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Human CCR6 Phycoerythrin MAb (Clone 53103) (25 TESTS)

货号: FAB195P-025 基本售价: 1407.8 元 规格: 25 Tests

产品信息

概述
货号FAB195P-025
简介Clone 53103 was used by HLDA to establish CD designation
别名BN-1; CC-CKR-6; CCR6; CCR-6; CD196 antigen; CD196; chemokine (C-C motif) receptor 6; CKR-L3G-protein coupled receptor 29; CKRL3LARC receptor; CMKBR6STRL22; DRY6; GPR29; GPR29C-C CKR-6; GPR-CY4; GPRCY4DRY-6; lymphocyte, 22; STRL22
反应种属Human
应用Flow Cytometry(10 µL/106cells)
目标/特异性Detects human CCR6. Stains human CCR6 transfectants but not the parental cell line in flow cytometry. Does not cross-react with transfectants expressing human CCR1, CCR2, CCR3, CCR4, CCR5, CCR7, CXCR1, CXCR2, CXCR3, CXCR4, or STRL33.
使用方法Flow Cytometry: 10 µL/106cells
来源The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
产品组分
性能
供应商R&D Systems
Entrez Gene IDs1235 (Human); 12458 (Mouse); 308163 (Rat)
应用文献
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

Co-culture of human bronchial fibroblasts and CD4+ T cells increases Th17 cytokine signature.
Authors: Loubaki L, Hadj-Salem I, Fakhfakh R, Jacques E, Plante S, Boisvert M, Aoudjit F, Chakir J
PLoS ONE, 2013;8(12):e81983.
Species: Human
Sample Type: whole cells
Application: Flow
Human MAIT cells are xenobiotic-resistant, tissue-targeted, CD161hi IL-17-secreting T cells.
Authors: Dusseaux M, Martin E, Serriari N, Peguillet I, Premel V, Louis D, Milder M, Le Bourhis L, Soudais C, Treiner E, Lantz O
Blood, 2011;117(4):1250-9.
Species: Human
Sample Type: Whole Cells
Application: Flow
Thymoquinone inhibits the CXCL12-induced chemotaxis of multiple myeloma cells and increases their susceptibility to Fas-mediated apoptosis.
Authors: Badr G, Lefevre EA, Mohany M
PLoS ONE, 2011;6(9):e23741.
Species: Human
Sample Type: Whole Cells
Application: Flow
AIDS progression is associated with the emergence of IL-17-producing cells early after simian immunodeficiency virus infection.
Authors: Campillo-Gimenez L, Cumont MC, Fay M, Kared H, Monceaux V, Diop O, Muller-Trutwin M, Hurtrel B, Levy Y, Zaunders J, Dy M, Leite-de-Moraes MC, Elbim C, Estaquier J
J. Immunol., 2010;184(2):984-92.
Species: Primate - Macaca mulatta (Rhesus monkey)
Sample Type: Whole Cells
Application: Flow
Distinct roles for CCR4 and CXCR3 in the recruitment and positioning of regulatory T cells in the inflamed human liver.
Authors: Oo YH, Weston CJ, Lalor PF, Curbishley SM, Withers DR, Reynolds GM, Shetty S, Harki J, Shaw JC, Eksteen B, Hubscher SG, Walker LS, Adams DH
J. Immunol., 2010;184(6):2886-98.
Species: Human
Sample Type: Whole Cells
Application: Flow
Evidence for HIV-associated B cell exhaustion in a dysfunctional memory B cell compartment in HIV-infected viremic individuals.
Authors: Moir S, Ho J, Malaspina A, Wang W, DiPoto AC, OShea MA, Roby G, Kottilil S, Arthos J, Proschan MA, Chun TW, Fauci AS
J. Exp. Med., 2008;205(8):1797-805.
Species: Human
Sample Type: Whole Cells
Application: Flow
Chronically inflamed human tissues are infiltrated by highly differentiated Th17 lymphocytes.
Authors: Pene J, Chevalier S, Preisser L, Venereau E, Guilleux MH, Ghannam S, Moles JP, Danger Y, Ravon E, Lesaux S, Yssel H, Gascan H
J. Immunol., 2008;180(0):7423.
Species: Human
Sample Type: Whole Cells
Application: Flow
Chemokine production and chemokine receptor expression by human glioma cells: role of CXCL10 in tumour cell proliferation.
Authors: Maru SV, Holloway KA, Flynn G, Lancashire CL, Loughlin AJ, Male DK, Romero IA
J. Neuroimmunol., 2008;199(1):35-45.
Species: Human
Sample Type: Whole Cells
Application: Flow
CD43, but not P-selectin glycoprotein ligand-1, functions as an E-selectin counter-receptor in human pre-B-cell leukemia NALL-1.
Authors: Nonomura C, Kikuchi J, Kiyokawa N, Ozaki H, Mitsunaga K, Ando H, Kanamori A, Kannagi R, Fujimoto J, Muroi K, Furukawa Y, Nakamura M
Cancer Res., 2008;68(3):790-9.
Species: Human
Sample Type: Whole Cells
Application: Flow
Lactoferrin, a major defense protein of innate immunity, is a novel maturation factor for human dendritic cells.
Authors: Spadaro M, Caorsi C, Ceruti P, Varadhachary A, Forni G, Pericle F, Giovarelli M
FASEB J., 2008;22(8):2747-57.
Species: Human
Sample Type: Whole Cells
Application: Flow
Down-modulation of CXCR3 surface expression and function in CD8+ T cells from cutaneous T cell lymphoma patients.
Authors: Winter D, Moser J, Kriehuber E, Wiesner C, Knobler R, Trautinger F, Bombosi P, Stingl G, Petzelbauer P, Rot A, Maurer D
J. Immunol., 2007;179(6):4272-82.
Species: Human
Sample Type: Whole Cells
Application: Flow
Expression and role of CCR6/CCL20 chemokine axis in pulmonary sarcoidosis.
Authors: Facco M, Baesso I, Miorin M, Bortoli M, Cabrelle A, Boscaro E, Gurrieri C, Trentin L, Zambello R, Calabrese F, Cassatella MA, Semenzato G, Agostini C
J. Leukoc. Biol., 2007;82(4):946-55.
Species: Human
Sample Type: Whole Cells
Application: Flow
Chemokine receptor expression in EBV-associated lymphoproliferation in hu/SCID mice: implications for CXCL12/CXCR4 axis in lymphoma generation.
Authors: Piovan E, Tosello V, Indraccolo S, Cabrelle A, Baesso I, Trentin L, Zamarchi R, Tamamura H, Fujii N, Semenzato G, Chieco-Bianchi L, Amadori A
Blood, 2005;105(3):931-9.
Species: Human
Sample Type: Whole Cells
Application: Flow
Recapitulation of B cell differentiation in the central nervous system of patients with multiple sclerosis.
Authors: Casazza S, Zappia E, Pistorio A, Gambini C
Proc. Natl. Acad. Sci. U.S.A., 2004;101(30):11064-9.
Species: Human
Sample Type: Whole Cells
Application: Flow
Phenotypic and functional analysis of T cells homing into the CSF of subjects with inflammatory diseases of the CNS.
Authors: Giunti D, Borsellino G, Benelli R, Marchese M, Capello E, Valle MT, Pedemonte E, Noonan D, Albini A, Bernardi G, Mancardi GL, Battistini L, Uccelli A
J. Leukoc. Biol., 2003;73(5):584-90.
Species: Human
Sample Type: Whole Cells
Application: Flow
Chemokine receptor expression on human eosinophils from peripheral blood and bronchoalveolar lavage fluid after segmental antigen challenge.
Authors: Liu LY, Jarjour NN, Busse WW, Kelly EA
J. Allergy Clin. Immunol., 2003;112(3):556-62.
Species: Human
Sample Type: BALF
Application: Flow

