货号 | IC1584V-100UG |
别名 | signal transducer and activator of transcription 5B; STAT5; STAT5b; transcription factor STAT5B | 全称 | Signal Transducer and Activator of Transcription 5b |
应用 | Intracellular Staining by Flow Cytometry |
目标/特异性 | Detects human STAT5b in Western blots. |
使用方法 | Intracellular Staining by Flow Cytometry: 0.25-1 µg/106cells |
来源 | The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below. |
产品组分 |
供应商 | R&D Systems |
Entrez Gene IDs | 6777 (Human); 20851 (Mouse) |
免疫原 | Human STAT5b synthetic peptide MDSQWIPHAQS Accession # NP_036580 |
生物活性 | Human |
标记 | Alexa Fluor 405 |
背景 | Signal Transduction and Activator of Transcription 5B (STAT5b) is a member of the Jak/STAT signal transduction pathway and is activated by a variety of cytokines (IL-22, IL-6, IFN alpha ). Upon cytokine activation, STAT5b is phosphorylated and translocates to the nucleus where it binds to the DNA consensus site TTCN3GAA and activates transcription of specific genes. STAT5b shares 93% amino acid identity with STAT5a. STAT5b is involved in a wide array of biological processes ranging from regulating apoptosis to adult mammary gland proliferation, differentiation and survival. |
运输条件 | Blue Ice |
存放说明 | 4℃ |
参考文献 |
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