MicroRNA-134 Contributes to Glucose-Induced Endothelial Cell Dysfunction and This Effect Can Be Reversed by Far-Infrared Irradiation.
Authors: Wang H, Su S, Wang Y, Chang S, Liao K, Lo H, Chiu Y, Hsieh T, Huang T, Lin C, Cheng S, Cheng C
PLoS ONE, 2016;11(1):e0147067.
Species: Human
Sample Type: Whole Cells
Application: Flow
Dysregulation of ossification related microRNAs in circulating osteogenic progenitor cells obtained from patients with aortic stenosis
Authors: K Takahashi, M Satoh, Y Takahashi, T Osaki, T Nasu, M Tamada, H Okabayashi, M Nakamura, Y Morino
Clin Sci, 2016;0(0):.
Species: Human
Sample Type: Whole Cells
Application: Flow
Cloche is a bHLH-PAS transcription factor that drives haemato-vascular specification
Nature, 2016;535(7611):294-8.
Species: Human
Sample Type: Whole Cells
Application: Flow
Glucose transporter 1-positive endothelial cells in infantile hemangioma exhibit features of facultative stem cells.
Authors: Huang L, Nakayama H, Klagsbrun M, Mulliken J, Bischoff J
Stem Cells, 2015;33(1):133-45.
Species: Human
Sample Type: Whole Cells
Application: Flow
Generation of articular chondrocytes from human pluripotent stem cells.
Authors: Craft A, Rockel J, Nartiss Y, Kandel R, Alman B, Keller G
Nat Biotechnol, 2015;33(6):638-45.
Species: Human
Sample Type: Whole Cells
Application: Flow
The inflammation, vascular repair and injury responses to exercise in fit males with and without Type 1 diabetes: an observational study.
Authors: West D, Campbell M, Gonzalez J, Walker M, Stevenson E, Ahmed F, Wijaya S, Shaw J, Weaver J
Cardiovasc Diabetol, 2015;14(0):71.
Species: Human
Sample Type: Other
Application: Flow
Vascular niche promotes hematopoietic multipotent progenitor formation from pluripotent stem cells.
Authors: Gori J, Butler J, Chan Y, Chandrasekaran D, Poulos M, Ginsberg M, Nolan D, Elemento O, Wood B, Adair J, Rafii S, Kiem H
J Clin Invest, 2015;125(3):1243-54.
Species: Macaca nemistrina
Sample Type: Whole Cells
Application: Flow
Efficiency of statin treatment on EPC recruitment depends on baseline EPC titer and does not improve angiographic outcome in coronary artery disease patients treated with the Genous stent.
Authors: den Dekker W, Houtgraaf J, Rowland S, Ligtenberg E, de Boer S, de Jong R, de Winter R, den Heijer P, Zijlstra F, Serruys P, Cheng C, Duckers H
Cell Transplant, 2014;23(12):1525-35.
Species: Human
Sample Type: whole cells
Application: Flow
Circulating angiogenic cell dysfunction in patients with hereditary hemorrhagic telangiectasia.
Authors: Zucco L, Zhang Q, Kuliszewski M, Kandic I, Faughnan M, Stewart D, Kutryk M
PLoS ONE, 2014;9(2):e89927.
Species: Human
Sample Type: Whole Cells
Application: Flow
Hypoxia-controlled EphA3 marks a human endometrium-derived multipotent mesenchymal stromal cell that supports vascular growth.
Authors: To C, Farnsworth R, Vail M, Chheang C, Gargett C, Murone C, Llerena C, Major A, Scott A, Janes P, Lackmann M
PLoS ONE, 2014;9(11):e112106.
Species: Human
Sample Type: Whole Cells
Application: Flow
The relationship between endothelial progenitor cell populations and epicardial and microvascular coronary disease-a cellular, angiographic and physiologic study.
