Human CCR5 Fluorescein MAb (Clone 45531) (100 TESTS)【科瑞奥博】

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Human CCR5 Fluorescein MAb (Clone 45531) (100 TESTS)

货号： FAB182F-100 基本售价： 3390.7 元规格： 100 Tests

产品信息

概述
货号	FAB182F-100
别名	C-C CKR-5; C-C motif chemokine receptor 5 A159A; CCCKR5; CC-CKR-5FLJ78003; CCR5; CCR-5; CD195 antigen; CD195; chemokine (C-C motif) receptor 5; chemokine receptor CCR5; chemr13; CKR5; CKR-5; HIV-1 fusion coreceptor; IDDM22CMKBR5C-C chemokine receptor type 5
反应种属	Human
应用	Flow Cytometry(10 µL/10⁶cells)
目标/特异性	Detects human CCR5.
使用方法	Flow Cytometry: 10 µL/10⁶cells
来源	The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
产品组分

性能
供应商	R&D Systems
Entrez Gene IDs	1234 (Human); 12774 (Mouse); 117029 (Rat); 484789 (Canine); 493769 (Feline)
应用文献
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions. Involvement of the second extracellular loop and transmembrane residues of CCR5 in inhibitor binding and HIV-1 fusion: insights into the mechanism of allosteric inhibition. Authors: Maeda K, Das D, Yin PD, Tsuchiya K, Ogata-Aoki H, Nakata H, Norman RB, Hackney LA, Takaoka Y, Mitsuya H J. Mol. Biol., 2008;381(4):956-74. Species: Human Sample Type: Whole Cells Application: Flow NF-kappaB modulates sensitivity to apoptosis, proinflammatory and migratory potential in short- versus long-term cultured human gammadelta lymphocytes. Authors: Ferrarini M, Delfanti F, Gianolini M, Rizzi C, Alfano M, Lazzarin A, Biswas P J. Immunol., 2008;181(9):5857-64. Species: Human Sample Type: Whole Cells Application: Flow Inhibition of HIV-1 infection by viral chemokine U83A via high-affinity CCR5 interactions that block human chemokine-induced leukocyte chemotaxis and receptor internalization. Authors: Catusse J, Parry CM, Dewin DR, Gompels UA Blood, 2007;109(9):3633-9. Species: Human Sample Type: Whole Cells Application: Flow Phenotypic and functional analysis of T cells homing into the CSF of subjects with inflammatory diseases of the CNS. Authors: Giunti D, Borsellino G, Benelli R, Marchese M, Capello E, Valle MT, Pedemonte E, Noonan D, Albini A, Bernardi G, Mancardi GL, Battistini L, Uccelli A J. Leukoc. Biol., 2003;73(5):584-90. Species: Human Sample Type: Whole Cells Application: Flow
纯化方式	Protein A or G purified from ascites
免疫原	NS0 mouse myeloma cell line transfected with human CCR5 Met1-Leu352 Accession # P51681
生物活性	Human
标记	Fluorescein
背景	CCR5 is a G protein-linked seven transmembrane domain chemokine receptor. CCR5 serves as a receptor for several chemokines including MIP-1 alpha, MIP-1 beta, MCP-2, and RANTES. It also functions as a coreceptor for macrophage tropic HIV-1 infection.
运输条件	Blue Ice
存放说明	4℃
参考文献	CC Chemokines and Receptors Chemokine Receptors Chemokines and Receptors in Angiogenesis Common Macrophage Markers Cytokine Upregulation of HIV Coreceptors gamma delta T Cells Human CD Marker Products Infectious Diseases Monocyte Markers Multiple Myeloma Neuroinflammation Receptors in the Jak/STAT Pathway Regulatory T Cells (Tregs) T Cell Migration/Adhesion T. gondii: A Therapeutic Agent for HIV-1? Th1 Cells

参考图片

Detection of CCR5 in NS0 Mouse Cell Line Transfected with Human CCR5 by Flow Cytometry. NS0 mouse myeloma cell line transfected with human CCR5 was stained with Mouse Anti-Human CCR5 Fluorescein‑conjugated Monoclonal Antibody (Catalog # FAB182F, filled histogram) or isotype control antibody (Catalog # IC0041F, open histogram). View our protocol for Staining Membrane-associated Proteins.