Human TACI/TNFRSF13B Phycoerythrin MAb (Clone 165604) (100 TESTS)【科瑞奥博】

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Human TACI/TNFRSF13B Phycoerythrin MAb (Clone 165604) (100 TESTS)

货号： FAB1741P 基本售价： 4243.4 元规格： 100 Tests

产品信息

概述
货号	FAB1741P
简介	Clone 165604 was used by HLDA to establish CD designation
别名	CD267 antigen; CD267; CVID; CVID2; FLJ39942; MGC133214; TACIMGC39952; TNFRSF13B; TNFRSF14B; Transmembrane activator and CAML interactor; tumor necrosis factor receptor 13B; tumor necrosis factor receptor superfamily member 13B; tumor necrosis factor receptor superfamily, member 13B
全称	Transmembrane Activator and CAML Interactor/Tumor Necrosis Factor Receptor Superfamily Member 13B
反应种属	Human
应用	Flow Cytometry
目标/特异性	Detects human TACI/TNFRSF13B in direct ELISAs. In direct ELISAs, no cross-reactivity with recombinant human BCMA or recombinant mouse TACI is observed.
使用方法	Flow Cytometry: 10 µL/10⁶cells
来源	The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
产品组分

性能
供应商	R&D Systems
Entrez Gene IDs	23495 (Human); 57916 (Mouse)
应用文献
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions. Control of Viremia Enables Acquisition of Resting Memory B Cells with Age and Normalization of Activated B Cell Phenotypes in HIV-Infected Children. Authors: Muema D, Macharia G, Hassan A, Mwaringa S, Fegan G, Berkley J, Nduati E, Urban B J Immunol, 2015;195(3):1082-91. Species: Human Sample Type: Whole Cells Application: Flow The immunoregulator soluble TACI is released by ADAM10 and reflects B cell activation in autoimmunity. Authors: Hoffmann F, Kuhn P, Laurent S, Hauck S, Berer K, Wendlinger S, Krumbholz M, Khademi M, Olsson T, Dreyling M, Pfister H, Alexander T, Hiepe F, Kumpfel T, Crawford H, Wekerle H, Hohlfeld R, Lichtenthaler S, Meinl E J Immunol, 2015;194(2):542-52. Species: Human Sample Type: Whole Cells Application: Flow Altered B-cell homeostasis and excess BAFF in human chronic graft-versus-host disease. Authors: Sarantopoulos S, Stevenson KE, Kim HT, Cutler CS, Bhuiya NS, Schowalter M, Ho VT, Alyea EP, Koreth J, Blazar BR, Soiffer RJ, Antin JH, Ritz J Blood, 2009;113(16):3865-74. Species: Human Sample Type: Whole Cells Application: Flow BAFF and APRIL expression in B-cell chronic lymphocytic leukemia: correlation with biological and clinical features. Authors: Bojarska-Junak A, Hus I, Chocholska S, Wasik-Szczepanek E, Sieklucka M, Dmoszynska A, Rolinski J Leuk. Res., 2009;33(10):1319-27. Species: Human Sample Type: Whole Cells Application: Flow Role of B-cell-activating factor in adhesion and growth of human multiple myeloma cells in the bone marrow microenvironment. Authors: Tai YT, Li XF, Breitkreutz I, Song W, Neri P, Catley L, Podar K, Hideshima T, Chauhan D, Raje N, Schlossman R, Richardson P, Munshi NC, Anderson KC Cancer Res., 2006;66(13):6675-82. Species: Human Sample Type: Whole Cells Application: Flow
纯化方式	Protein A or G purified from hybridoma culture supernatant
免疫原	Mouse myeloma cell line NS0-derived recombinant human TACI/TNFRSF13B Ser2-Thr166 Accession # O14836
生物活性	Human
标记	Phycoerythrin
背景	TACI (Transmembrane Activator and CAML-Interactor) is a 30-32 kDa member of the TNF receptor superfamily. It is classified as is a type III membrane protein with an extracellular N‑terminus in the absence of a cleaved signal sequence. The extracellular region of TACI contains two cysteine rich domains. Within the TNFRSF, it shares the highest homology with BCMA. TACI and BCMA have both been shown to bind APRIL and BAFF, members of the TNF ligand superfamily. TACI is expressed on the cell surface of B cells and activated, but not resting, T cells. Analogous to BCMA, data suggests that TACI may play an important role in B cell development, function and regulation. Human TACI is a 293 amino acid (aa) protein consisting of a 166 aa extracellular domain, a 20 aa transmembrane domain, and a 107 aa intracellular domain. Human and mouse TACI share 54% amino acid identity.
运输条件	Blue Ice
存放说明	4℃
参考文献	B Cell Development and Differentiation B Cell Markers Co-stimulatory and Co-inhibitory Molecules Human CD Marker Products ICC / IHC Images: TACI/TNFRSF13B Regulation of Apoptosis by TNF Superfamily Members Regulation of B Cell Activation and Homeostasis by TNF Superfamily Members Regulation of T Cell Co-stimulation by TNF Superfamily Members TNF Superfamily TNF Superfamily Receptors

参考图片

Detection of TACI/TNFRSF13B in Human Peripheral Blood Lymphocytes by Flow Cytometry. Human peripheral blood lymphocytes were stained with Mouse Anti-Human TACI/TNFRSF13B PE‑conjugated Monoclonal Antibody (Catalog # FAB1741P) and Mouse Anti-Human CD19 Fluorescein‑conjugated Monoclonal Antibody (Catalog # FAB4867F). Quadrant markers were set based on control antibody staining (Catalog # IC002P). View our protocol for Staining Membrane-associated Proteins.

Detection of TACI/TNFRSF13B in Raji Human Cell Line by Flow Cytometry. Raji human Burkitts lymphoma cell line was stained with Mouse Anti-Human TACI/TNFRSF13B PE‑conjugated Monoclonal Antibody (Catalog # FAB1741P, filled histogram) or isotype control antibody (Catalog # IC002P, open histogram). View our protocol for Staining Membrane-associated Proteins.