货号 | IC4514V-100UG |
别名 | glutamate receptor, metabotropic 5; GPRC1E; GPRC1EMGLUR5metabotropic glutamate receptor 5; GRM5; mGlu5; mGluR5 | 全称 | Metabotropic Glutamate Receptor 5 |
应用 | Intracellular Staining by Flow Cytometry |
目标/特异性 | Detects human mGluR5 in direct ELISAs and Western blots. In direct ELISAs and Western blots, no cross-reactivity with recombinant human mGluR1, R2, R3, R4, R7, or R8 is observed. |
使用方法 | Intracellular Staining by Flow Cytometry: 0.25-1 µg/106cells |
来源 | The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below. |
产品组分 |
供应商 | R&D Systems |
Entrez Gene IDs | 2915 (Human); 108071 (Mouse); 24418 (Rat) |
免疫原 | Mouse myeloma cell line NS0-derived recombinant human mGluR5 Gln21-Ser509 Accession # P41594 |
生物活性 | Human |
标记 | Alexa Fluor 405 |
背景 | Human metabotropic glutamate receptor 5 (mGluR5; also mGluR5b) is a 150 kDa 7-transmembrane glycoprotein that belongs to group I of the C-family of G-protein coupled receptors. mGluR5 is constitutively expressed and regulates neuronal ion channel activity. Human mGluR5 is 1212 aa in length and contains an extracellular domain (ECD) of 558 amino acids. Through its ECD, mGluR5 either homodimerizes or heterodimerizes with the Ca++-sensor receptor. There is one alternate splice form (mGluR5a) that shows a 32 aa deletion between aa 877‑908 in the cytoplasmic tail. Over aa 19‑509, human mGluR5 is 98% aa identical to mouse, rat, and dog mGluR5. |
运输条件 | Blue Ice |
存放说明 | 4℃ |
参考文献 |
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