Interferon Alpha Induces Sustained Changes in NK Cell Responsiveness to Hepatitis B Viral Load Suppression In Vivo
PLoS Pathog, 2016;12(8):e1005788.
Species: Human
Sample Type: Whole Cells
Application: Flow
NKP30-B7-H6 Interaction Aggravates Hepatocyte Damage through Up-Regulation of Interleukin-32 Expression in Hepatitis B Virus-Related Acute-On-Chronic Liver Failure.
Authors: Zou Y, Bao J, Pan X, Lu Y, Liao S, Wang X, Wang G, Lin D
PLoS ONE, 2015;10(8):e0134568.
Species: Human
Sample Type: Whole Cells
Application: Flow
Up-regulation of activating and inhibitory NKG2 receptors in allogeneic and autologous hematopoietic stem cell grafts.
Authors: Picardi A, Mengarelli A, Marino M, Gallo E, Benevolo M, Pescarmona E, Cocco R, Fraioli R, Tremante E, Petti M, De Fabritiis P, Giacomini P
J Exp Clin Cancer Res, 2015;34(0):98.
Species: Human
Sample Type: Whole Cells
Application: Flow
Human Induced Pluripotent Stem Cells Are Targets for Allogeneic and Autologous Natural Killer (NK) Cells and Killing Is Partly Mediated by the Activating NK Receptor DNAM-1.
Authors: Kruse V, Hamann C, Monecke S, Cyganek L, Elsner L, Hubscher D, Walter L, Streckfuss-Bomeke K, Guan K, Dressel R
PLoS ONE, 2015;10(5):e0125544.
Species: Human
Sample Type: Whole Cells
Application: Flow
Natural killer (NK) cells inhibit systemic metastasis of glioblastoma cells and have therapeutic effects against glioblastomas in the brain.
Authors: Lee S, Kang W, Yoon Y, Jin J, Song H, Her J, Kang S, Hwang Y, Kang K, Joo K, Nam D
BMC Cancer, 2015;15(1):1011.
Species: Human
Sample Type: Whole Cells
Application: Flow
An epithelial cell adhesion molecule- and CD3-bispecific antibody plus activated T-cells can eradicate chemoresistant cancer stem-like pancreatic carcinoma cells in vitro.
Authors: Umebayashi M, Kiyota A, Koya N, Tanaka H, Onishi H, Katano M, Morisaki T
Anticancer Res, 2014;34(8):4509-19.
Species: Human
Sample Type: Whole Cells
Application: Flow
NKG2D-directed cytokine-activated killer lymphocyte therapy combined with gemcitabine for patients with chemoresistant metastatic solid tumors.
Authors: Morisaki T, Hirano T, Koya N, Kiyota A, Tanaka H, Umebayashi M, Onishi H, Katano M
Anticancer Res, 2014;34(8):4529-38.
Species: Human
Sample Type: Whole Cells
Application: Flow
Natural killer cells are characterized by the concomitantly increased interferon-gamma and cytotoxicity in acute resolved hepatitis B patients.
Authors: Zhao J, Li Y, Jin L, Zhang S, Fan R, Sun Y, Zhou C, Shang Q, Li W, Zhang Z, Wang F
PLoS ONE, 2012;7(11):e49135.
Species: Human
Sample Type: Whole Cells
Application: Flow
Expression profiles of novel cell surface molecules on B-cell subsets and plasma cells as analyzed by flow cytometry.
Authors: Llinas L, Lazaro A, de Salort J, Matesanz-Isabel J, Sintes J, Engel P
Immunol. Lett., 2011;134(2):113-21.
Species: Human
Sample Type: Whole Cells
Application: Flow
Natural killer cells from children with type 1 diabetes have defects in NKG2D-dependent function and signaling.
Authors: Qin H, Lee IF, Panagiotopoulos C, Wang X, Chu AD, Utz PJ, Priatel JJ, Tan R
Diabetes, 2011;60(3):857-66.
Species: Human
Sample Type: Whole Cells
Application: Flow
Combinatorial Cytotoxicity of Gemcitabine and Cytokine-activated Killer Cells in Hepatocellular Carcinoma via the NKG2D-MICA/B System.
