Human DC-SIGNR/CD299 Phycoerythrin MAb (Clone 120604) (100 TESTS)【科瑞奥博】

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Human DC-SIGNR/CD299 Phycoerythrin MAb (Clone 120604) (100 TESTS)

货号： FAB162P 基本售价： 3955.9 元规格： 100 Tests

产品信息

概述
货号	FAB162P
简介	Clone 120604 was used by HLDA to establish CD designation
别名	CD209L; CD209L1; CD209Ldendritic cell-specific ICAM-3-grabbing nonintegrin 2; CD299 antigenMGC129964; CD299; CLEC4M; C-type lectin domain family 4, member M; DC-SIGN2; DC-SIGN2CD209 antigen-like protein 1; DC-SIGNRDC-SIGN-related protein; DCSIGNRMGC47866; Dendritic cell-specific ICAM-3-grabbing non-integrin 2; HP10347; liver/lymph node-specific ICAM-3 grabbing non-integrin; Liver/lymph node-specific ICAM-3-grabbing non-integrin; LSIGN; L-SIGN; LSIGNC-type lectin domain family 4 member M; mannose binding C-type lectin DC-SIGNR
全称	Dendritic Cell-specific ICAM-3-grabbing Non-integrin 2
反应种属	Human
应用	Flow Cytometry
目标/特异性	Detects human DC‑SIGNR/CD299.
使用方法	Flow Cytometry: 10 µL/10⁶cells
来源	The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
产品组分

性能
供应商	R&D Systems
Entrez Gene IDs	10332 (Human)
应用文献
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions. Mechanism and significance of cell type-dependent neutralization of flaviviruses. Authors: Mukherjee S, Dowd K, Manhart C, Ledgerwood J, Durbin A, Whitehead S, Pierson T J Virol, 2014;88(13):7210-20. Species: Human Sample Type: Whole Cells Application: Flow Endogenously expressed nef uncouples cytokine and chemokine production from membrane phenotypic maturation in dendritic cells. Authors: Messmer D, Jacque JM, Santisteban C, Bristow C, Han SY, Villamide-Herrera L, Mehlhop E, Marx PA, Steinman RM, Gettie A, Pope M J. Immunol., 2002;169(8):4172-82. Species: Human Sample Type: Whole Cells Application: Flow
纯化方式	Protein A or G purified from hybridoma culture supernatant
免疫原	NIH-3T3 mouse embryonic fibroblast cell line transfected with human DC‑SIGNR/CD299 Accession # Q9H2X3
生物活性	Human
标记	Phycoerythrin
背景	Dendritic cell-specific ICAM-3 grabbing non-integrin (DC-SIGN or CD299) and DC-SIGN related protein (DC-SIGNR, DC-SIGN2, L-SIGN or CD209L) are type II membrane proteins that are mannose-specific calcium-dependent (C-type) lectins. The two proteins share 77% amino acid identity. DC-SIGN mediates interactions between dendritic cells (DCs) and T cells. Both DC-SIGN and DC-SIGNR have been shown to bind HIV, hepatitis C glycoproteins, Ebola virus glycoproteins and the cellular adhesion protein ICAM-3 (1-4). DC-SIGN and DC-SIGNR appear to selectively recognize and bind viral proteins containing a large portion of high-mannose oligosaccharides (5). Though DC-SIGN and DC-SIGNR are found on the same chromosome, they are not expressed in the same tissue. DC-SIGN is expressed solely on Dendritic cells while DC-SIGNR is found on endothelial cells in the liver and lymph node sinuses and in a significant portion of capillary endothelial cells in term placenta (1, 4).
运输条件	Blue Ice
存放说明	4℃
参考文献	Pohlmann, S. et al. (2001) Proc. Natl. Acad. Sci. USA 98:2670. Pohlmann, S. et al. (2003) J. Virol. 77:4070. Simmons, L.G. et al. (2003) J. Virol. 77:1337. Bahirova, A.A. et al. (2001) J. Exp. Med. 193:671. Feinberg, H. et al. (2001) Science 294:2163.

参考图片

Detection of DC‑SIGNR/CD299 in 3T3 Mouse Cell Line Transfected with Human DC-SIGNR/CD299 by Flow Cytometry. 3T3 mouse embryonic fibroblast cell line transfected with human DC-SIGNR/CD299 was stained with Mouse Anti-Human DC‑SIGNR/CD299 PE‑conjugated Monoclonal Antibody (Catalog # FAB162P, filled histogram) or isotype control antibody (Catalog # IC0041P, open histogram). View our protocol for Staining Membrane-associated Proteins.