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Human CCR7 Phycoerythrin MAb (Clone 150503) (25 TESTS)

货号: FAB197P-025 基本售价: 1407.8 元 规格: 25 Tests

产品信息

概述
货号FAB197P-025
简介Clone 150503 was used by HLDA to establish CD designation
别名BLR2C-C chemokine receptor type 7; C-C CKR-7; CC-CKR-7; CCR7; CCR-7; CD197 antigen; CD197; CDw197CC chemokine receptor 7; chemokine (C-C motif) receptor 7; CMKBR7chemokine (C-C) receptor 7; EBI1EBV-induced G protein-coupled receptor 1; EBV-induced G-protein coupled receptor 1; Epstein-Barr virus induced gene 1; Epstein-Barr virus induced G-protein coupled receptor; Epstein-Barr virus-induced G-protein coupled receptor 1; EVI1; lymphocyte-specific G protein-coupled peptide receptor; MIP-3 beta receptor
反应种属Human
应用Flow Cytometry
目标/特异性The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
使用方法Flow Cytometry: 10 µL/106cells
来源Monoclonal Mouse IgG2A Clone # 150503
产品组分
性能
供应商R&D Systems
Entrez Gene IDs1236 (Human); 12775 (Mouse); 287673 (Rat)
应用文献
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