Authors: Chan, Kim H, Simpson, Philippa, Yong, Andy S, Dunn, Louise L, Chawantanpipat, Chirapan, Hsu, Chijen, Yu, Young, Keech, Anthony, Celermajer, David S, Ng, Martin K
PLoS ONE, 2014;9(4):e93980.
Species: Human
Sample Type: Whole Cells
Application: Flow
Laminin promotes vascular network formation in 3D in vitro collagen scaffolds by regulating VEGF uptake.
Authors: Stamati K, Priestley J, Mudera V, Cheema U
Exp Cell Res, 2014;327(1):68-77.
Species: Human
Sample Type: Whole Cells
Application: Flow
The dipeptidyl peptidase-4 inhibitor saxagliptin improves function of circulating pro-angiogenic cells from type 2 diabetic patients.
Authors: Poncina N, Albiero M, Menegazzo L, Cappellari R, Avogaro A, Fadini G
Cardiovasc Diabetol, 2014;13(0):92.
Species: Human
Sample Type: Whole Cells
Application: Flow
The synergistic effect of everolimus and chloroquine on endothelial cell number reduction is paralleled by increased apoptosis and reduced autophagy occurrence.
Authors: Grimaldi A, Balestrieri M, DOnofrio N, Di Domenico G, Nocera C, Lamberti M, Tonini G, Zoccoli A, Santini D, Caraglia M, Pantano F
PLoS ONE, 2013;8(11):e79658.
Species: Human
Sample Type: Whole Cells
Application: Flow
CXCR4 positive and angiogenic monocytes in myocardial infarction.
Thromb Haemost, 2013;109(2):255-62.
Species: Human
Sample Type: Whole Blood
Application: Flow
Functional and molecular characterization of ex vivo cultured epiretinal membrane cells from human proliferative diabetic retinopathy.
Authors: Vereb Z, Lumi X, Andjelic S, Globocnik-Petrovic M, Urbancic M, Hawlina M, Facsko A, Petrovski G
Biomed Res Int, 2013;2013(0):492376.
Species: Human
Sample Type: whole cells
Application: Flow
Circulating endothelial progenitor cells decrease in infants with bronchopulmonary dysplasia and increase after inhaled nitric oxide.
Authors: Qi, Yuanyuan, Jiang, Qian, Chen, Chao, Cao, Yun, Qian, Liling
PLoS ONE, 2013;8(11):e79060.
Species: Human
Sample Type: Plasma
Application: Flow
Cultivation and characterization of cornea limbal epithelial stem cells on lens capsule in animal material-free medium.
Authors: Albert R, Vereb Z, Csomos K, Moe M, Johnsen E, Olstad O, Nicolaissen B, Rajnavolgyi E, Fesus L, Berta A, Petrovski G
PLoS ONE, 2012;7(10):e47187.
Species: Human
Sample Type: Whole Cells
Application: Flow
Human haemato-endothelial precursors: cord blood CD34+ cells produce haemogenic endothelium.
Authors: Pelosi E, Castelli G, Martin-Padura I, Bordoni V, Santoro S, Conigliaro A, Cerio A, De Santis Puzzonia M, Marighetti P, Biffoni M, Alonzi T, Amicone L, Alcalay M, Bertolini F, Testa U, Tripodi M
PLoS ONE, 2012;7(12):e51109.
Species: Human
Sample Type: Whole Cells
Application: Flow
GMP-compliant isolation and large-scale expansion of bone marrow-derived MSC.
Authors: Fekete N, Rojewski M, Furst D, Kreja L, Ignatius A, Dausend J, Schrezenmeier H
PLoS ONE, 2012;7(8):e43255.
Species: Human
Sample Type: Whole Cells
Application: Flow
Successful In Vitro Expansion and Differentiation of Cord Blood Derived CD34+ Cells into Early Endothelial Progenitor Cells Reveals Highly Differential Gene Expression.
Authors: Ahrens I, Domeij H, Topcic D
PLoS ONE, 2011;6(8):e23210.
