| 货号 | FAB53851N-100UG |
| 简介 | Recombinant Monoclonal Antibody |
| 别名 | Tbet; T-bet; TBETT-PET; TBLYM; TBLYMT-cell-specific T-box transcription factor T-bet; T-box 21; T-box expressed in T cells; T-box protein 21; T-box transcription factor TBX21; TBX21; T-PET; Transcription factor TBLYM | 全称 | T-box transcription factor TBX21 |
| 应用 | Intracellular Staining by Flow Cytometry |
| 目标/特异性 | Detects human T‑bet/TBX21 in direct ELISAs. |
| 使用方法 | Intracellular Staining by Flow Cytometry: 0.25-1 µg/106cells |
| 来源 | The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below. |
| 产品组分 |
| 供应商 | R&D Systems |
| Entrez Gene IDs | 30009 (Human); 57765 (Mouse); 303496 (Rat) |
| 纯化方式 | Protein A or G purified from cell culture supernatant |
| 免疫原 | E. coli-derived recombinant human T‑bet/TBX21 Glu326-Asn535 Accession # Q9UL17 |
| 生物活性 | Human |
| 标记 | Alexa Fluor 700 |
| 背景 | T-box expressed in T cells (T-bet), also known as T-box transcription factor TBX21, is a 62 kDa member of the T-box family of transcription factors and the Tbr1 subfamily. Human T-bet is 535 amino acids in length and contains a T-box DNA binding domain (aa 136-327). Human T-bet shares 88% aa sequence identity with mouse T-bet. T-bet is a nuclear protein highly apparent in Th1 cells. Northern blot analysis revealed that it is also expressed in lung, thymus and spleen. Functionally, T-bet controls the expression of the Th1 cytokine, IFN-gamma, and initiates Th1 lineage development from naïve Th precursor cells by both activating Th1 genetic programs and by repressing the opposing Th2 programs. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 参考文献 |
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