Human Integrin beta 7 Fluorescein MAb (Clone 473207) (100 TESTS)【科瑞奥博】

产品中心

当前位置：首页>产品中心

Human Integrin beta 7 Fluorescein MAb (Clone 473207) (100 TESTS)

货号： FAB4669F 基本售价： 3529.5 元规格： 100 Tests

产品信息

概述
货号	FAB4669F
别名	Gut homing receptor beta subunit; integrin beta 7 subunit; integrin beta-7; integrin, beta 7; ITGB7
反应种属	Human
应用	Flow Cytometry(10 µL/10⁶cells)
目标/特异性	Detects human Integrin beta 7 in direct ELISAs and Western blots. In Western blots, no cross-reactivity with recombinant human Integrin beta 1, beta 2, beta 3, beta 4, beta 5, beta 6, beta 8, recombinant mouse Integrin beta 4, or beta 7 is observed.
使用方法	Flow Cytometry: 10 µL/10⁶cells
来源	The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
产品组分

性能
供应商	R&D Systems
Entrez Gene IDs	3695 (Human); 16421 (Mouse); 25713 (Rat)
应用文献
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions. Decreases in colonic and systemic inflammation in chronic HIV infection after IL-7 administration. Authors: Sereti I, Estes J, Thompson W, Morcock D, Fischl M, Croughs T, Beq S, Lafaye de Micheaux S, Yao M, Ober A, Wilson E, Natarajan V, Imamichi H, Boulassel M, Lederman M, Routy J PLoS Pathog, 2014;10(1):e1003890. Species: Human Sample Type: Whole Cells Application: Flow
纯化方式	Protein A or G purified from hybridoma culture supernatant
免疫原	Chinese hamster ovary cell line CHO-derived recombinant human Integrin beta 7 long isoform Glu20-His723 Accession # P26010
生物活性	Human
标记	Fluorescein
背景	Human Integrin beta 7 (also Integrin beta P and M290 IEL Ag) is a 120 kDa member of the Integrin beta chain family of molecules. It is a type I transmembrane glycoprotein that contains a 704 amino acid (aa) extracellular domain (ECD) (aa 20‑723) and a 52 aa cytoplasmic tail. The ECD contains one von Willebrand factor A domain (aa 150‑389) and four cysteine‑rich EGF‑like repeats. One splice variant exists that shows a deletion of aa 501‑648. Integrin beta 7 forms a nondisulfide linked heterodimer with alpha 4 and alpha E integrins. alpha 4 beta 7 binds fibronectin, VCAM-1 and MADCAM1, while alpha E beta 7 binds E-cadherin. The ECD of human beta 7 is 87% aa identical to the ECD of mouse beta 7.
运输条件	Blue Ice
存放说明	4℃
参考文献	Acute Lymphoblastic Leukemia Adhesion Molecules Adhesive Interactions in Allergy and Asthma HGF/SF Activation of Integrins Integrin Ligands at a Glance (J. Cell. Sci.) Integrin Subunit Interactions Integrins and Associated Molecules

参考图片

Detection of Integrin beta 7 in PBMCs Lymphocytes by Flow Cytometry. Human peripheral blood lymphocytes were stained with Mouse Anti-Human Integrin beta 7 Fluorescein‑conjugated Monoclonal Antibody (Catalog # FAB4669F, filled histogram) or isotype control antibody (Catalog # IC002F, open histogram). View our protocol for Staining Membrane-associated Proteins.