Human Claudin-4 Fluorescein MAb (Clone 382321) (100 TESTS)【科瑞奥博】

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Human Claudin-4 Fluorescein MAb (Clone 382321) (100 TESTS)

货号： FAB4219F 基本售价： 3390.7 元规格： 100 Tests

产品信息

概述
货号	FAB4219F
别名	claudin 4; CLDN4; Clostridium perfringens enterotoxin receptor 1; Clostridium perfringens enterotoxin receptor; CPE-R; CPE-RCPETR; CPE-receptor; CPETR1; hCPE-R; WBSCR8; WBSCR8CPERCPETR1claudin-4; Williams-Beuren syndrome chromosomal region 8 protein
反应种属	Human
应用	Flow Cytometry(10 µL/10⁶cells)
目标/特异性	Detects human Claudin‑4. Stains human Claudin-4 transfectants but not irrelevant transfectants. Recognizes an epitope in the first extracellular loop (aa Met29-Arg81).
使用方法	Flow Cytometry: 10 µL/10⁶cells
来源	The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
产品组分

性能
供应商	R&D Systems
Entrez Gene IDs	1364 (Human); 12740 (Mouse); 304407 (Rat)
应用文献
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions. Claudin 4-targeted nanographene phototherapy using a Clostridium perfringens enterotoxin peptide-photosensitizer conjugate Authors: G Shim, MG Kim, H Jin, J Kim, YK Oh Acta Pharmacol. Sin., 2017;38(6):954-962. Species: Human Sample Type: Whole Cells Application: Flow
纯化方式	Protein A or G purified from hybridoma culture supernatant
免疫原	NS0 mouse myeloma cell line transfected with human Claudin-4 Met1-Val209 Accession # NP_001296
生物活性	Human
标记	Fluorescein
背景	Claudin-4 is a multipass membrane protein in the claudin family of tight junction proteins. Claudin-4 is a 209 amino acid molecule with four transmembrane segments. It is preferentially expressed in intestinal mucosa epithelium and is involved in epithelial tissue development. It is also up-regulated in several carcinomas. Phosphorylation of Claudin-4 regulates paracellular epithelial permeability. Human Claudin-4 shares 83% aa sequence identity with mouse and rat Claudin-4.
运输条件	Blue Ice
存放说明	4℃
参考文献	Cell to Cell Adhesion Disassembly During EMT Claudins Epithelial Cell Markers and Intracellular Molecules Epithelial Cell Polarity Protein/Peptide Hormones and Regulators Steroid Hormones and Bioactive Lipids Surface Ectodermal Cells

参考图片

Detection of Claudin‑4 in PC‑3 Human Cell Line by Flow Cytometry. PC‑3 human prostate cancer cell line was stained with Mouse Anti-Human Claudin‑4 Fluorescein‑conjugated Monoclonal Antibody (Catalog # FAB4219F, filled histogram) or isotype control antibody (Catalog # IC003F, open histogram). View our protocol for Staining Membrane-associated Proteins.