Species: Human
Sample Type: Whole Cells
Application: Flow
Comparison of endothelial progenitor cell function in type 2 diabetes with good and poor glycemic control.
Authors: Churdchomjan, Worachat, Kheolamai, Pakpoom, Manochantr, Sirikul, Tapanadechopone, Pirath, Tantrawatpan, Chairat, U-Pratya, Yaowalak, Issaragrisil, Surapol
BMC Endocr Disord, 2010;10(0):5.
Species: Human
Sample Type: whole cells
Application: Flow
Multiple receptor tyrosine kinases regulate HIF-1alpha and HIF-2alpha in normoxia and hypoxia in neuroblastoma: implications for antiangiogenic mechanisms of multikinase inhibitors.
Authors: Nilsson MB, Zage PE, Zeng L, Xu L, Cascone T, Wu HK, Saigal B, Zweidler-McKay PA, Heymach JV
Oncogene, 2010;29(20):2938-49.
Species: Human
Sample Type: Whole Cells
Application: Flow
Neuropilin-1 regulates platelet-derived growth factor receptor signalling in mesenchymal stem cells.
Authors: Ball SG, Bayley C, Shuttleworth CA, Kielty CM
Biochem. J., 2010;427(1):29-40.
Species: Human
Sample Type: Whole Cells
Application: Flow
Distraction osteogenesis induces endothelial progenitor cell mobilization without inflammatory response in man.
Authors: Lee DY, Cho TJ, Lee HR, Park MS, Yoo WJ, Chung CY, Choi IH
Bone, 2010;46(3):673-9.
Species: Human
Sample Type: Whole Cells
Application: Flow
Oligo-guanosine nucleotide induces neuropilin-1 internalization in endothelial cells and inhibits angiogenesis.
Authors: Narazaki M, Segarra M, Hou X, Tanaka T, Li X, Tosato G
Blood, 2010;116(16):3099-107.
Species: Human
Sample Type: Whole Cells
Application: Flow
VEGFR2 is selectively expressed by FOXP3high CD4+ Treg.
Authors: Suzuki H, Onishi H, Wada J, Yamasaki A, Tanaka H, Nakano K, Morisaki T, Katano M
Eur. J. Immunol., 2010;40(1):197-203.
Species: Human
Sample Type: Whole Cells
Application: Flow
Colocalization of the VEGF-R2 and the common IL-3/GM-CSF receptor beta chain to lipid rafts leads to enhanced p38 activation.
Authors: Saulle E, Riccioni R, Coppola S, Parolini I, Diverio D, Riti V, Mariani G, Laufer S, Sargiacomo M, Testa U
Br. J. Haematol., 2009;145(3):399-411.
Species: Human
Sample Type: Whole Cells
Application: Flow
Microtubule-targeted drugs inhibit VEGF receptor-2 expression by both transcriptional and post-transcriptional mechanisms.
Authors: Meissner M, Pinter A, Michailidou D, Hrgovic I, Kaprolat N, Stein M, Holtmeier W, Kaufmann R, Gille J
J. Invest. Dermatol., 2008;128(8):2084-91.
Species: Human
Sample Type: Whole Cells
Application: Flow
Sulfated polysaccharides identified as inducers of neuropilin-1 internalization and functional inhibition of VEGF165 and semaphorin3A.
Authors: Narazaki M, Segarra M, Tosato G
Blood, 2008;111(8):4126-36.
Species: Human
Sample Type: Whole Cells
Application: Flow
Late outgrowth endothelial progenitor cells in patients with age-related macular degeneration.
Authors: Thill M, Strunnikova NV, Berna MJ, Gordiyenko N, Schmid K, Cousins SW, Thompson DJ, Csaky KG
Invest. Ophthalmol. Vis. Sci., 2008;49(6):2696-708.
Species: Human
Sample Type: Whole Cells
Application: Flow
Highly efficient and feeder-free production of subculturable vascular endothelial cells from primate embryonic stem cells.