Pertussis circulation has increased T-cell immunity during childhood more than a second acellular booster vaccination in Dutch children 9 years of age.
Authors: Schure R, de Rond L, Ozturk K, Hendrikx L, Sanders E, Berbers G, Buisman A
PLoS ONE, 2102;7(7):e41928.
Species: Human
Sample Type: Whole Cells
Application: Flow
Effective Cytotoxic T Lymphocyte Targeting of Persistent HIV-1 during Antiretroviral Therapy Requires Priming of Naive CD8+ T Cells
Authors: Kellie N Smith
MBio, 2016;7(3):.
Species: Human
Sample Type: Whole Cells
Application: Flow
Characterization of CD8+ T cell differentiation following SIVDeltanef vaccination by transcription factor expression profiling.
Authors: Billingsley J, Rajakumar P, Connole M, Salisch N, Adnan S, Kuzmichev Y, Hong H, Reeves R, Kang H, Li W, Li Q, Haase A, Johnson R
PLoS Pathog, 2015;11(3):e1004740.
Species: Primate - Macaca mulatta (Rhesus monkey)
Sample Type: Whole Cells
Application: Flow
Functional capacities of human IgM memory B cells in early inflammatory responses and secondary germinal center reactions.
Authors: Seifert M, Przekopowitz M, Taudien S, Lollies A, Ronge V, Drees B, Lindemann M, Hillen U, Engler H, Singer B, Kuppers R
Proc Natl Acad Sci U S A, 2015;112(6):E546-55.
Species: Human
Sample Type: Whole Cells
Application: Flow
Human regulatory T cells lack the cyclophosphamide-extruding transporter ABCB1 and are more susceptible to cyclophosphamide-induced apoptosis.
Authors: Dimeloe S, Frick C, Fischer M, Gubser P, Razik L, Bantug G, Ravon M, Langenkamp A, Hess C
Eur J Immunol, 2014;44(12):3614-20.
Species: Human
Sample Type: Whole Cells
Application: Flow
A thymic stromal lymphopoietin-responsive dendritic cell subset mediates allergic responses in the upper airway mucosa.
Authors: Melum G, Farkas L, Scheel C, Van Dieren B, Gran E, Liu Y, Johansen F, Jahnsen F, Baekkevold E
J Allergy Clin Immunol, 2014;134(3):613-621.e7.
Species: Human
Sample Type: Whole Cells
Application: Flow
Manipulating the expression of chemokine receptors enhances delivery and activity of cytokine-induced killer cells.
Authors: Zou Y, Li F, Hou W, Sampath P, Zhang Y, Thorne S
Br J Cancer, 2014;110(8):1992-9.
Species: Human
Sample Type: Whole Cells
Application: Flow
The road to memory: an early rest for the long journey.
Authors: Ho, Liam Poc, Yit, Pui San, Ng, Lee Hui, Linn, Yeh Chin, Zhao, Yi, Sun, Li, Ling, Khoon Li, Chai Koh, Mickey B, Monica Shih, Meng-Chu, Li, Shang, Wang, Xue Ying, Tien, Sim Leng, Goh, Yeow Tee
J Immunol, 2013;191(11):5603-14.
Species: Human
Sample Type: cells
Application: Flow
Biomarkers on melanoma patient T cells associated with ipilimumab treatment.
Authors: Wang W, Yu D, Sarnaik A, Yu B, Hall M, Morelli D, Zhang Y, Zhao X, Weber J
J Transl Med, 2012;10(0):146.
Species: Human
Sample Type: whole cells
Application: Flow
Thymoquinone inhibits the CXCL12-induced chemotaxis of multiple myeloma cells and increases their susceptibility to Fas-mediated apoptosis.
Authors: Badr G, Lefevre EA, Mohany M
PLoS ONE, 2011;6(9):e23741.
Species: Human
Sample Type: Whole Cells
Application: Flow
Distinct roles for CCR4 and CXCR3 in the recruitment and positioning of regulatory T cells in the inflamed human liver.
Authors: Oo YH, Weston CJ, Lalor PF, Curbishley SM, Withers DR, Reynolds GM, Shetty S, Harki J, Shaw JC, Eksteen B, Hubscher SG, Walker LS, Adams DH
J. Immunol., 2010;184(6):2886-98.
Species: Human
Sample Type: Whole Cells
Application: Flow
CD56highCD16-CD62L- NK cells accumulate in allergic contact dermatitis and contribute to the expression of allergic responses.
Authors: Carbone T, Nasorri F, Pennino D
J. Immunol., 2010;184(2):1102-10.
Species: Human
Sample Type: Whole Cells
Application: Flow
Chemokine responsiveness of CD4+ CD25+ regulatory and CD4+ CD25- T cells from atopic and nonatopic donors.
Authors: Ahern D, Lloyd CM, Robinson DS
Allergy, 2009;64(8):1121-9.
Species: Human
Sample Type: Whole Cells
Application: Flow
Homeostatic chemokines CCL19 and CCL21 promote inflammation in human immunodeficiency virus-infected patients with ongoing viral replication.
Authors: Damas JK, Landro L, Fevang B, Heggelund L, Tjonnfjord GE, Floisand Y, Halvorsen B, Froland SS, Aukrust P
Clin. Exp. Immunol., 2009;157(3):400-7.
Species: Human
Sample Type: Whole Cells
Application: Flow
Production of interleukin 22 but not interleukin 17 by a subset of human skin-homing memory T cells.
Authors: Duhen T, Geiger R, Jarrossay D, Lanzavecchia A, Sallusto F
Nat. Immunol., 2009;10(8):857-63.
Species: Human
Sample Type: Whole Cells
Application: Flow
Lactoferrin, a major defense protein of innate immunity, is a novel maturation factor for human dendritic cells.
Authors: Spadaro M, Caorsi C, Ceruti P, Varadhachary A, Forni G, Pericle F, Giovarelli M
FASEB J., 2008;22(8):2747-57.
Species: Human
Sample Type: Whole Cells
Application: Flow
Evidence for HIV-associated B cell exhaustion in a dysfunctional memory B cell compartment in HIV-infected viremic individuals.
