Human CD21 Fluorescein MAb (Clone 544408) (100 TESTS)【科瑞奥博】

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Human CD21 Fluorescein MAb (Clone 544408) (100 TESTS)

货号： FAB4909F 基本售价： 3529.5 元规格： 100 Tests

产品信息

概述
货号	FAB4909F
别名	C3DR; C3DRSLEB9; CD21 antigen; CD21; Complement C3d receptor; complement component (3d/Epstein Barr virus) receptor 2; complement receptor type 2; CR2; EBV receptor; Epstein-Barr virus receptor
反应种属	Human
应用	Flow Cytometry(10 µL/10⁶cells)
目标/特异性	Detects human CD21 in direct ELISAs and Western blots.
使用方法	Flow Cytometry: 10 µL/10⁶cells
来源	The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
产品组分

性能
供应商	R&D Systems
Entrez Gene IDs	1380 (Human); 12902 (Mouse); 289395 (Rat)
应用文献
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions. Natural IgM is required for suppression of inflammatory arthritis by apoptotic cells. Authors: Notley CA, Brown MA, Wright GP, Ehrenstein MR J. Immunol., 2011;186(8):4967-72. Species: Mouse Sample Type: Whole Cells Application: Flow
纯化方式	Protein A or G purified from hybridoma culture supernatant
免疫原	Chinese hamster ovary cell line CHO-derived recombinant human CD21 Ile21-Arg971 Accession # P20023
生物活性	Human
标记	Fluorescein
背景	CD21 (also called EBV receptor or CR2) is a 145 kDa member of the RCA (receptors of complement activation) family of proteins. It is expressed on T cells, B cells, and follicular dendritic cells. On the B cell surface, it combines with the BCR and CD19 to form a B cell activating complex. Mature human CD21 is 1013 amino acids (aa) in length. It is a type I transmembrane (TM) protein that contains a 951 aa extracellular domain (ECD) (aa 21-971) and a short 34 aa cytoplasmic tail. The ECD exhibits fifteen 60 aa SUSHI repeats. Soluble CD21 can be generated by cleavage near the TM domain. One potential splice variant shows a deletion of aa 847‑908, while another shows an insertion of 59 aa after Lys659. The ECD of human CD21 shares 71% aa identity with mouse CD21 ECD.
运输条件	Blue Ice
存放说明	4℃
参考文献	B Cell Activation B Cell Development and Differentiation B Cell Markers Complement Pathway Co-stimulatory Molecules Associated with Tfh Cells Myeloid-derived Suppressor Cells (MDSC)

参考图片

Detection of CD21 in Human PBMCs by Flow Cytometry. Human peripheral blood mononuclear cells (PBMCs) were stained with Mouse Anti-Human CD19 APC‑conjugated Monoclonal Antibody (Catalog # FAB4867A) and either (A) Mouse Anti-Human CD21 Fluorescein‑conjugated Monoclonal Antibody (Catalog # FAB4909F) or (B) Mouse IgG₁ Fluorescein Isotype Control (Catalog # IC002F). View our protocol for Staining Membrane-associated Proteins.