Hu Soluble CD14 Biotin 3-C39 500ug
货号：
551405 基本售价：
9045.0 元 规格：
500ug
产品信息
概述| 货号 | 551405 |
| 描述 | The 3-C39 monoclonal antibody reacts with human CD14. CD14 is a 53-55kDa cell surface glycoprotein that is expressed by mature monocytes, macrophages, and activated granulocytes as a glycophosphatidylinositol-linked protein. CD14 functions as a receptor for lipopolysaccharide (LPS, endotoxin) when LPS is bound to LBP (LPS binding protein). Soluble forms of CD14 (sCD14) can be detected either in serum or in supernatants from cell cultures. Soluble CD14 is produced either by shedding of membrane CD14 or by release from cells before addition of the GPI anchor. Both membrane and sCD14 function to enhance cell activation by LPS. Binding of LPS-LBP complexes to CD14 activates monocytes or macrophages to produce and secrete cytokines and pro-inflammatory mediators. Non-CD14 expressing cells, such as endothelial cells, can be activated by a complex of LPS and sCD14. Serum levels of sCD14 increase in association with sepsis, infectious disease, autoimmunity and allergic disorders. |
| 别名 | sCD14 |
| 同种亚型 | IgG2a,κ |
| 反应种属 | Human (QC Testing) |
| 来源宿主 | Mouse |
| 使用方法 | ELISA Det. |
性能| 供应商 | BD Pharmingen |
| 免疫原 | Soluble Human CD14 |
| 标记 | Biotin |
| 存放说明 | Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.The antibody was conjugated with biotin under optimum conditions, and unreacted biotin was removed.
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| 存储溶液 | Aqueous buffered solution containing protein stabilizer and ≤0.09% sodium azide. |
| 浓度 | 0.5 mg/ml |
