| 货号 | IC17841N-100UG |
| 别名 | EC 3.4.24; EC 3.4.24.71; ECE; ECE1; ECE-1; endothelin converting enzyme 1; endothelin-converting enzyme 1 | 全称 | Endothelin-converting Enzyme-1 |
| 应用 | Intracellular Staining by Flow Cytometry |
| 目标/特异性 | Detects human ECE-1 in direct ELISAs. |
| 使用方法 | Intracellular Staining by Flow Cytometry: 0.25-1 µg/106cells |
| 来源 | The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below. |
| 产品组分 |
| 供应商 | R&D Systems |
| Entrez Gene IDs | 1889 (Human) |
| 免疫原 | Mouse myeloma cell line NS0-derived recombinant human ECE-1 Gln90-Trp770 Accession # P42892 |
| 生物活性 | Human |
| 标记 | Alexa Fluor 700 |
| 背景 | Endothelin-converting Enzyme 1 (ECE-1) is a zinc protease of the neprilysin (NEP) family, which also includes ECE-2, PEX, XCE, DINE, Kell and several NEP-like proteins (1). ECE-1 is a type II transmembrane protein with a short cytoplasmic tail and a large ectodomain. Four alternatively spliced isoforms differ in their cytoplasmic tail (2, 3). In addition to big endothelin-1, ECE-1 cleaves a variety of bioactive peptides such as bradykinin, neurotensin, angiotensin I, and substance P (1). Together with ECE-2, it is also involved in degradation of beta -amyloid peptide (4). The ectodomain of human ECE-1, which is common to all isoforms, was expressed with an N-terminal His tag and purified. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 参考文献 |
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