Hu CD255 (TWEAK) PE CARL-1 100Tst
货号：
552831 基本售价：
9075.0 元 规格：
100Tst
产品信息
概述| 货号 | 552831 |
| 描述 | The CARL-1 monoclonal antibody specifically binds to CD255, also known as TWEAK (TNF-related WEAK inducer of apoptosis). The CD255 cytokine belongs to the tumor necrosis factor (TNF) ligand family and is encoded by the TNFSF12(Tumor necrosis factor ligand superfamily member 12 ) gene. CD255 (TWEAK) is present as a type II transmembrane protein form and a smaller, biologically-active secreted isoform. CD255 is expressed on most tissues and non-lymphoid tumor cell lines but has weak or no expression on hematopoietic lineage cell lines. CD255 is not detectable on resting peripheral blood mononuclear cells. However, its expression is upregulated on peripheral blood monocytes in response to IFN- γ stimulation. CD255 can act through the TWEAK Receptor (aka, TWEAK-R, TNFRSF12A, Fn14, and CD266) to induce a variety of target cellular responses including NF-kB activation, proliferation, apoptosis, IL-8 and GM-CSF production. Clone CARL-2, a different monoclonal antibody, also binds to TWEAK although it binds to a different TWEAK epitope. |
| 别名 | CD255; TWEAK; TNFSF12; APO3 ligand; APO3L; DR3LG |
| 同种亚型 | IgG3 |
| 反应种属 | Human (QC Testing) |
| 来源宿主 | Mouse |
| 使用方法 | FC |
性能| 供应商 | BD Pharmingen |
| 免疫原 | Human Tweak Transfected Cell Line |
| 标记 | PE |
| 存放说明 | Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.The antibody was conjugated with R-PE under optimum conditions, and unconjugated antibody and free PE were removed.
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| 存储溶液 | Aqueous buffered solution containing BSA, protein stabilizer, and ≤0.09% sodium azide. |
