概述| 货号 | FAB099P |
| 别名 | BLT1; chemokine receptor-like 1; CMKRL1; leukotriene B4 receptor; LTB4R; LTB4R1; LTBR1; P2Y purinoceptor 7; purinergic receptor P2Y, G-protein coupled, 7 |
全称 | Leukotriene B4 Receptor 1 | | 反应种属 | Human |
| 应用 | Flow Cytometry(10 µL/106cells)
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| 目标/特异性 | Recognizes human Leukotriene B4 R1 (5). |
| 使用方法 | Flow Cytometry: 10 µL/106cells
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| 来源 | The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below. |
| 产品组分 | |
性能| 供应商 | R&D Systems |
| Entrez Gene IDs | 1241 (Human) |
| 应用文献 |
| R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions. Expression of enzymes and receptors of the leukotriene pathway in human neuroblastoma promotes tumor survival and provides a target for therapy.
Authors: Sveinbjornsson B, Rasmuson A, Baryawno N, Wan M, Pettersen I, Ponthan F, Orrego A, Haeggstrom JZ, Johnsen JI, Kogner P
FASEB J., 2008;22(10):3525-36.
Species: Human
Sample Type: Whole Cells
Application: Flow
Residues from transmembrane helices 3 and 5 participate in leukotriene B4 binding to BLT1.
Authors: Sabirsh A, Bywater RP, Bristulf J, Owman C, Haeggstrom JZ
Biochemistry, 2006;45(18):5733-44.
Species: Human
Sample Type: Whole Cells
Application: Flow |
| 纯化方式 | Protein A or G purified from hybridoma culture supernatant |
| 免疫原 | HeLa cervical epithelial carcinoma cell line transfected with human Leukotriene B4 R1 |
| 生物活性 | Human |
| 标记 | Phycoerythrin |
| 背景 | Polymorphonuclear granulocytes secrete the lipid chemotactic mediator Leukotriene B4 (LTB4) in response to inflammatory stimuli (1). Neutrophils, monocytes and lymphocytes respond to LTB4 via specific receptors localized on the cell surface (2-4). The high affinity LTB4 Receptor known as BLT1 is only expressed on leukocytes (5-7) while a second low affinity receptor BLT2 is expressed more ubiquitously (8, 9). The BLT1 and BLT2 are G-protein linked seven-transmembrane spanning receptors that share about 37-45% amino acid identity (8, 9). Enhanced LTB4 production and engagement of the BLT receptors can be important in allergic and inflammatory diseases such as asthma (10), allergic encephalomyelitis (11), endotoxic shock (12), ischemia (12), psoriasis (13), rheumatoid arthritis (14) and inflammatory bowel disease (15). In addition, it has been reported that BLT1 can function as an additional co-receptor for HIV infection of CD4+ T cells (16, 17). Investigations into the mechanisms and potential inhibitors of LTB4 binding to its’ receptors may provide insight into possible treatment modalities for a number of inflammatory disorders. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 参考文献 | - Samuelsson, B. et al. (1987) Science 237:1171.
- Brom, J. and W. Konig (1989) Immunology 68:479.
- Patry, C. et al. (1996) Prostaglandins, Leukotrienes and Essential Fatty Acids 54:361.
- Dasari, V.R. et al. (2000) Immunopharm. 48:157.
- Pettersson, A. et al. (2000) Biochem. Biophys. Res. Comm. 279:520.
- Yokomizo, T. et al. (1997) Nature 387:620.
- Kato, K. et al. (2000) J. Exp. Med. 192:413.
- Yokomizo, T. et al. (2000) J. Exp. Med. 192:421.
- Kamohara, M. et al. (2000) J. Biol. Chem. 275:27000.
- Turner, C.R. et al. (1996) J. Clin. Invest. 97:381.
- Gladue, R.P. et al. (1996) J. Exp. Med. 183:1893.
- Lefer, A.M. (1986) Biochem. Pharmacol. 35:123.
- Iverson, L. et al. (1997) Skin Pharmacol. 10:169.
- Griffiths, R.J. et al. (1995) Proc. Natl. Acad. Sci. USA 92:517.
- Sharon, P. and W.F. Stenson (1984) Gastroenterology 86:453.
- Owman, C. et al. (1996) Proc. Natl. Acad. Sci. USA 95:9530.
- Martin, V. et al. (1999) J. Biol. Chem. 274:8597.
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