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Human CCR7 Fluorescein MAb (Clone 150503) (25 TESTS)

货号: FAB197F-025 基本售价: 1259.1 元 规格: 25 Tests

产品信息

概述
货号FAB197F-025
简介Clone 150503 was used by HLDA to establish CD designation
别名BLR2C-C chemokine receptor type 7; C-C CKR-7; CC-CKR-7; CCR7; CCR-7; CD197 antigen; CD197; CDw197CC chemokine receptor 7; chemokine (C-C motif) receptor 7; CMKBR7chemokine (C-C) receptor 7; EBI1EBV-induced G protein-coupled receptor 1; EBV-induced G-protein coupled receptor 1; Epstein-Barr virus induced gene 1; Epstein-Barr virus induced G-protein coupled receptor; Epstein-Barr virus-induced G-protein coupled receptor 1; EVI1; lymphocyte-specific G protein-coupled peptide receptor; MIP-3 beta receptor
反应种属Human
应用Flow Cytometry
目标/特异性The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
使用方法Flow Cytometry: 10 µL/106cells
来源Monoclonal Mouse IgG2A Clone # 150503
产品组分
性能
供应商R&D Systems
Entrez Gene IDs1236 (Human); 12775 (Mouse); 287673 (Rat)
应用文献
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

Effective Cytotoxic T Lymphocyte Targeting of Persistent HIV-1 during Antiretroviral Therapy Requires Priming of Naive CD8+ T Cells
Authors: Kellie N Smith
MBio, 2016;7(3):.
Species: Human
Sample Type: Whole Cells
Application: Flow
Envelope residue 375 substitutions in simian-human immunodeficiency viruses enhance CD4 binding and replication in rhesus macaques
Authors: Hui Li
Proc Natl Acad Sci USA, 2016;113(24):E3413-22.
Species: Human
Sample Type: Whole Cells
Application: Flow
Glycolysis determines dichotomous regulation of T cell subsets in hypoxia
Authors: Yang Xu
J Clin Invest, 2016;0(0):.
Species: Human
Sample Type: Whole Cells
Application: Flow
Human Non-neutralizing HIV-1 Envelope Monoclonal Antibodies Limit the Number of Founder Viruses during SHIV Mucosal Infection in Rhesus Macaques.
Authors: Santra S, Tomaras G, Warrier R, Nicely N, Liao H, Pollara J, Liu P, Alam S, Zhang R, Cocklin S, Shen X, Duffy R, Xia S, Schutte R, Pemble Iv C, Dennison S, Li H, Chao A, Vidnovic K, Evans A, Klein K, Kumar A, Robinson J, Landucci G, Forthal D, Montefiori D, Kaewkungwal J, Nitayaphan S, Pitisuttithum P, Rerks-Ngarm S, Robb M, Michael N, Kim J, Soderberg K, Giorgi E, Blair L, Korber B, Moog C, Shattock R, Letvin N, Schmitz J, Moody M, Gao F, Ferrari G, Shaw G, Haynes B
PLoS Pathog, 2015;11(8):e1005042.
Species: Human
Sample Type: Whole Cells
Application: Flow
Tetramer enrichment reveals the presence of phenotypically diverse hepatitis C virus-specific CD8+ T cells in chronic infection.
Authors: Nitschke K, Flecken T, Schmidt J, Gostick E, Marget M, Neumann-Haefelin C, Blum H, Price D, Thimme R
J Virol, 2015;89(1):25-34.
Species: Human
Sample Type: Whole Cells
Application: Flow
Evaluating Human T-Cell Therapy of Cytomegalovirus Organ Disease in HLA-Transgenic Mice.
Authors: Thomas S, Klobuch S, Podlech J, Plachter B, Hoffmann P, Renzaho A, Theobald M, Reddehase M, Herr W, Lemmermann N
PLoS Pathog, 2015;11(7):e1005049.
Species: Human
Sample Type: Whole Cells
Application: Flow
Cytomegalovirus-Induced Expression of CD244 after Liver Transplantation Is Associated with CD8+ T Cell Hyporesponsiveness to Alloantigen.
Authors: de Mare-Bredemeijer E, Shi X, Mancham S, van Gent R, van der Heide-Mulder M, de Boer R, Heemskerk M, de Jonge J, van der Laan L, Metselaar H, Kwekkeboom J
J Immunol, 2015;195(4):1838-48.
Species: Human
Sample Type: Whole Cells
Application: Flow
Severe acute respiratory syndrome-coronavirus infection in aged nonhuman primates is associated with modulated pulmonary and systemic immune responses.
Authors: Clay C, Donart N, Fomukong N, Knight J, Overheim K, Tipper J, Van Westrienen J, Hahn F, Harrod K
Immun Ageing, 2014;11(1):4.
Species: Primate - Cholrocebus pygerythrus (African green monkey)
Sample Type: tissue lysates
Application: Flow
Concurrent interaction of DCs with CD4(+) and CD8(+) T cells improves secondary CTL expansion: It takes three to tango.
Authors: Hoyer S, Prommersberger S, Pfeiffer I, Schuler-Thurner B, Schuler G, Dorrie J, Schaft N
Eur J Immunol, 2014;44(12):3543-59.
Species: Human
Sample Type: Whole Cells
Application: Flow
Cytomegalovirus drives Vdelta2neg gammadelta T cell inflation in many healthy virus carriers with increasing age.
Authors: Alejenef A, Pachnio A, Halawi M, Christmas S, Moss P, Khan N
Clin Exp Immunol, 2014;176(3):418-28.
Species: Human
Sample Type: Whole Cells
Application: Flow
IL-18-based combinatorial adjuvants promote the intranodal production of CCL19 by NK cells and dendritic cells of cancer patients.
Authors: Wong J, Muthuswamy R, Bartlett D, Kalinski P
Oncoimmunology, 2013;2(9):e26245.
Species: Human
Sample Type: Whole Cells
Application: Flow
Bone marrow T cells from the femur are similar to iliac crest derived cells in old age and represent a useful tool for studying the aged immune system.
Authors: Pritz T, Landgraf-Rauf K, Herndler-Brandstetter D, Rauf R, Lair J, Gassner R, Weinberger B, Krismer M, Grubeck-Loebenstein B
Immun Ageing, 2013;10(1):17.
Species: Human
Sample Type: Whole Cells
Application: Flow
CCR5 is a receptor for Staphylococcus aureus leukotoxin ED.
Authors: Alonzo, Francis, Kozhaya, Lina, Rawlings, Stephen, Reyes-Robles, Tamara, DuMont, Ashley L, Myszka, David G, Landau, Nathanie, Unutmaz, Derya, Torres, Victor J
Nature, 2013;493(7430):51-5.
Species: Human
Sample Type: whole cells

