Hu CD358 (DR6) A647 DR-6-04-EC 50Tst
货号：
566343 基本售价：
9805.0 元 规格：
50Tst
产品信息
概述| 货号 | 566343 |
| 描述 | The DR-6-04-EC monoclonal antibody specifically binds to CD358 which is also known as Death Receptor 6 (DR6). CD358 is a single-pass type I transmembrane glycoprotein that is encoded by TNFRSF21 (Tumor necrosis factor receptor superfamily member 21). CD358 is comprised of four TNFR-cysteine rich repeats in its extracellular domain and has a cytoplasmic death domain. CD358 is expressed by cells in a variety of tissues including the nervous system, heart, placenta, pancreas, thymus, lymph nodes, and bone marrow. CD358 can also be highly expressed by a large variety of tumor cells and cancer cell lines. CD358 is capable of apoptotic signaling or activation of JNK or NF- κ B signaling pathways upon ligand binding and functions in regulating cellular proliferation, differentiation, or survival. In the immune system, CD358 was found to be highly expressed by plasmacytoid dendritic cells (pDCs) and may play an important role in type-I interferon (IFN-I) production. CD358 reportedly helps regulate T cell and B cell proliferation and differentiation. A cleaved, soluble form of the full CD358 extracellular domain has been described that appears to have immunomodulatory functions. |
| 别名 | TNFR-related death receptor 6; DR6; BM-018; TNFRSF21; TNR21 |
| 同种亚型 | Mouse IgG1 |
| 反应种属 | Human (QC Testing) |
性能| 供应商 | BD Pharmingen |
| 免疫原 | Human DR6 Recombinant Protein |
| 存放说明 | Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.The antibody was conjugated to Alexa Fluor® 647 under optimum conditions, and unreacted Alexa Fluor® 647 was removed.
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| 存储溶液 | Aqueous buffered solution containing BSA and ≤0.09% sodium azide. |
