| 货号 | FAB4788U-100UG |
| 别名 | EWI-3; glu-Trp-Ile EWI motif-containing protein 3; IGSF3; immunoglobulin superfamily, member 3; member 3; V8 | 全称 | Immunoglobulin Superfamily, Member 3 |
| 应用 | Flow Cytometry |
| 目标/特异性 | Detects human IGSF3 in direct ELISAs. In direct ELISAs, no cross-reactivity with recombinant human (rh) IGSF4, 4B, 4C, 4D or 8 is observed. |
| 使用方法 | Flow Cytometry: 0.25-1 µg/106cells |
| 来源 | The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below. |
| 产品组分 |
| 供应商 | R&D Systems |
| Entrez Gene IDs | 3321 (Human); 78908 (Mouse); 295325 (Rat) |
| 免疫原 | Mouse myeloma cell line NS0-derived recombinant human IGSF3 Gln20-Ala1125 Accession # AAI44133 |
| 生物活性 | Human |
| 标记 | Alexa Fluor 350 |
| 背景 | IGSF3 (Immunoglobulin superfamily member 3; also EWI-3) is a 133 kDa (predicted) member of the EWI subfamily of the Ig-Superfamily of molecules. It is reported to be widely expressed, with concentration in placenta and lung. Human IGSF3 an 1194 amino acid (aa) type I transmembrane protein that contains a 19 aa signal sequence followed by a 1175 aa mature region (aa 20-1194). The molecules extracellular region is 1105 aa in length (aa 20-1124), and contains eight C2-type Ig-like domains (aa 22-1097). This region also possesses at least two utilized phosphorylation sites at Thr617and Ser625, plus an EWI motif in the second Ig-like domain. IGSF3 likely exists as a disulfide-linked homodimer. There are two potential isoform variants. One contains a 20 aa insertion after Pro406, while another shows the same insert coupled to a premature truncation after Pro833. Over aa 20‑1125, human IGSF3 shares 92% aa identity with mouse IGSF3. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 参考文献 |
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