Hu CD126 Biotin M182 500ug
货号：
552503 基本售价：
11880.0 元 规格：
500ug
产品信息
概述| 货号 | 552503 |
| 描述 | The M182 antibody reacts with the a subunit of the human IL-6 Receptor (IL-6R α , aka, CD126). The human IL-6R α is an 80 kDa type I transmembrane glycoprotein, also known as B cell stimulatory factor-2 (BSF-2) receptor and IL-6 receptor. The IL-6R α subunit associates with the 130-160 kDa gp130 subunit (IL-6 receptor ß chain, CD130), that is shared with the receptors for Leukemia Inhibitory Factor (LIF), Ciliary Neurotropic Factor (CNTF), Oncostatin M (OSM), IL-11, Cardiotropin 1 (CT-1) and possibly Neurotrophin-1/B Cell-Stimulating Factor 3 (NNT-1/BSF-3). The IL-6R α chain binds IL-6 with low affinity, however the association with CD130 stabilizes the IL-6/IL-6R α complex resulting in the formation of a high affinity complex. The IL-6R ß chain mediates signal transduction. IL-6R α s are expressed at high levels by activated and EBV-transformed B cells, plasma cells and myeloma cells and at lower levels by most leucocytes, epithelial cells, fibroblasts, hepatocytes and neural cells. IL-6R α exists in soluble form in human serum. The serum levels of soluble IL-6Raappear to elevate in pathological situations such as multiple myeloma, Graves disease, juvenile chronic arthritis and HIV.10-13 The immunogen used to generate the M182 hybridoma was a mixture of U266, XG-1 (human myeloma cell line expressing membrane IL-6R) and BWD41 cells (murine thymoma cell line transfected with cDNA encoding the extracellular part of IL-6R α). |
| 别名 | IL-6 Receptor α Chain |
| 同种亚型 | IgG1,κ |
| 反应种属 | Human (QC Testing) |
| 来源宿主 | Mouse |
| 使用方法 | ELISA Det. |
性能| 供应商 | BD Pharmingen |
| 免疫原 | Mixture of U266, XG-1and BWD41 cells |
| 标记 | Biotin |
| 存放说明 | The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.The antibody was conjugated with biotin under optimum conditions, and unreacted biotin was removed.Store undiluted at 4°C.
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| 存储溶液 | Aqueous buffered solution containing ≤0.09% sodium azide. |
| 浓度 | 0.5 mg/ml |