Authors: Morisaki T, Onishi H, Koya N
Anticancer Res., 2011;31(7):2505-10.
Species: Human
Sample Type: Whole Cells
Application: Flow
Phenotype markers and cytokine intracellular production by CD8+ gammadelta T lymphocytes do not support a regulatory T profile in Behcet's disease patients and healthy controls.
Authors: Clemente A, Cambra A, Munoz-Saa I, Crespi C, Pallares L, Juan A, Matamoros N, Julia MR
Immunol. Lett., 2010;129(2):57-63.
Species: Human
Sample Type: Whole Cells
Application: Flow
Expression of the ULBP ligands for NKG2D by B-NHL cells plays an important role in determining their susceptibility to rituximab-induced ADCC.
Authors: Inagaki A, Ishida T, Yano H, Ishii T, Kusumoto S, Ito A, Ri M, Mori F, Ding J, Komatsu H, Iida S, Ueda R
Int. J. Cancer, 2009;125(1):212-21.
Species: Human
Sample Type: Whole Cells
Application: Flow
Binding of excreted and/or secreted products of adult hookworms to human NK cells in Necator americanus-infected individuals from Brazil.
Authors: Teixeira-Carvalho A, Fujiwara RT, Stemmy EJ, Olive D, Damsker JM, Loukas A, Correa-Oliveira R, Constant SL, Bethony JM
Infect. Immun., 2008;76(12):5810-6.
Species: Human
Sample Type: Whole Cells
Application: Flow
Functional impairment in circulating and intrahepatic NK cells and relative mechanism in hepatocellular carcinoma patients.
Authors: Cai L, Zhang Z, Zhou L, Wang H, Fu J, Zhang S, Shi M, Zhang H, Yang Y, Wu H, Tien P, Wang FS
Clin. Immunol., 2008;129(3):428-37.
Species: Human
Sample Type: Whole Cells
Application: Flow
Endometrial NK cells are special immature cells that await pregnancy.
Authors: Manaster I, Mizrahi S, Goldman-Wohl D, Sela HY, Stern-Ginossar N, Lankry D, Gruda R, Hurwitz A, Bdolah Y, Haimov-Kochman R, Yagel S, Mandelboim O
J. Immunol., 2008;181(3):1869-76.
Species: Human
Sample Type: Whole Cells
Application: Flow
Generation, affinity maturation, and characterization of a human anti-human NKG2D monoclonal antibody with dual antagonistic and agonistic activity.
Authors: Kwong KY, Baskar S, Zhang H, Mackall CL, Rader C
J. Mol. Biol., 2008;384(5):1143-56.
Species: Human
Sample Type: Whole Cells
Application: Flow
4-1BB regulates NKG2D costimulation in human cord blood CD8+ T cells.
Authors: Kim YJ, Han MK, Broxmeyer HE
Blood, 2007;111(3):1378-86.
Species: Human
Sample Type: Whole Cells
Application: Flow
Phosphostim-activated gamma delta T cells kill autologous metastatic renal cell carcinoma.
Authors: Viey E, Fromont G, Escudier B, Morel Y, Da Rocha S, Chouaib S, Caignard A
J. Immunol., 2005;174(3):1338-47.
Species: Human
Sample Type: Whole Cells
Application: Flow

NKG2D is a type II transmembrane glycoprotein having an extracellular lectin-like domain. This domain lacks the recognizable calcium-binding sites found in true C‑type lectins and binds protein rather than carbohydrate ligands. Human NKG2D is expressed on CD8⁺ alpha beta T cells, gamma δ T cells, NK cells, and NKT cells. In mouse systems NKG2D also occurs on macrophages. Human ligands for NKG2D include MICA, MICB, and ULBP1, 2, and 3. Expression of NKG2D ligands occurs in epithelial cells, tumor cells and under conditions of stress or infection. NKG2D exists as a disulfide-linked homodimer that delivers an activating signal upon ligand binding. Signaling requires association with an adapter protein. Alternative splicing of the NKG2D mRNA results in isoforms with different cytoplasmic domains that can associate either with DAP12 to deliver a true activating signal or with DAP10 resulting in a costimulatory signal. NKG2D has been implicated in anti-tumor surveillance and the immune response against viral infection.

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