Targeting of macrophage galactose-type C-type lectin (MGL) induces DC signaling and activation.
Authors: Napoletano C, Zizzari IG, Rughetti A, Rahimi H, Irimura T, Clausen H, Wandall HH, Belleudi F, Bellati F, Pierelli L, Frati L, Nuti M
Eur. J. Immunol., 2012;42(4):936-45.
Species: Human
Sample Type: Whole Cells
Application: Flow
The CD46-Jagged1 interaction is critical for human TH1 immunity.
Authors: Le Friec G, Sheppard D, Whiteman P, Karsten C, Shamoun S, Laing A, Bugeon L, Dallman M, Melchionna T, Chillakuri C, Smith R, Drouet C, Couzi L, Fremeaux-Bacchi V, Kohl J, Waddington S, McDonnell J, Baker A, Handford P, Lea S, Kemper C
Nat Immunol, 2012;13(12):1213-21.
Species: Human
Sample Type: whole cells
Application: Flow
Biomarkers on melanoma patient T cells associated with ipilimumab treatment.
Authors: Wang W, Yu D, Sarnaik A, Yu B, Hall M, Morelli D, Zhang Y, Zhao X, Weber J
J Transl Med, 2012;10(0):146.
Species: Human
Sample Type: whole cells
Application: Flow
CCR2+CCR5+ T Cells Produce Matrix Metalloproteinase-9 and Osteopontin in the Pathogenesis of Multiple Sclerosis.
Authors: Sato W, Tomita A, Ichikawa D, Lin Y, Kishida H, Miyake S, Ogawa M, Okamoto T, Murata M, Kuroiwa Y, Aranami T, Yamamura T
J Immunol, 2012;189(10):5057-65.
Species: Human
Sample Type: Whole Cells
Application: Flow
Identification of human NK17/NK1 cells.
Authors: Pandya AD, Al-Jaderi Z, Hoglund RA, Holmoy T, Harbo HF, Norgauer J, Maghazachi AA
PLoS ONE, 2011;6(10):e26780.
Species: Human
Sample Type: Whole Cells
Application: Flow
Primary B-cell deficiencies reveal a link between human IL-17-producing CD4 T-cell homeostasis and B-cell differentiation.
Authors: Barbosa RR, Silva SP, Silva SL, Melo AC, Pedro E, Barbosa MP, Pereira-Santos MC, Victorino RM, Sousa AE
PLoS ONE, 2011;6(8):e22848.
Species: Human
Sample Type: Whole Cells
Application: Flow
Hypoxia modulates the gene expression profile of immunoregulatory receptors in human mature dendritic cells: identification of TREM-1 as a novel hypoxic marker in vitro and in vivo.
Authors: Bosco MC, Pierobon D, Blengio F, Raggi F, Vanni C, Gattorno M, Eva A, Novelli F, Cappello P, Giovarelli M, Varesio L
Blood, 2011;117(9):2625-39.
Species: Human
Sample Type: Whole Cells
Application: Flow
Loss of CD4+ T cell IL-6R expression during inflammation underlines a role for IL-6 trans signaling in the local maintenance of Th17 cells.
Authors: Jones GW, McLoughlin RM, Hammond VJ, Parker CR, Williams JD, Malhotra R, Scheller J, Williams AS, Rose-John S, Topley N, Jones SA
J. Immunol., 2010;184(4):2130-9.
Species: Human
Sample Type: Whole Cells
Application: Flow
Phenotypic and functional markers for 1alpha,25-dihydroxyvitamin D(3)-modified regulatory dendritic cells.
Authors: Pedersen AW, Holmstrom K, Jensen SS, Fuchs D, Rasmussen S, Kvistborg P, Claesson MH, Zocca MB
Clin. Exp. Immunol., 2010;157(1):48-59.
Species: Human
Sample Type: Whole Cells
Application: Flow
CCR2 identifies a stable population of human effector memory CD4+ T cells equipped for rapid recall response.
Authors: Zhang HH, Song K, Rabin RL, Hill BJ, Perfetto SP, Roederer M, Douek DC, Siegel RM, Farber JM
