| 货号 | FAB7219S-100UG |
| 别名 | CLEC2A C-type lectin domain family 2, member A ; CLEC2A; CLEC-2A; KACL; PILAR; UNQ5792 | 全称 | C-type Lectin Domain Family 2, Member A |
| 应用 | Flow Cytometry |
| 目标/特异性 | Detects human CLEC-2A in direct ELISAs. In direct ELISAs, no cross-reactivity with recombinanthuman (rh) CLEC-2D, rhCLEC-2, or rhCD69 is observed. |
| 使用方法 | Flow Cytometry: 0.25-1 µg/106cells |
| 来源 | The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below. |
| 产品组分 |
| 供应商 | R&D Systems |
| Entrez Gene IDs | 387836 (Human) |
| 免疫原 | Mouse myeloma cell line NS0-derived recombinant human CLEC-2A Trp49-Leu174 (predicted) Accession # Q6UVW9 |
| 生物活性 | Human |
| 标记 | Alexa Fluor 750 |
| 背景 | CLEC-2A (C-type lectin domain family 2 member A), also known as PILAR and KACL, is an approximately 35 kDa type II transmembrane glycoprotein in the C-type lectin superfamily. It contains one C-type lectin domain in its extracellular region. Alternate splicing of human CLEC-2A generates an additional isoform with a substitution of 37 amino acids (aa) at the C-terminus. CLEC-2A is upregulated on antigen-activated CD8+ T cells and enhances T cell proliferation through interactions with CD161. It is also expressed on keratinocytes and binds to NKp65/KLRF2, triggering NK cell activation. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 参考文献 |
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