Authors: Saeki K, Yogiashi Y, Nakahara M, Nakamura N, Matsuyama S, Koyanagi A, Yagita H, Koyanagi M, Kondo Y, Yuo A
J. Cell. Physiol., 2008;217(1):261-80.
Species: Primate – Macaca fascicularis (Cynomolgus/Crab-eating Monkey)
Sample Type: Whole Cells
Application: Flow
Alternative splicing of vasohibin-1 generates an inhibitor of endothelial cell proliferation, migration, and capillary tube formation.
Authors: Kern J, Bauer M, Rychli K, Wojta J, Ritsch A, Gastl G, Gunsilius E, Untergasser G
Arterioscler. Thromb. Vasc. Biol., 2008;28(3):478-84.
Species: Human
Sample Type: Whole Cells
Application: Flow
Tumor necrosis factor-alpha and endothelial cells modulate Notch signaling in the bone marrow microenvironment during inflammation.
Authors: Fernandez L, Rodriguez S, Huang H, Chora A, Fernandes J, Mumaw C, Cruz E, Pollok K, Cristina F, Price JE, Ferkowicz MJ, Scadden DT, Clauss M, Cardoso AA, Carlesso N
Exp. Hematol., 2008;36(5):545-558.
Species: Human
Sample Type: Whole Cells
Application: Flow
Human cardiovascular progenitor cells develop from a KDR+ embryonic-stem-cell-derived population.
Authors: Yang L, Soonpaa MH, Adler ED, Roepke TK, Kattman SJ, Kennedy M, Henckaerts E, Bonham K, Abbott GW, Linden RM, Field LJ, Keller GM
Nature, 2008;453(7194):524-8.
Species: Human
Sample Type: Whole Cells
Application: Flow
Endothelial progenitor cell levels in obese men with the metabolic syndrome and the effect of simvastatin monotherapy vs. simvastatin/ezetimibe combination therapy.
Authors: Westerweel PE, Visseren FL, Hajer GR, Olijhoek JK, Hoefer IE, de Bree P, Rafii S, Doevendans PA, Verhaar MC
Eur. Heart J., 2008;29(22):2808-17.
Species: Human
Sample Type: Whole Cells
Application: Flow
Short-term BMP-4 treatment initiates mesoderm induction in human embryonic stem cells.
Authors: Zhang P, Li J, Tan Z, Wang C, Liu T, Chen L, Yong J, Jiang W, Sun X, DU L, Ding M, Deng H
Blood, 2007;111(4):1933-41.
Species: Human
Sample Type: Whole Cells
Application: Flow
Type I interferon as a novel risk factor for endothelial progenitor cell depletion and endothelial dysfunction in systemic lupus erythematosus.
Authors: Lee PY, Li Y, Richards HB, Chan FS, Zhuang H, Narain S, Butfiloski EJ, Sobel ES, Reeves WH, Segal MS
Arthritis Rheum., 2007;56(11):3759-69.
Species: Human
Sample Type: Whole Cells
Application: Flow
Increased circulating endothelial progenitor cells in septic patients: correlation with survival.
Authors: Rafat N, Hanusch C, Brinkkoetter PT, Schulte J, Brade J, Zijlstra JG, van der Woude FJ, van Ackern K, Yard BA, Beck GCh
Crit. Care Med., 2007;35(7):1677-84.
Species: Human
Sample Type: Whole Cells
Application: Flow
Notch alters VEGF responsiveness in human and murine endothelial cells by direct regulation of VEGFR-3 expression.
Authors: Shawber CJ, Funahashi Y, Francisco E, Vorontchikhina M, Kitamura Y, Stowell SA, Borisenko V, Feirt N, Podgrabinska S, Shiraishi K, Chawengsaksophak K, Rossant J, Accili D, Skobe M, Kitajewski J
J. Clin. Invest., 2007;117(11):3369-82.
Species: Human
Sample Type: Whole Cells
Application: Flow
Blood-based biomarkers of SU11248 activity and clinical outcome in patients with metastatic imatinib-resistant gastrointestinal stromal tumor.