J. Immunol., 2010;185(11):6646-63.
Species: Human
Sample Type: Whole Cells
Application: Flow
CCL21 overexpressed on lymphatic vessels drives thymic hyperplasia in myasthenia.
Authors: Berrih-Aknin S, Ruhlmann N, Bismuth J, Cizeron-Clairac G, Zelman E, Shachar I, Dartevelle P, de Rosbo NK, Le Panse R
Ann. Neurol., 2009;66(4):521-31.
Species: Human
Sample Type: Whole Cells
Application: Flow
Changes in chemokines and chemokine receptor expression on tonsillar B cells upon Epstein-Barr virus infection.
Authors: Ehlin-Henriksson B, Liang W, Cagigi A, Mowafi F, Klein G, Nilsson A
Immunology, 2009;127(4):549-57.
Species: Human
Sample Type: Whole Cells
Application: Flow
Expression of soluble vascular endothelial growth factor receptor-1 in human monocyte-derived mature dendritic cells contributes to their antiangiogenic property.
Authors: Kishuku M, Nishioka Y, Abe S, Kishi J, Ogino H, Aono Y, Azuma M, Kinoshita K, Batmunkh R, Rentsenhand B, Makino H, Ranjan P, Minakuchi K, Sone S
J. Immunol., 2009;183(12):8176-85.
Species: Human
Sample Type: Whole Cells
Application: Flow
An unusual CD56(bright) CD16(low) NK cell subset dominates the early posttransplant period following HLA-matched hematopoietic stem cell transplantation.
Authors: Dulphy N, Haas P, Busson M, Belhadj S, Peffault de Latour R, Robin M, Carmagnat M, Loiseau P, Tamouza R, Scieux C, Rabian C, Di Santo JP, Charron D, Janin A, Socie G, Toubert A
J. Immunol., 2008;181(3):2227-37.
Species: Human
Sample Type: Whole Cells
Application: Flow
Alpha1beta1 integrin is crucial for accumulation of epidermal T cells and the development of psoriasis.
Authors: Conrad C, Boyman O, Tonel G, Tun-Kyi A, Laggner U, de Fougerolles A, Kotelianski V, Gardner H, Nestle FO
Nat. Med., 2007;13(7):836-42.
Species: Human
Sample Type: Whole Cells
Application: Flow
Intravenous immunoglobulins suppress T-cell priming by modulating the bidirectional interaction between dendritic cells and natural killer cells.
Authors: Tha-In T, Metselaar HJ, Tilanus HW, Groothuismink ZM, Kuipers EJ, De Man RA, Kwekkeboom J
Blood, 2007;110(9):3253-62.
Species: Human
Sample Type: Whole Cells
Application: Flow
Potential role for IL-7 in Fas-mediated T cell apoptosis during HIV infection.
Authors: Fluur C, De Milito A, Fry TJ, Vivar N, Eidsmo L, Atlas A, Federici C, Matarrese P, Logozzi M, Rajnavolgyi E, Mackall CL, Fais S, Chiodi F, Rethi B
J. Immunol., 2007;178(8):5340-50.
Species: Human
Sample Type: Whole Cells
Application: Flow
Aberration of CCR7 CD8 memory T cells from patients with systemic lupus erythematosus: an inducer of T helper type 2 bias of CD4 T cells.
Authors: Sen Y, Chunsong H, Baojun H, Linjie Z, Qun L, San J, Qiuping Z, Junyan L, Zhang X, Jinquan T
Immunology, 2004;112(2):274-89.
Species: Human
Sample Type: Whole Cells
Application: Flow
TCR affinity associated with functional differences between dominant and subdominant SIV epitope-specific CD8+ T cells in Mamu-A*01+ rhesus monkeys.
Authors: Osuna C, Gonzalez A, Chang H, Hung A, Ehlinger E, Anasti K, Alam S, Letvin N
PLoS Pathog, 0;10(4):e1004069.
Species: Human
Sample Type: cells
Application: Flow

