Human Cadherin-12 Alexa Fluor 700 Antibody (Clone 343621) (100 UG)【科瑞奥博】

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Human Cadherin-12 Alexa Fluor 700 Antibody (Clone 343621) (100 UG)

货号： FAB2240N-100UG 基本售价： 3817.0 元规格： 100 UG

产品信息

概述
货号	FAB2240N-100UG
别名	Br-Cadherin; cadherin 12, type 2 (N-cadherin 2); Cadherin12; Cadherin-12; CDH12; CDHB; FLJ34857; N-Cadherin 2; Neural type cadherin 2; neural type, 2; neuronal cadherin 2
应用	Flow Cytometry
目标/特异性	Detects human Cadherin‑12 in direct ELISAs and Western blots. In direct ELISAs and Western blots, no cross-reactivity with recombinant human (rh) Cadherin-8, -11, -13, -17, rhE-Cadherin, rhP-Cadherin, rhR-Cadherin, or rhVR-Cadherin is observed.
使用方法	Flow Cytometry: 0.25-1 µg/10⁶cells
来源	The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
产品组分

性能
供应商	R&D Systems
Entrez Gene IDs	1010 (Human)
免疫原	S. frugiperda insect ovarian cell line Sf 21-derived recombinant human Cadherin-12 Met1-Pro609 Accession # P55289
生物活性	Human
标记	Alexa Fluor 700
背景	The cadherin superfamily is a large family of membrane-associated glycoproteins that engage in homotypic, calcium-dependent, cell-cell adhesion events. The superfamily can be divided into at least four subfamilies based on its member’s extracellular (EC) regions and cytoplasmic domains (1, 2). These include classical cadherins, desmosomal cadherins, protocadherins, and cadherin-like molecules that contain a variable number of EC and transmembrane (TM) domains (1). Cadherin‑12, also known as brain-cadherin and N-cadherin 2, is a 150 kDa classical cadherin. Classical family molecules are modular in their extracellular region, mediating calcium-dependent cell-cell adhesion through their five EC Ca⁺⁺-binding repeats (2). Cadherin-12 can be further identified as a type II classical cadherin, due to the absence of a His-Ala-Val motif in its most N-terminal cadherin repeat (3). Human Cadherin-12 is synthesized as a 794 amino acid (aa) type I transmembrane preproprotein that contains a 23 aa signal peptide, a 31 aa prosequence, a 555 aa extracellular region, a 28 aa transmembrane segment, and a 157 aa cytoplasmic domain (4, 5). The five EC cadherin domains are approximately 110 aa in length and generate two beta -sheets that are oriented like bread in a sandwich. Human Cadherin-12 EC region is 96% aa identical to mouse Cadherin-12 EC region. Cadherin-12 is expressed specifically in CNS neurons. The bulk of its expression is postnatal, and it is proposed to be involved in synaptogenesis (4). As a classic cadherin, Cadherin-12 will form homodimers and promote intercellular adhesion with itself and, possibly, cadherins-8 and -14 (6).
运输条件	Blue Ice
存放说明	4℃
参考文献	Koch, A.W. et al. (2004) Cell. Mol. Life Sci. 61:1884. Angst, B.D. et al. (2001) J. Cell Sci. 114:629. Gessner, R. and R. Tauber (2000) Ann. N.Y. Acad. Sci. 915:136. Selig, S. et al. (1997) Proc. Natl. Acad. Sci. USA 94:2398. Tanihara, H. et al. (1994) Cell Adhes. Commun. 2:15. Shimoyama, Y. et al. (2000) Biochem. J. 349:159.