Human CCR6 Alexa Fluor 594 MAb (Clone 53103) (100 TESTS)【科瑞奥博】

产品中心

当前位置：首页>产品中心

Human CCR6 Alexa Fluor 594 MAb (Clone 53103) (100 TESTS)

货号： FAB195T-100 基本售价： 4094.7 元规格： 100 Tests

产品信息

概述
货号	FAB195T-100
简介	Clone 53103 was used by HLDA to establish CD designation
别名	BN-1; CC-CKR-6; CCR6; CCR-6; CD196 antigen; CD196; chemokine (C-C motif) receptor 6; CKR-L3G-protein coupled receptor 29; CKRL3LARC receptor; CMKBR6STRL22; DRY6; GPR29; GPR29C-C CKR-6; GPR-CY4; GPRCY4DRY-6; lymphocyte, 22; STRL22
应用	Flow Cytometry(5 µL/10⁶cells)
目标/特异性	Detects human CCR6. Stains human CCR6 transfectants but not the parental cell line in flow cytometry. Does not cross-react with transfectants expressing human CCR1, CCR2, CCR3, CCR4, CCR5, CCR7, CXCR1, CXCR2, CXCR3, CXCR4, or STRL33.
使用方法	Flow Cytometry: 5 µL/10⁶cells
来源	The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
产品组分

性能
供应商	R&D Systems
Entrez Gene IDs	1235 (Human); 12458 (Mouse); 308163 (Rat)
纯化方式	Protein A or G purified from ascites
免疫原	NS0 mouse myeloma cell line transfected with human CCR6 Met1-Met374 Accession # P51684
生物活性	Human
标记	Alexa Fluor 594
背景	Human CCR6 (C-C Chemokine Receptor 6) is a 45-50 kDa member of the G-protein coupled receptor #1 family. It is a 374 amino acid (aa) 7-transmembrane glyocprotein that is responsive to a limited number of ligands, including CCL20/MIP-3 alpha and the beta -Defensins HBD-1 and -2. A large number of cell types express CCR6, which in human include neutrophils, spermatogonia, intestinal epithelial columnar cells, osteoblasts, IL-17 secreting CD161⁺CCR6⁺ TCR-V alpha 7.2 CD8⁺ Tcells, monocytes, macrophages, CD4⁺CCR4⁺CXCR3^-CCR6⁺ IL-17 secreting Th17 cells, CD4⁺CCR4^-CXCR3⁺CCR6⁺ IL-17 secreting and IFN-gamma secreting Th1 Th17 cells and hepatic carcinoma plus colon carcinoma cells. On mouse cells, CCR6 is found on CD4⁺CD25⁺CD45RO⁺ memory Tregs, CD4^-CD8^-CD25^-CD44⁺c-Kit⁺CCR6⁺ double-negative thymocytes, and CD116⁺CCR6⁺ dendritic cells plus CD11c⁺B220⁺CD19⁺IgM⁺CCR6⁺ Peyers Patch B cells. CCR6 activity may be cell or environment specific, and actions described to date include the promotion of cell proliferation, the downregulation of IL-12 production, and chemotaxis. The extracellular domains of human and mouse CCR6 share 52% aa sequence identity.
运输条件	Blue Ice
存放说明	4℃
参考文献	B Cell Chemotaxis, Migration, and Adhesion CC Chemokines and Receptors Chemokine Receptors Chemokines and Receptors in Allergy and Asthma Chemokines and Receptors in Angiogenesis Dendritic Cell Adhesion and Migration gamma delta T Cells Human CD Marker Products LTi Cells Monocyte Markers Natural Killer T (NKT) Cells Regulatory T Cells (Tregs) T Cell Migration/Adhesion Th17 Cells Th22 Cells

参考图片

Detection of CCR6 in Human PBMCs by Flow Cytometry. Human peripheral blood mononuclear cells (PBMCs) were stained with Mouse Anti-Human CD19 APC‑conjugated Monoclonal Antibody (Catalog # FAB4867A) and either (A) Mouse Anti-Human CCR6 Alexa Fluor® 594‑conjugated Monoclonal Antibody (Catalog # FAB195T) or (B) Mouse IgG_2B Alexa Fluor 594 Isotype Control (Catalog # IC0041T). View our protocol for Staining Membrane-associated Proteins.