纯化方式Protein A or G purified from hybridoma culture supernatant
免疫原Human CCR7 transfectants
Met1-Pro378
Accession # AAA58615
生物活性Human
标记Fluorescein
背景

CCR7 is a 7 transmembrane G protein coupled chemokine receptor. CCR7 is expressed on T cells and mature dendritic cells and transduces chemotactic signals in response to CCL19 and CCL21. Human CCR7 shares 87% amino acid sequence identity with mouse CCR7.

运输条件Blue Ice
存放说明4℃
参考文献
  • Cancer Biomarkers
  • CC Chemokines and Receptors
  • Chemokine Receptors
  • Chemokines and Receptors in Angiogenesis
  • Chemokines and Receptors in Tfh Cell Differentiation and Function
  • Dendritic Cell Adhesion and Migration
  • Human CD Marker Products
  • ICC / IHC Images: CCR7
  • Regulatory T Cells (Tregs)
  • T Cell Migration/Adhesion
  • Technical Notes: CCR7
参考图片
Detection of CCR7 in Human Blood Lymphocytes by Flow Cytometry. Human peripheral blood lymphocytes were stained with Mouse Anti-Human CD4 APC‑conjugated Monoclonal Antibody (Catalog # FAB3791A) and either (A) Mouse Anti-Human CCR7 Fluorescein‑conjugated Monoclonal Antibody (Catalog # FAB197F) or (B) Mouse IgG2A Fluorescein Isotype Control (Catalog # IC003F). View our protocol for Staining Membrane-associated Proteins.
Detection of CCR7 in HEK293 Human Cell Line Transfected with Human CCR7 and eGFP by Flow Cytometry. The specificity of Mouse Anti-Human CCR7 Clone 150503 was demonstrated by its ability to react with (A) HEK293 human embryonic kidney cell line transfected with human CCR7 and not react with (B) irrelevant HEK293 transfectants. Antibody binding was monitored using Phycoerythrin-conjugated Anti-Mouse IgG Secondary Antibody (Catalog # F0102B).