Human Phospho-GSK-3 beta (S9) Fluorescein MAb (Clone 609739) (100 TESTS)【科瑞奥博】

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Human Phospho-GSK-3 beta (S9) Fluorescein MAb (Clone 609739) (100 TESTS)

货号： IC1590F 基本售价： 3529.5 元规格： 100 Tests

产品信息

概述
货号	IC1590F
别名	EC 2.7.11; EC 2.7.11.26; glycogen synthase kinase 3 beta; glycogen synthase kinase-3 beta; GSK-3 beta; GSK3B; GSK3beta isoform
全称	Glycogen Synthase Kinase 3 beta
反应种属	Human
应用	Intracellular Staining by Flow Cytometry(10 µL/10⁶cells)
目标/特异性	Detects human GSK-3 beta when phosphorylated at S9.
使用方法	Intracellular Staining by Flow Cytometry: 10 µL/10⁶cells
来源	The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
产品组分

性能
供应商	R&D Systems
Entrez Gene IDs	2932 (Human); 56637 (Mouse); 84027 (Rat)
应用文献
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions. Convergence of the Mammalian Target of Rapamycin Complex 1- and Glycogen Synthase Kinase 3-{beta}-Signaling Pathways Regulates the Innate Inflammatory Response. Authors: Wang H, Brown J, Gu Z, Garcia CA, Liang R, Alard P, Beurel E, Jope RS, Greenway T, Martin M J. Immunol., 2011;186(9):5217-26. Species: Human Sample Type: Whole Cells Application: Flow The role of glycogen synthase kinase 3 in regulating IFN-beta-mediated IL-10 production. Authors: Wang H, Brown J, Garcia CA, Tang Y, Benakanakere MR, Greenway T, Alard P, Kinane DF, Martin M J. Immunol., 2011;186(2):675-84. Species: Human Sample Type: Whole Cells Application: Flow NKG2D receptor regulates human effector T-cell cytokine production. Authors: Barber A, Sentman CL Blood, 2011;117(24):6571-81. Species: Human Sample Type: Whole Cells Application: Flow
纯化方式	Protein A or G purified from hybridoma culture supernatant
免疫原	Phosphopeptide containing the human GSK-3 beta S9 site
生物活性	Human
标记	Fluorescein
背景	Glycogen Synthase Kinase-3 (GSK-3) is a serine/threonine kinase initially identified as an inhibitor of Glycogen Synthase. Two isoforms (GSK-3 alpha and GSK-3 beta ) share 85% amino acid identity. GSK-3 beta, inhibited by phosphorylation at S9 by Akt, is involved in energy metabolism, body pattern formation, and neuronal cell development.
运输条件	Blue Ice
存放说明	4℃
参考文献	Apoptosis Intracellular Kinases Cell Structure and Signaling Molecules Chemokine Receptor Intracellular Signaling Common gamma Chain Receptor Family EMT Induction Hedgehog Family ICC / IHC Images: GSK-3 beta IL-17 Family Intracellular Kinases in the Akt Pathway Intracellular Signaling Molecules in Angiogenesis Notch Pathway Wnt Intracellular Signaling

参考图片

Detection of GSK‑3 beta in HeLa Human Cell Line by Flow Cytometry. HeLa human cervical epithelial carcinoma cell line untreated (open histogram) or treated with PMA (filled histogram) was stained with Mouse Anti-Human Phospho-GSK‑3 beta (S9) Fluorescein‑conjugated Monoclonal Antibody (Catalog # IC1590F) or isotype control antibody (Catalog # IC002F, data not shown). To facilitate intracellular staining, cells were fixed with Flow Cytometry Fixation Buffer (Catalog # FC004) and permeabilized with Flow Cytometry Permeabilization/Wash Buffer I (Catalog # FC005). View our protocol for Staining Intracellular Molecules.