| 货号 | IC4257U-100UG |
| 别名 | HTF; TREB5; X-box binding protein 1; X-box-binding protein 1; XBP1; XBP-1; XBP2; XBP2Tax-responsive element-binding protein 5 | 全称 | X-box Binding Protein 1 |
| 应用 | Intracellular Staining by Flow Cytometry |
| 目标/特异性 | Detects human XBP1 (S Isoform) (XBP1S) in direct ELISAs. This segment is found only in the XBP1S (spliced) variant. Does not detect XBP1U (unspliced). |
| 使用方法 | Intracellular Staining by Flow Cytometry: 0.25-1 µg/106cells |
| 来源 | The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below. |
| 产品组分 |
| 供应商 | R&D Systems |
| Entrez Gene IDs | 7494 (Human); 22433 (Mouse); 289754 (Rat) |
| 免疫原 | E. coli-derived recombinant human XBP1S Ser188-Leu287 Accession # NP_001073007 |
| 生物活性 | Human |
| 标记 | Alexa Fluor 350 |
| 背景 | X-box binding protein 1 (XBP1; also tax-responsive element-binding protein 5 (TREB5) is a ubiquitously expressed member of the bZIP family of proteins. The spliced form of XBP1 (XBP1S) is a 376 amino acid (aa), 55 kDa transcription factor essential for the unfolded protein response. XBP1S is formed during endoplasmic reticulum stress by IRE-1-mediated splicing that creates a 210 aa substitution for XBP1 aa 161-261. XBP1S contains a basic DNA binding motif (aa 72-94) and a leucine-zipper domain (aa 98-126). Within the region used as an immunogen, human XBP1S shares 96% aa sequence identity with mouse XBP1S. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 参考文献 |
|