Hu Wnt16 Pure W/Cont F4-1582 50ug
货号：
552595 基本售价：
12095.0 元 规格：
50ug
产品信息
概述| 货号 | 552595 |
| 描述 | The Wnt gene family comprises a large group of signaling proteins involved in developmental pathways in vertebrates, Drosophilia, C. elegans and other organisms. The Wnt genes were first discovered in mouse (called int-1 ) and later in Drosophilia(calledwingless , or wg) where the signaling pathways were unravelled. The Wnt proteins are involved in various developmental processes including embryonic induction, generation of cell polarity and the specification of cell fate. The vertebrate Wnt glycoproteins number at least 16 members and initiate signaling by being secreted and a subset of these glycoproteins bind to a class of receptors, called Frizzled, of which 11 have been identified. Stimulation of the Wnt pathway causes the phosphorylation of Dishevelled, which inhibits glycogen synthase kinase -3 β(GSK3β ) and allows β -catenin to accumulate in the cytosol. β -catenin then translocates to the nucleus to form a complex with Tcf/LEF family of transcription factors to activate transcription. In unstimulated cells, β -catenin forms a complex with the proteins Axin, adenomatous polyposis coli (APC), (GSK3ß) and is unstable. Studies have shown that some members of this pathway become mutated in human cancers, such as colon carcinoma and melanoma. Futhermore, studies on the WNT-16 gene, have shown that it is activated by the E2A-Pbx fusion product in acute lymphoblastoid leukemia. Wnt16 has a predicted molecular weight of 40 kDa (SWISS-PROT:Q9UBV4). |
| 同种亚型 | IgG2b |
| 反应种属 | Human (QC Testing) |
| 来源宿主 | Mouse |
| 使用方法 | WB |
性能| 供应商 | BD Pharmingen |
| 免疫原 | Human WNT16 Recombinant Protein |
| 存放说明 | The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
Store the undiluted antibody at 4°C. Store 697 cell lysate at -20°C. |
| 浓度 | 0.5 mg/ml |