纯化方式Protein A or G purified from ascites
免疫原NS0 mouse myeloma cell line transfected with human CCR6
Met1-Met374
Accession # P51684
生物活性Human
标记Phycoerythrin
背景

CCR6 is a seven transmembrane-spanning G protein-coupled receptor that binds the chemokine MIP-3 alpha and mediates the chemoattraction of B and T lymphocytes.

运输条件Blue Ice
存放说明4℃
参考文献
  • B Cell Chemotaxis, Migration, and Adhesion
  • CC Chemokines and Receptors
  • Chemokine Receptors
  • Chemokines and Receptors in Allergy and Asthma
  • Chemokines and Receptors in Angiogenesis
  • Dendritic Cell Adhesion and Migration
  • gamma delta T Cells
  • Human CD Marker Products
  • LTi Cells
  • Monocyte Markers
  • Natural Killer T (NKT) Cells
  • Regulatory T Cells (Tregs)
  • T Cell Migration/Adhesion
  • Th17 Cells
  • Th22 Cells
参考图片
Detection of CCR6 in Human PBMCs by Flow Cytometry. Human peripheral blood mononuclear cells (PBMCs) were stained with Mouse Anti-Human CD19 APC‑conjugated Monoclonal Antibody (Catalog # FAB4867A) and either (A) Mouse Anti-Human CCR6 PE‑conjugated Monoclonal Antibody (Catalog # FAB195P) or (B) Mouse IgG2B Phycoerythrin Isotype Control (Catalog # IC0041P). View our protocol for Staining Membrane-associated Proteins.