Authors: Norden-Zfoni A, Desai J, Manola J, Beaudry P, Force J, Maki R, Folkman J, Bello C, Baum C, DePrimo SE, Shalinsky DR, Demetri GD, Heymach JV
Clin. Cancer Res., 2007;13(9):2643-50.
Species: Human
Sample Type: Whole Cells
Application: Flow
VEGFR2 expressing circulating (progenitor) cell populations in volunteers and cancer patients.
Authors: Vroling L, Yuana Y, Schuurhuis GJ, van Hinsbergh VW, Gundy C, de Haas R, van Cruijsen H, Boven E, Hoekman K, Broxterman HJ
Thromb. Haemost., 2007;98(2):440-50.
Species: Human
Sample Type: Whole Blood
Application: Flow
Vascular endothelial growth factor can signal through platelet-derived growth factor receptors.
Authors: Ball SG, Shuttleworth CA, Kielty CM
J. Cell Biol., 2007;177(3):489-500.
Species: Human
Sample Type: Whole Cells
Application: Flow
Ligand-induced internalization selects use of common receptor neuropilin-1 by VEGF165 and semaphorin3A.
Authors: Narazaki M, Tosato G
Blood, 2006;107(10):3892-901.
Species: Human
Sample Type: Whole Cells
Application: Flow
Enalapril increases ischemia-induced endothelial progenitor cell mobilization through manipulation of the CD26 system.
Authors: Wang CH, Verma S, Hsieh IC, Chen YJ, Kuo LT, Yang NI, Wang SY, Wu MY, Hsu CM, Cheng CW, Cherng WJ
J. Mol. Cell. Cardiol., 2006;41(1):34-43.
Species: Mouse
Sample Type: Whole Cells
Application: Flow
Isolation of an adult blood-derived progenitor cell population capable of differentiation into angiogenic, myocardial and neural lineages.
Authors: Porat Y, Porozov S, Belkin D, Shimoni D, Fisher Y, Belleli A, Czeiger D, Silverman WF, Belkin M, Battler A, Fulga V, Savion N
Br. J. Haematol., 2006;135(5):703-14.
Species: Human
Sample Type: Whole Cells
Application: Flow
Expansion of human SCID-repopulating cells under hypoxic conditions.
Authors: Danet GH, Pan Y, Luongo JL, Bonnet DA, Simon MC
J. Clin. Invest., 2003;112(1):126-35.
Species: Human
Sample Type: Whole Cells
Application: Flow
Structural and functional studies of the endothelial activation antigen endothelial leucocyte adhesion molecule-1 using a panel of monoclonal antibodies.
Authors: Pigott R, Needham LA, Edwards RM
J. Immunol., 1991;147(1):130-5.
Species: Human
Sample Type: Whole Cells
Application: Flow

VEGF R2 (KDR/Flk-1), VEGF R1 (Flt-1) and VEGF R3 (Flt-4) belong to the class III subfamily of receptor tyrosine kinases (RTKs). All three receptors contain seven immunoglobulin-like repeats in their extracellular domains and kinase insert domains in their intracellular regions. The expression of VEGF R1, 2, and 3 is almost exclusively restricted to the endothelial cells. These receptors are likely to play essential roles in vasculogenesis and angiogenesis. Mature VEGF R2 is composed of a 745 aa extracellular domain, a 25 aa transmembrane domain and a 567 aa cytoplasmic domain. In contrast to VEGF R1 which binds both PlGF and VEGF with high affinity, VEGF R2 binds VEGF but not PlGF with high affinity. The recombinant soluble VEGF R2/Fc chimera binds VEGF with high affinity and is a potent VEGF antagonist.

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