| 货号 | IC3657T-100UG |
| 别名 | EC 3.4.24; EC 3.4.24.-; EC 3.4.24.24; matrix metallopeptidase 11 (stromelysin 3); matrix metalloproteinase 11 (stromelysin 3); Matrix metalloproteinase-11; MMP11; MMP-11; SL-3; ST3; STMY3stromelysin 3; stromelysin III; stromelysin-3 | 全称 | Matrix Metalloproteinase 11 |
| 应用 | Intracellular Staining by Flow Cytometry |
| 目标/特异性 | Detects human MMP-11 in direct ELISAs. |
| 使用方法 | Intracellular Staining by Flow Cytometry: 0.25-1 µg/106cells |
| 来源 | The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below. |
| 产品组分 |
| 供应商 | R&D Systems |
| Entrez Gene IDs | 4320 (Human) |
| 免疫原 | E. coli-derived recombinant human MMP‑11 Met1-Leu488 Accession # P24347 |
| 生物活性 | Human |
| 标记 | Alexa Fluor 594 |
| 背景 | MMP-11, also called Stromelysin-3, is a metalloproteinase secreted by cells of mesenchymal origin. Human MMP-11 contains a 31 amino acid (aa) signal sequence, a 65 aa propeptide cleaved at a furin consensus sequence, and a 390 aa mature sequence with zinc metalloproteinase and hemopexin-like domains. The human 45 kDa mature MMP-11 shows 89% aa identity with mouse. An inducible low-abundance 40 kDa isoform is a constitutively active intracellular form. MMP-11 is upregulated in stromal cells near many invasive carcinomas, where it can cleave IGFBP, allowing IGF-1 to promote tumor cell growth. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 参考文献 |
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