application: Flow
纯化方式	Protein A or G purified from hybridoma culture supernatant
免疫原	E. coli-derived recombinant human IL‑2 Ala21-Thr153 Accession # NP_000577
生物活性	Human
标记	Fluorescein
背景	IL-2 is a 15-19 kDa secreted O-glycosylated polypeptide that belongs to the gamma _c -receptor utilizing family of molecules. It is a monomer that is expressed by a limited number of cell types, including CD4⁺ and CD8⁺ T cells, gamma δ T cells, eosinophils and B cells. Its local concentration, plus the stoichiometry of it receptor ( a two or three subunit complex) appears to determine what effects it has on its target cells. It is suggested to both induce NK and CD8⁺ T cell proliferation, and promote NK cell and CD8⁺ T cell effector activity. IL-2 also appears to drive CD4⁺ Fox P3^- thymocytes into mature FoxP3⁺ Tregs, and to direct the conversion of CD4⁺ T cells into induced Tregs. Finally, IL-2 induces gamma δ T cells to secrete IFN-gamma, and endothelial cells to upregulate endocytic activity. Human and mouse IL-2 share 56 % amino acid sequence identity.
运输条件	Blue Ice
存放说明	4℃
参考文献	BIObrief: Common gamma-Chain Family Cytokines Play a Pivotal Role in Regulating Immune System Functions Cancer Biomarkers Common gamma Chain Receptor Family Common gamma-Chain Family Cytokines Play a Pivotal Role in Regulating Immune System Functions Conventional/Classical Dendritic Cells Cytokines and Receptors in Allergy and Asthma Cytokines and Receptors in Tfh Cell Differentiation and Function gamma delta T Cells Group 1 ILCs ICC / IHC Images: IL-2 Infectious Diseases Inflammatory Mediators Interactive Pathway: IL-2 Signaling and its Primary Biological Effects in Different Immune Cell Types Interactive Pathway: IL-2 Signaling Pathways Isolation, Culture, and Identification of Natural Killer Cells Mini-review: Cytolytic Granule-mediated Apoptosis Multiple Sclerosis and Myelin Related Molecules NCR+ILC3 Neuroinflammation Preeclampsia Regulatory T Cells (Tregs) T Cell Cytokine Signaling Th1 Cells Th2 Cells Th9 Cells

参考图片

Detection of IL‑2 in Human PBMCs treated with PMA and Ca²⁺ ionomycin by Flow Cytometry. Human peripheral blood mononuclear cells (PBMCs) were treated with PMA and Ca²⁺ ionomycin stained with Mouse Anti-Human IL‑2 Fluorescein‑conjugated Monoclonal Antibody (Catalog # IC202F, filled histogram) or isotype control antibody (Catalog # IC002F, open histogram). View our protocol for Staining Intracellular Molecules.