| 货号 | FAB5149R-100UG |
| 别名 | A disintegrin and metalloproteinase with thrombospondin motifs 15; a disintegrin-like and metalloprotease (reprolysin type) with thrombospondintype 1 motif, 15; a disintegrin-like and metalloprotease (reprolysin type) with thrombospondintype 1 motif, 15, preproprotein; ADAM metallopeptidase with thrombospondin type 1 motif, 15; ADAM-TS 15; ADAMTS15; ADAM-TS15; ADAMTS-15; EC 3.4.24; EC 3.4.24.-; EC 3.4.24.14; EC 3.4.24.82; metalloprotease disintegrin 15 with thrombospondin domains; MGC126403 | 全称 | A Disintegrin-like and Metalloproteinase Domain with Thrombospondin Motifs 15 |
| 应用 | Flow Cytometry |
| 目标/特异性 | Detects human ADAMTS15 in direct ELISAs and Western blots. |
| 使用方法 | Flow Cytometry: 0.25-1 µg/106cells |
| 来源 | The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below. |
| 产品组分 |
| 供应商 | R&D Systems |
| Entrez Gene IDs | 170689 (Human); 235130 (Mouse); 300474 (Rat) |
| 免疫原 | Chinese hamster ovary cell line CHO-derived recombinant human ADAMTS15 Gly18-Cys682 Accession # Q8TE58 |
| 生物活性 | Human |
| 标记 | Alexa Fluor 647 |
| 背景 | A disintegrin and metalloproteinase with thrombospondin motifs 15 (ADAMTS15) is a secreted multi-domain protease that is primarily expressed in fetal liver and kidney. ADAMTS1, 4, 5, 8, and 15 form a subfamily of ADAMTS proteases that possess aggrecanase activity. These proteins are synthesized as zymogens which have a pro-domain that is removed by furin-like protein convertases. ADAMTS15 functions as a suppressor of tumor growth and invasion. It is downregulated in colon cancer, and its expression in breast cancer correlates with poor prognosis. Within amino acids (aa) 18-682 (which includes the propeptide, peptidase, disintegrin, first TSP-1 and most of the Cys-rich domain), human ADAMTS15 shares 95% aa sequence identity with mouse and rat ADAMTS15. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 参考文献 |
|