| 货号 | IC4645V-100UG |
| 别名 | G protein-coupled receptor 50H9Mel1c; GPR50; H9; melatonin-related receptor; MGC125342; MTR1L | 全称 | G Protein-coupled Receptor 50 |
| 应用 | Intracellular Staining by Flow Cytometry |
| 目标/特异性 | Detects human GPR50. Stains human GPR50 transfectants but not irrelevant transfectants. |
| 使用方法 | Intracellular Staining by Flow Cytometry: 0.25-1 µg/106cells |
| 来源 | The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below. |
| 产品组分 |
| 供应商 | R&D Systems |
| Entrez Gene IDs | 9248 (Human); 14765 (Mouse); 117097 (Rat) |
| 免疫原 | NS0 mouse myeloma cell line transfected with human GPR50 Met1-Val617 Accession # Q13585 |
| 生物活性 | Human |
| 标记 | Alexa Fluor 405 |
| 背景 | GPR50, also known as MTR1L, is a non-glycosylated seven-transmembrane G protein-coupled receptor that is related to the melatonin receptors MT1 and MT2. GPR50 is expressed in the hippocampus, hypothalamus, and pituitary and forms 130 kDa homodimers. It heterodimerizes with either MT1 or MT2, resulting in inhibition of MT1 but not MT2 function. An alternately spliced isoform of GPR50 has a 4 aa deletion in the large C-terminal cytoplasmic domain. The presence of this deletion as well as various polymorphisms have been associated with elevated serum triglyceride and HDL levels. The deletion may also be associated with the development of bipolar disorder. Human GPR50 shares approximately 70% amino acid sequence identity with mouse and rat GPR50. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 参考文献 |
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