Authors: Moir S, Ho J, Malaspina A, Wang W, DiPoto AC, OShea MA, Roby G, Kottilil S, Arthos J, Proschan MA, Chun TW, Fauci AS
J. Exp. Med., 2008;205(8):1797-805.
Species: Human
Sample Type: Whole Cells
Application: Flow
CD43, but not P-selectin glycoprotein ligand-1, functions as an E-selectin counter-receptor in human pre-B-cell leukemia NALL-1.
Authors: Nonomura C, Kikuchi J, Kiyokawa N, Ozaki H, Mitsunaga K, Ando H, Kanamori A, Kannagi R, Fujimoto J, Muroi K, Furukawa Y, Nakamura M
Cancer Res., 2008;68(3):790-9.
Species: Human
Sample Type: Whole Cells
Application: Flow
BAFF enhances chemotaxis of primary human B cells: a particular synergy between BAFF and CXCL13 on memory B cells.
Authors: Badr G, Borhis G, Lefevre EA, Chaoul N, Deshayes F, Dessirier V, Lapree G, Tsapis A, Richard Y
Blood, 2008;111(5):2744-54.
Species: Human
Sample Type: Whole Cells
Application: Flow
IL-12-impaired and IL-12-secreting dendritic cells produce IL-23 upon CD154 restimulation.
Authors: Jasny E, Eisenblatter M, Matz-Rensing K, Tenner-Racz K, Tenbusch M, Schrod A, Stahl-Hennig C, Moos V, Schneider T, Racz P, Uberla K, Kaup FJ, Ignatius R
J. Immunol., 2008;180(10):6629-39.
Species: Primate - Macaca mulatta (Rhesus monkey)
Sample Type: Whole Cells
Application: Flow
Expression of CXC and CC type of chemokines and its receptors in tuberculous and non-tuberculous effusions.
Authors: Pokkali S, Das SD, R L
Cytokine, 2008;41(3):307-14.
Species: Human
Sample Type: Whole Cells
Application: Flow
Dissociation of its opposing immunologic effects is critical for the optimization of antitumor CD8+ T-cell responses induced by interleukin 21.
Authors: Ansen S, Butler MO, Berezovskaya A, Murray AP, Stevenson K, Nadler LM, Hirano N
Clin. Cancer Res., 2008;14(19):6125-36.
Species: Human
Sample Type: Whole Cells
Application: Flow
Ability of herpes simplex virus vectors to boost immune responses to DNA vectors and to protect against challenge by simian immunodeficiency virus.
Authors: Kaur A, Sanford HB, Garry D, Lang S, Klumpp SA, Watanabe D, Bronson RT, Lifson JD, Rosati M, Pavlakis GN, Felber BK, Knipe DM, Desrosiers RC
Virology, 2007;357(2):199-214.
Species: Primate - Macaca mulatta (Rhesus monkey)
Sample Type: Whole Cells
Application: Flow
Interleukins 1beta and 6 but not transforming growth factor-beta are essential for the differentiation of interleukin 17-producing human T helper cells.
Authors: Acosta-Rodriguez EV, Napolitani G, Lanzavecchia A, Sallusto F
Nat. Immunol., 2007;8(9):942-9.
Species: Human
Sample Type: Whole Cells
Application: Flow
Trapping and apoptosis of novel subsets of memory T lymphocytes expressing CCR6 in the spleen of HIV-infected patients.
Authors: Lecureuil C, Combadiere B, Mazoyer E, Bonduelle O, Samri A, Autran B, Debre P, Combadiere C
Blood, 2007;109(9):3649-57.
Species: Human
Sample Type: Whole Cells
Application: Flow
The apoptotic-cell receptor CR3, but not alphavbeta5, is a regulator of human dendritic-cell immunostimulatory function.
Authors: Skoberne M, Somersan S, Almodovar W, Truong T, Petrova K, Henson PM, Bhardwaj N
Blood, 2006;108(3):947-55.
Species: Human
Sample Type: Whole Cells
Application: Flow
Epithelial inflammation is associated with CCL28 production and the recruitment of regulatory T cells expressing CCR10.
Authors: Eksteen B, Miles A, Curbishley SM, Tselepis C, Grant AJ, Walker LS, Adams DH
J. Immunol., 2006;177(1):593-603.
Species: Human
Sample Type: Whole Cells
Application: Flow
Chemokine receptors in head and neck cancer: association with metastatic spread and regulation during chemotherapy.
Authors: Muller A, Sonkoly E, Eulert C, Gerber PA, Kubitza R, Schirlau K, Franken-Kunkel P, Poremba C, Snyderman C, Klotz LO, Ruzicka T, Bier H, Zlotnik A, Whiteside TL, Homey B, Hoffmann TK
Int. J. Cancer, 2006;118(9):2147-57.
Species: Human
Sample Type: Whole Cells
Application: Flow
In vitro-expanded human CD4(+)CD25(+) T-regulatory cells can markedly inhibit allogeneic dendritic cell-stimulated MLR cultures.
Authors: Godfrey WR, Ge YG, Spoden DJ, Levine BL, June CH, Blazar BR, Porter SB
Blood, 2004;104(2):453-61.
Species: Human
Sample Type: Whole Cells
Application: Flow
Recapitulation of B cell differentiation in the central nervous system of patients with multiple sclerosis.
Authors: Casazza S, Zappia E, Pistorio A, Gambini C
Proc. Natl. Acad. Sci. U.S.A., 2004;101(30):11064-9.
Species: Human
Sample Type: Whole Cells
Application: Flow
Human cerebrospinal fluid central memory CD4+ T cells: evidence for trafficking through choroid plexus and meninges via P-selectin.
Authors: Kivisakk P, Mahad DJ, Callahan MK, Trebst C, Tucky B, Wei T, Wu L, Baekkevold ES, Lassmann H, Staugaitis SM, Campbell JJ, Ransohoff RM
Proc. Natl. Acad. Sci. U.S.A., 2003;100(14):8389-94.
Species: Human
Sample Type: Whole Cells
Application: Flow
Chemokine receptor expression on human eosinophils from peripheral blood and bronchoalveolar lavage fluid after segmental antigen challenge.
Authors: Liu LY, Jarjour NN, Busse WW, Kelly EA
J. Allergy Clin. Immunol., 2003;112(3):556-62.
Species: Human
Sample Type: BALF
Application: Flow

