| 货号 | FAB6287F |
| 别名 | CD85 antigen-like family member G; CD85g antigen; CD85g; ILT7; ILT-7; ILT7MGC129598; Immunoglobulin-like transcript 7; leukocyte immunoglobulin-like receptor subfamily A member 4; leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 4; leukocyte immunoglobulin-like receptor, subfamily A (without TM domain), member4; MGC129597 | 全称 | Leukocyte Immunoglobulin-like Receptor, Subfamily A (with TM domain), Member 4 |
| 反应种属 | Human |
| 应用 | Flow Cytometry(10 µL/106cells) |
| 目标/特异性 | Detects human ILT7/CD85g in direct ELISAs. In direct ELISAs, no cross-reactivitywith recombinant human (rh) LILRA5, rhILT2, 3, 4, 5, or 6 is observed. |
| 使用方法 | Flow Cytometry: 10 µL/106cells |
| 来源 | The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below. |
| 产品组分 |
| 供应商 | R&D Systems |
| Entrez Gene IDs | 23547 (Human) |
| 应用文献 | |
| R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions. Buffering capacity and size of siRNA polyplexes influence cytokine levels. | |
| 纯化方式 | Protein A or G purified from hybridoma culture supernatant |
| 免疫原 | Mouse myeloma cell line NS0-derived recombinant human ILT7/CD85g Glu24-Asn446 Accession # P59901 |
| 生物活性 | Human |
| 标记 | Fluorescein |
| 背景 | ILT7, also known as LILRA4 and CD85g, is a 499 amino acid (aa) type I transmembrane glycoprotein that contains four Ig-like domains in its extracellular region. ILT7 is selectively expressed on plasmacytoid dendritic cells (pDC). It binds to BST2/CD317 on bone marrow stromal cells and associates with the gamma subunit of Fc epsilon RI. This receptor complex transmits signals that inhibit the TLR-induced production of type I interferon. The ILT7-mediated interactions between pDC and tumor cells similarly inhibit the production of proinflammatory cytokines and contribute to reduced anti-tumor immune responses. Alternate splicing of human ILT7 generates an isoform that lacks the N-terminal 43 aa of the extracellular domain. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 参考文献 |
|
Detection of ILT7/CD85g in Human Blood Monocytes by Flow Cytometry. Human peripheral blood monocytes were stained with Mouse Anti-Human ILT7/CD85g Fluorescein‑conjugated Monoclonal Antibody (Catalog # FAB6287F) and Anti-Human DLEC APC-conjugated Antibody. Quadrant markers were set based on control antibody staining (Catalog # IC003F). View our protocol for Staining Membrane-associated Proteins. |
