Human CD161 Alexa Fluor 488 MAb (Clone 702228) (100 TESTS)
货号:
FAB7448G 基本售价:
3529.5 元 规格:
100 Tests
产品信息
概述货号 | FAB7448G |
别名 | CD161 antigen; CD161; CLEC5B; CLEC5BC-type lectin domain family 5 member B; HNKR-P1a; killer cell lectin-like receptor subfamily B member 1; killer cell lectin-like receptor subfamily B, member 1; KLRB1; Ly59; Natural killer cell surface protein P1A; NKR; NKRP1; NKR-P1; NKRP1A; NKR-P1AMGC138614; NKRP1ANKR |
反应种属 | Human |
应用 | Flow Cytometry(5 µL/106cells)
|
目标/特异性 | Detects human CD161 in direct ELISAs. |
使用方法 | Flow Cytometry: 5 µL/106cells
|
来源 | The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below. |
产品组分 | |
性能供应商 | R&D Systems |
Entrez Gene IDs | 3820 (Human) |
纯化方式 | Protein A or G purified from hybridoma culture supernatant |
免疫原 | BaF3 mouse pro-B cell line transfected with human CD161 Accession # Q12918 |
生物活性 | Human |
标记 | Alexa Fluor 488 |
背景 | CD161, also known as NKR-P1A and KLRB1, is a 40 kDa type II transmembrane glycoprotein that contains one C-type lectin domain in its extracellular region. CD161 is expressed as a disulfide-linked dimer on the surface of Th17 cells and NK cells as well as on subsets of CD1-restricted T cells, intestinal NT cells, peripheral memory T cells, monocytes, and dendritic cells. It binds to OCIL/CLEC2d, leading to an inhibition of NK cell-mediated cytotoxicity and IFN-g secretion. Alternatively, CD161 can enhance TCR activation to CD1d ligation. CD161+ cell populations are depleted in ulcerative colitis, Grave’s disease, and AIDS, although CD161+ T cells are activated during asthmatic attacks. Additional related proteins are expressed in mouse but not human: the inhibitory NKR‑P1B and D, and the stimulatory NKR‑P1A, C, and F. Human CD161 shares 47% aa sequence identity with mouse and rat NKR-P1A. |
运输条件 | Blue Ice |
存放说明 | 4℃ |
参考文献 | - C-type Lectin Family
- gamma delta T Cells
- Group 1 ILCs
- Group 2 ILCs
- Isolation, Culture, and Identification of Natural Killer Cells
- LTi Cells
- Natural Killer T (NKT) Cells
- NCR+ILC3
- Th17 Cells
|
参考图片Detection of CD161 in Human PBMCs byFlow Cytometry. Human peripheral blood mononuclearcells (PBMCs) were stained with Mouse Anti-Human CD161Alexa Fluor® 488‑conjugated Monoclonal Antibody(Catalog # FAB7448G) and Mouse Anti-Human CD4 APC‑conjugatedMonoclonal Antibody (Catalog # FAB3791A).View our protocol for StainingMembrane-associated Proteins. |