Human IL-13 R alpha 1 Phycoerythrin MAb (Clone 419718) (100 TESTS)【科瑞奥博】

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Human IL-13 R alpha 1 Phycoerythrin MAb (Clone 419718) (100 TESTS)

货号： FAB1462P 基本售价： 4243.4 元规格： 100 Tests

产品信息

概述
货号	FAB1462P
别名	bB128O4.2.1 (interleukin 13 receptor, alpha 1); Cancer/testis antigen 19; CD213a1 antigen; CD213a1; CT19; IL13 receptor alpha-1 chain; IL-13 receptor subunit alpha-1; IL-13R subunit alpha-1; IL13R; IL13RA; IL-13Ra; IL13RA1; IL-13RA1; IL-13R-alpha-1; interleukin 13 receptor, alpha 1; interleukin-13 receptor subunit alpha-1; NR4
全称	Interleukin 13 Receptor alpha 1
反应种属	Human
应用	Flow Cytometry(10 µL/10⁶cells)
目标/特异性	Detects human IL-13 R alpha 1 in direct ELISAs and Western blots. In direct ELISAs and Western blots, no cross-reactivity with recombinant mouse IL-13 R alpha 1, recombinant human (rh) IL-13 R alpha 2, rhIL-4 R, rhIL-5 R beta, or rhIL-9 R is observed.
使用方法	Flow Cytometry: 10 µL/10⁶cells
来源	The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
产品组分

性能
供应商	R&D Systems
Entrez Gene IDs	3597 (Human); 16164 (Mouse)
应用文献
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions. Suppression of human glioma xenografts with second-generation IL13R-specific chimeric antigen receptor-modified T cells. Authors: Kong S, Sengupta S, Tyler B, Bais A, Ma Q, Doucette S, Zhou J, Sahin A, Carter B, Brem H, Junghans R, Sampath P Clin Cancer Res, 2012;18(21):5949-60. Species: Human Sample Type: whole cells Application: Flow
纯化方式	Protein A or G purified from hybridoma culture supernatant
免疫原	Mouse myeloma cell line NS0-derived recombinant human IL‑13 R alpha 1 Ala27-Thr343 Accession # P78552
生物活性	Human
标记	Phycoerythrin
背景	Two type 1 membrane proteins belonging to the hemopoietin receptor family have been cloned and shown to bind IL-13 with differing affinities. The lower affinity IL-13 binding protein, previously designated IL-13 R alpha, IL-13 R alpha or NR4, is now referred to as IL-13 R alpha 1. The high-affinity IL-13 binding protein, previously also designated IL-13 R or IL-13 R alpha , is now referred to as IL-13 R alpha 2. The human IL-13 R alpha 1 was originally cloned based on sequence homology to the mouse IL-13 R alpha 1. The IL-13 R alpha 1 cDNA encodes a 427 amino acid (aa) precursor protein with a putative 21 aa signal peptide, a 324 aa extracellular domain, a 23 aa transmembrane region and a 59 aa cytoplasmic tail. Human and mouse IL-13 R alpha 1 share 76% aa sequence identity. The extracellular domain of IL-13 R alpha 1 is also closely related to that of IL-13 R alpha 2. IL‑13 R alpha 1 has been shown to combine with the IL-4 R alpha to form a high-affinity receptor complex capable of transducing an IL-13-dependent proliferative signal. The role of IL-13 R alpha 2 in IL-13 signaling remains to be elucidated.
运输条件	Blue Ice
存放说明	4℃
参考文献	Caput, D.et al. (1996) J. Biol. Chem. 271:16921. Donaldson, D.D.et al. (1998) J. Immunol. 161:2317. Aman, M.J.et al. (1996) J. Biol. Chem. 271:29265. Hilton, D.J.et al. (1996) Proc. Natl. Acad. Sci. USA 93:497. Zhang, J.G.et al. (1997) J. Biol. Chem. 272:9474.

参考图片

Detection of IL‑13 R alpha 1 in Human Blood Granulocytes by Flow Cytometry. Human peripheral blood granulocytes were stained with (A) MouseAnti-Human Siglec-3/CD33 APC-conjugated Monoclonal Antibody (Catalog # FAB1137A) and (B) Mouse Anti-Human IL‑13 R alpha 1 PE‑conjugated Monoclonal Antibody (Catalog # FAB1462P, filled histogram) or isotype control antibody (Catalog # IC0041P, open histogram). View our protocol for Staining Membrane-associated Proteins.