纯化方式Protein A or G purified from hybridoma culture supernatant
免疫原Human CCR7 transfectants
Met1-Pro378
Accession # AAA58615
生物活性Human
标记Phycoerythrin
背景

CCR7 is a 7 transmembrane G protein coupled chemokine receptor. CCR7 is expressed on T cells and mature dendritic cells and transduces chemotactic signals in response to CCL19 and CCL21. Human CCR7 shares 87% amino acid sequence identity with mouse CCR7.

运输条件Blue Ice
存放说明4℃
参考文献
  • Cancer Biomarkers
  • CC Chemokines and Receptors
  • Chemokine Receptors
  • Chemokines and Receptors in Angiogenesis
  • Chemokines and Receptors in Tfh Cell Differentiation and Function
  • Dendritic Cell Adhesion and Migration
  • Human CD Marker Products
  • ICC / IHC Images: CCR7
  • Regulatory T Cells (Tregs)
  • T Cell Migration/Adhesion
  • Technical Notes: CCR7
参考图片
Detection of CCR7 in Human Blood Lymphocytes by Flow Cytometry. Human peripheral blood lymphocytes were stained with Mouse Anti-Human CD4 APC‑conjugated Monoclonal Antibody (Catalog # FAB3791A) and either (A) Mouse Anti-Human CCR7 PE‑conjugated Monoclonal Antibody (Catalog # FAB197P) or (B) Mouse IgG2A Phycoerythrin Isotype Control (Catalog # IC003P). View our protocol for Staining Membrane-associated Proteins.
Detection of CCR7 in HEK293 Human Cell Line Transfected with Human CCR7 and eGFP by Flow Cytometry. The specificity of Mouse Anti-Human CCR7 Clone 150503 was demonstrated by its ability to react with (A) HEK293 human embryonic kidney cell line transfected with human CCR7 and not react with (B) irrelevant HEK293 transfectants. Antibody binding was monitored using Phycoerythrin-conjugated Anti-Mouse IgG Secondary Antibody (Catalog # F0102B).