Human CXCR4 Phycoerythrin MAb (Clone 44717) (100 TESTS)【科瑞奥博】

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Human CXCR4 Phycoerythrin MAb (Clone 44717) (100 TESTS)

货号： FAB173P-100 基本售价： 4243.4 元规格： 100 Tests

产品信息

概述
货号	FAB173P-100
别名	CD184; chemokine (C-X-C motif) receptor 4; chemokine (C-X-C motif), receptor 4 (fusin); C-X-C chemokine receptor type 4; CXC-R4; CXCR-4; D2S201ESDF-1 receptor; FB22; Fusin; HM89NPYRL; HSY3RR; LAP3; LCR1; LESTRCD184 antigen; Leukocyte-derived seven transmembrane domain receptor; leukocyte-derived seven-transmembrane-domain receptor; lipopolysaccharide-associated protein 3; neuropeptide Y receptor Y3; NPY3RWHIM; NPYR; NPYY3R; seven transmembrane helix receptor; seven-transmembrane-segment receptor, spleen; Stromal cell-derived factor 1 receptor
反应种属	Human
应用	Flow Cytometry(10 µL/10⁶cells)
目标/特异性	Reacts specifically with human and non-human cells expressing human CXCR4 (fusin) as detected by flow cytometry. It will also react with cells expressing feline CXCR4 but not rat CXCR4. This antibody does not cross-react with other chemokine receptors.
使用方法	Flow Cytometry: 10 µL/10⁶cells
来源	The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
产品组分

性能
供应商	R&D Systems
Entrez Gene IDs	7852 (Human); 12767 (Mouse); 60628 (Rat); 483900 (Canine); 493676 (Feline)
应用文献
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions. Thymoquinone inhibits the CXCL12-induced chemotaxis of multiple myeloma cells and increases their susceptibility to Fas-mediated apoptosis. Authors: Badr G, Lefevre EA, Mohany M PLoS ONE, 2011;6(9):e23741. Species: Human Sample Type: Whole Cells Application: Flow Protein kinase C and NF-kappaB-dependent CD4 downregulation in macrophages induced by T cell-derived soluble factors: consequences for HIV-1 infection. Authors: Raposo RA, Trudgian DC, Thomas B, van Wilgenburg B, Cowley SA, James W J. Immunol., 2011;187(2):748-59. Species: Human Sample Type: Whole Cells Application: Flow Human melanoma metastases express functional CXCR4. Authors: Scala S, Giuliano P, Ascierto PA, Ierano C, Franco R, Napolitano M, Ottaiano A, Lombardi ML, Luongo M, Simeone E, Castiglia D, Mauro F, De Michele I, Calemma R, Botti G, Caraco C, Nicoletti G, Satriano RA, Castello G Clin. Cancer Res., 2006;12(8):2427-33. Species: Human Sample Type: Whole Cells Application: Flow Phenotypic and functional analysis of T cells homing into the CSF of subjects with inflammatory diseases of the CNS. Authors: Giunti D, Borsellino G, Benelli R, Marchese M, Capello E, Valle MT, Pedemonte E, Noonan D, Albini A, Bernardi G, Mancardi GL, Battistini L, Uccelli A J. Leukoc. Biol., 2003;73(5):584-90. Species: Human Sample Type: Whole Cells Application: Flow Mutations at the CXCR4 interaction sites for AMD3100 influence anti-CXCR4 antibody binding and HIV-1 entry. Authors: Hatse S, Princen K, Vermeire K, Gerlach LO, Rosenkilde MM, Schwartz TW, Bridger G, De Clercq E, Schols D FEBS Lett., 2003;546(2):300-6. Species: Human Sample Type: Whole Cells Application: Flow Clonal Th2 cells associated with chronic hypereosinophilia: TARC-induced CCR4 down-regulation in vivo. Authors: de Lavareille A, Roufosse F, Schandene L, Stordeur P, Cogan E, Goldman M Eur. J. Immunol., 2001;31(4):1037-46. Species: Human Sample Type: Whole Cells Application: Flow
纯化方式	Protein A or G purified from ascites
免疫原	Mouse 3T3 cells transfected with human CXCR4
生物活性	Human
标记	Phycoerythrin
背景	CXCR4 is a G-protein-linked seven transmembrane spanning receptor thatbinds stromal cell-derived factor-1 (SDF-1). CXCR4 acts as a co-factorfor T-cell tropic HIV-1 and -2 viral entry into cells.
运输条件	Blue Ice
存放说明	4℃
参考文献	Acute Myeloid Leukemia B Cell Chemotaxis, Migration, and Adhesion B Cell Markers Cancer Biomarkers Cancer Stem Cell Markers Chemokine Receptors Chemokines and Receptors in Allergy and Asthma Chemokines and Receptors in Angiogenesis Chemokines and Receptors in Tfh Cell Differentiation and Function CXCR4: A Receptor for Extracellular Ubiquitin Cytokine Upregulation of HIV Coreceptors Endothelial Cell Differentiation Markers Endothelial Progenitor and Endothelial Cell Markers Endothelial Progenitor Cell Markers gamma delta T Cells Hematopoietic Stem Cell Markers Hepatic Endoderm Hepatic Endoderm Cell Markers HIF Transcription Factors Human CD Marker Products Infectious Diseases Megakaryocytes Neural Stem Cell Markers Neuroinflammation Receptors in the Jak/STAT Pathway Regulatory T Cells (Tregs) Somite Markers T Cell Migration/Adhesion Th2 Cells

参考图片

Detection of CXCR4 in Human Blood Lymphocytes by Flow Cytometry. Human peripheral blood lymphocytes were stained with Mouse Anti-Human CXCR4 PE‑conjugated Monoclonal Antibody (Catalog # FAB173P) and Mouse Anti-Human CD19 APC‑conjugated Monoclonal Antibody (Catalog # FAB4867A). View our protocol for Staining Membrane-associated Proteins.